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http://dx.doi.org/10.14348/molcells.2015.0131

Tricyclic Antidepressants Amitriptyline and Desipramine Induced Neurotoxicity Associated with Parkinson's Disease  

Lee, Min-yeong (Department of Molecular Biology, Sejong University)
Hong, Seokheon (Department of Molecular Biology, Sejong University)
Kim, Nahmhee (Department of Biology, Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)
Shin, Ki Soon (Department of Biology, Department of Life and Nanopharmaceutical Sciences, Kyung Hee University)
Kang, Shin Jung (Department of Molecular Biology, Sejong University)
Publication Information
Molecules and Cells / v.38, no.8, 2015 , pp. 734-740 More about this Journal
Abstract
Recent studies report that a history of antidepressant use is strongly correlated with the occurrence of Parkinson' disease (PD). However, it remains unclear whether antidepressant use can be a causative factor for PD. In the present study, we examined whether tricyclic antidepressants amitriptyline and desipramine can induce dopaminergic cell damage, both in vitro and in vivo. We found that amitriptyline and desipramine induced mitochondria-mediated neurotoxicity and oxidative stress in SH-SY5Y cells. When injected into mice on a subchronic schedule, amitriptyline induced movement deficits in the pole test, which is known to detect nigrostriatal dysfunction. In addition, the number of tyrosine hydroxylase-positive neurons in the substantia nigra pars compacta was reduced in amitriptyline-injected mice. Our results suggest that amitriptyline and desipramine may induce PD-associated neurotoxicity.
Keywords
amitriptyline; desipramine; neurotoxicity; Parkinson' disease; tricyclic antidepressant;
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