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http://dx.doi.org/10.14348/molcells.2015.0124

pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans  

Cho, Injeong (Department of Biology Education, College of Education, Chosun University)
Hwang, Gyu Jin (Department of Biology Education, College of Education, Chosun University)
Cho, Jeong Hoon (Department of Biology Education, College of Education, Chosun University)
Publication Information
Molecules and Cells / v.38, no.8, 2015 , pp. 729-733 More about this Journal
Abstract
C. elegans has two functional peroxidasins (PXN), PXN-1 and PXN-2. PXN-2 is essential to consolidate the extracellular matrix during development and is suggested to interact with PXN-1 antagonistically. pxn-1 is involved in neuronal development and possibly maintenance; therefore, we investigated the relationship between pxn-1 and pxn-2 in neuronal development and in aging. During neuronal development, defects caused by pxn-1 overexpression were suppressed by overexpression of both pxn-1 and pxn-2. In neuronal aging process, pxn-1 mutants showed less age-related neuronal defects, such as neuronal outgrowth, neuronal wavy processes, and enhanced short-term memory performance. In addition, pxn-2 overexpressing animals retained an intact neuronal morphology when compared with age-matched controls. Consistent with these results, overexpression of both pxn-1 and pxn-2 restored the severe neuronal defects present with pxn-1 overexpression. These results implied that there is a negative relationship between pxn-1 and pxn-2 via pxn-1 regulating pxn-2. Therefore, pxn-1 may function in neuronal development and age-related neuronal maintenance through pxn-2.
Keywords
antagonistic relationship; C. elegans; neuronal aging; neuronal development; pxn-1; pxn-2;
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