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http://dx.doi.org/10.14348/molcells.2016.2330

Distribution and Features of the Six Classes of Peroxiredoxins  

Poole, Leslie B. (Department of Biochemistry, Wake Forest School of Medicine)
Nelson, Kimberly J. (Department of Biochemistry, Wake Forest School of Medicine)
Publication Information
Molecules and Cells / v.39, no.1, 2016 , pp. 53-59 More about this Journal
Abstract
Peroxiredoxins are cysteine-dependent peroxide reductases that group into 6 different, structurally discernable classes. In 2011, our research team reported the application of a bioinformatic approach called active site profiling to extract active site-proximal sequence segments from the 29 distinct, structurally-characterized peroxiredoxins available at the time. These extracted sequences were then used to create unique profiles for the six groups which were subsequently used to search GenBank(nr), allowing identification of ~3500 peroxiredoxin sequences and their respective subgroups. Summarized in this minireview are the features and phylogenetic distributions of each of these peroxiredoxin subgroups; an example is also provided illustrating the use of the web accessible, searchable database known as PREX to identify subfamily-specific peroxiredoxin sequences for the organism Vitis vinifera (grape).
Keywords
active site profiling; bioinformatics; disulfide reductase; peroxide reductase; thiol peroxidase;
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