[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.14348/molcells.2016.2368

Overview on Peroxiredoxin

Rhee, Sue Goo (Yonsei Biomedical Research Institute, Yonsei University College of Medicine)

Abstract

Peroxiredoxins (Prxs) are a very large and highly conserved family of peroxidases that reduce peroxides, with a conserved cysteine residue, designated the "peroxidatic" Cys ( $C_P$ ) serving as the site of oxidation by peroxides (Hall et al., 2011; Rhee et al., 2012). Peroxides oxidize the $C_P$ -SH to cysteine sulfenic acid ( $C_P$ -SOH), which then reacts with another cysteine residue, named the "resolving" Cys ( $C_R$ ) to form a disulfide that is subsequently reduced by an appropriate electron donor to complete a catalytic cycle. This overview summarizes the status of studies on Prxs and relates the following 10 minireviews.

Keywords

circadian rhythm; hydrogen peroxide; peroxiredoxin; redox regulation; thiol-specific peroxidasee;

Citations & Related Records

Times Cited By KSCI : 10 (Citation Analysis)

Reference
Cited By KSCI

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4	(2020) Antioxidants Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells / 9 (4) , 320
10	(2020) FEBS letters Crystal structure of <I>Akkermansia muciniphila</I> peroxiredoxin reveals a novel regulatory mechanism of typical 2‐Cys Prxs by a distinct loop / 594 (10) , 1550
6	(2020) Antioxidants Redox Conformation-Specific Protein–Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis / 9 (6) , 515
None	(2016) Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Whey protein boosts the antioxidant profile of rats by enhancing the activities of crucial antioxidant enzymes in a tissue-specific manner / 142 (None) , 111508
3	(2020) Molecular medicine reports Peroxiredoxin I deficiency increases pancreatic β-cell apoptosis after streptozotocin stimulation via the AKT/GSK3β signaling pathway / 22 (3) , 1831
7	(2016) Molecular biology reports The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it? / 47 (7) , 5587
2	(2020) Vestnik transplantologii i iskusstvennyh organov Use of peroxiredoxin for preconditioning of heterotopic heart transplantation in a rat / 22 (2) , 158
8	(2020) Antioxidants Enzymatic Antioxidant Signatures in Hyperthermophilic Archaea / 9 (8) , 703
9	(2020) Experimental & molecular medicine : EMM Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm / 52 (9) , 1587
77	(2016) Chemical communications : Chem comm Exploration and quantification of ascorbate affecting peroxidase-catalyzed chromogenic reactions with a recirculating-flow catalysis detection system / 56 (77) , 11481
None	(2016) Scientific reports Protein signatures of seminal plasma from bulls with contrasting frozen-thawed sperm viability / 10 (None) , 14661
1	(2020) Scientific reports Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice / 10 (1) , 17934
12	(2016) Genes Unlocking Survival Mechanisms for Metal and Oxidative Stress in the Extremely Acidophilic, Halotolerant <I>Acidihalobacter</I> Genus / 11 (12) , 1392
12	(2016) Antioxidants Oxidative Stress and Antioxidant Treatments in Cardiovascular Diseases / 9 (12) , 1292
None	(2016) Cancer management and research Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma / 13 (None) , 5725
None	(2016) Contact : CTC Post-Translational Modification of Cysteines: A Key Determinant of Endoplasmic Reticulum-Mitochondria Contacts (MERCs) / 4 (None) , 251525642110012
1	(2016) Journal of enzyme inhibition and medicinal chemistry Thioredoxin-dependent system. Application of inhibitors / 36 (1) , 362
None	(2016) Oxidative medicine and cellular longevity Antioxidative Stress: Inhibiting Reactive Oxygen Species Production as a Cause of Radioresistance and Chemoresistance / 2021 (None) , 1
None	(2021) PeerJ <I>De novo</I> assembly and functional annotation of blood transcriptome of loggerhead turtle, and <I>in silico</I> characterization of peroxiredoxins and thioredoxins / 9 (None) , e12395
None	(2016) Evidence-based Complementary and Alternative Medicine : eCAM Sex-Biased Gene Expression of Mesobuthus martensii Collected from Gansu Province, China, Reveals Their Different Therapeutic Potentials / 2021 (None) , 1
None	(2016) Frontiers in cellular neuroscience Emerging Evidence Highlighting the Importance of Redox Dysregulation in the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS) / 14 (None) , 581950
4	(2016) International journal of molecular sciences Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer’s Disease / 22 (4) , 1687
2	(2016) Current neuropharmacology The Dawn of Mitophagy: What Do We Know by Now? / 19 (2) , 170
2	(2016) Antioxidants Tyrosine Phosphorylation Modulates Peroxiredoxin-2 Activity in Normal and Diseased Red Cells / 10 (2) , 206
2	(2016) Antioxidants Fighting Bisphenol A-Induced Male Infertility: The Power of Antioxidants / 10 (2) , 289
5	(2016) Applied sciences Physical Activity and Redox Balance in the Elderly: Signal Transduction Mechanisms / 11 (5) , 2228
3	(2016) Antioxidants Stoichiometric Thiol Redox Proteomics for Quantifying Cellular Responses to Perturbations / 10 (3) , 499
8	(2021) International journal of molecular sciences The Role of Non-Coding RNAs in the Neuroprotective Effects of Glutathione / 22 (8) , 4245
5	(2016) Human & experimental toxicology Induction of apoptosis in indole-3-carbinol-treated lung cancer H1299 cells via ROS level elevation / 40 (5) , 812
6	(2016) Antioxidants Peroxiredoxins—The Underrated Actors during Virus-Induced Oxidative Stress / 10 (6) , 977
7	(2016) Antioxidants β-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes / 10 (7) , 1153
8	(2016) Genome biology and evolution Rapid Genomic Evolution Drives the Diversification of Male Reproductive Genes in Dung Beetles / 13 (8) , evab172
8	(2016) Journal of fungi H2O2 Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in Aspergillus nidulans / 7 (8) , 624
16	(2016) Journal of experimental botany Photosynthesis and chloroplast redox signaling in the age of global warming: stress tolerance, acclimation, and developmental plasticity / 72 (16) , 5919
None	(2021) Journal of proteomics Label-free proteomic analysis reveals differentially expressed Wolbachia proteins in Tyrophagus putrescentiae: Mite allergens and markers reflecting population-related proteome differences / 249 (None) , 104356
1	(2016) Nature communications Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation / 12 (1) , 6626
1	(2016) Genes and environment : the official journal of the Japanese Environmental Mutagen Society PRDX1 is essential for the viability and maintenance of reactive oxygen species in chicken DT40 / 43 (1) , 35
12	(2016) Life The Role of the CREB Protein Family Members and the Related Transcription Factors in Radioresistance Mechanisms / 11 (12) , 1437
1	(2022) Antioxidants Adaptative Up-Regulation of PRX2 and PRX5 Expression Characterizes Brain from a Mouse Model of Chorea-Acanthocytosis / 11 (1) , 76