1 |
Long, D.T., Joukov, V., Budzowska, M., and Walter, J.C. (2014). BRCA1 promotes unloading of the CMG helicase from a stalled DNA replication fork. Mol. Cell 56, 174-185.
DOI
ScienceOn
|
2 |
Mateos-Gomez, P.A., Gong, F., Nair, N., Miller, K.M., Lazzerini-Denchi, E., and Sfeir, A. (2015). Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination. Nature 518, 254-257.
DOI
ScienceOn
|
3 |
Meetei, A.R., de Winter, J.P., Medhurst, A.L., Wallisch, M., Waisfisz, Q., van de Vrugt, H.J., Oostra, A.B., Yan, Z., Ling, C., Bishop, C.E., et al. (2003). A novel ubiquitin ligase is deficient in Fanconi anemia. Nat. Genet. 35, 165-170.
DOI
ScienceOn
|
4 |
Meetei, A.R., Medhurst, A.L., Ling, C., Xue, Y., Singh, T.R., Bier, P., Steltenpool, J., Stone, S., Dokal, I., Mathew, C.G., et al. (2005). A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat. Genet. 37, 958-963.
DOI
ScienceOn
|
5 |
Mistry, H., Hsieh, G., Buhrlage, S.J., Huang, M., Park, E., Cuny, G.D., Galinsky, I., Stone, R.M., Gray, N.S., D'Andrea, A.D., et al. (2013). Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol. Cancer Ther. 12, 2651-2662.
DOI
ScienceOn
|
6 |
Moynahan, M.E., Pierce, A.J., and Jasin, M. (2001). BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell 7, 263-272.
DOI
ScienceOn
|
7 |
Negrini, S., Gorgoulis, V.G., and Halazonetis, T.D. (2010). Genomic instability--an evolving hallmark of cancer. Nat. Rev. Mol. Cell Biol. 11, 220-228.
DOI
ScienceOn
|
8 |
Niedzwiedz, W., Mosedale, G., Johnson, M., Ong, C.Y., Pace, P., and Patel, K.J. (2004). The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol. Cell 15, 607-620.
DOI
ScienceOn
|
9 |
Nijman, S.M., Huang, T.T., Dirac, A.M., Brummelkamp, T.R., Kerkhoven, R.M., D'Andrea, A.D., and Bernards, R. (2005). The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol. Cell 17, 331-339.
DOI
ScienceOn
|
10 |
Polito, D., Cukras, S., Wang, X., Spence, P., Moreau, L., D'Andrea, A.D., and Kee, Y. (2014). The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway. J. Biol. Chem. 289, 7003-7010.
DOI
ScienceOn
|
11 |
Psakhye, I., and Jentsch, S. (2012). Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair. Cell 151, 807-820.
DOI
ScienceOn
|
12 |
Rajendra, E., Oestergaard, V.H., Langevin, F., Wang, M., Dornan, G.L., Patel, K.J., and Passmore, L.A. (2014). The genetic and biochemical basis of FANCD2 monoubiquitination. Mol. Cell 54, 858-869.
DOI
ScienceOn
|
13 |
Raschle, M., Knipscheer, P., Enoiu, M., Angelov, T., Sun, J., Griffith, J.D., Ellenberger, T.E., Scharer, O.D., and Walter, J.C. (2008). Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 134, 969-980.
DOI
ScienceOn
|
14 |
Raschle, M., Smeenk, G., Hansen, R.K., Temu, T., Oka, Y., Hein, M.Y., Nagaraj, N., Long, D.T., Walter, J.C., Hofmann, K., et al. (2015). DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links. Science 348, 1253671.
DOI
ScienceOn
|
15 |
Sawyer, S.L., Tian, L., Kahkonen, M., Schwartzentruber, J., Kircher, M., University of Washington Centre for Mendelian, G., Consortium, F.C., Majewski, J., Dyment, D.A., Innes, A.M., et al. (2015). Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype. Cancer Discov. 5, 135-142.
DOI
ScienceOn
|
16 |
Schwab, R.A., Blackford, A.N., and Niedzwiedz, W. (2010). ATR activation and replication fork restart are defective in FANCMdeficient cells. EMBO J. 29, 806-818.
DOI
ScienceOn
|
17 |
Smogorzewska, A., Desetty, R., Saito, T.T., Schlabach, M., Lach, F.P., Sowa, M.E., Clark, A.B., Kunkel, T.A., Harper, J.W., Colaiacovo, M.P., et al. (2010). A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol. Cell 39, 36-47.
DOI
ScienceOn
|
18 |
Singh, T.R., Saro, D., Ali, A.M., Zheng, X.F., Du, C.H., Killen, M.W., Sachpatzidis, A., Wahengbam, K., Pierce, A.J., Xiong, Y., et al. (2010). MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Mol. Cell 37, 879-886.
DOI
ScienceOn
|
19 |
Singh, T.R., Ali, A.M., Paramasivam, M., Pradhan, A., Wahengbam, K., Seidman, M.M., and Meetei, A.R. (2013). ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions. Cancer Res. 73, 4300-4310.
DOI
ScienceOn
|
20 |
Smogorzewska, A., Matsuoka, S., Vinciguerra, P., McDonald, E.R., 3rd, Hurov, K.E., Luo, J., Ballif, B.A., Gygi, S.P., Hofmann, K., D'Andrea, A.D., et al. (2007). Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell 129, 289-301.
DOI
ScienceOn
|
21 |
Tian, Y., Paramasivam, M., Ghosal, G., Chen, D., Shen, X., Huang, Y., Akhter, S., Legerski, R., Chen, J., Seidman, M.M., et al. (2015). UHRF1 Contributes to DNA Damage Repair as a Lesion Recognition Factor and Nuclease Scaffold. Cell Rep. 10, 1957-1966.
DOI
ScienceOn
|
22 |
Unno, J., Itaya, A., Taoka, M., Sato, K., Tomida, J., Sakai, W., Sugasawa, K., Ishiai, M., Ikura, T., Isobe, T., et al. (2014). FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair. Cell Rep. 7, 1039-1047.
DOI
ScienceOn
|
23 |
Vaz, F., Hanenberg, H., Schuster, B., Barker, K., Wiek, C., Erven, V., Neveling, K., Endt, D., Kesterton, I., Autore, F., et al. (2010). Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat. Genet. 42, 406-409.
DOI
ScienceOn
|
24 |
Wang, A.T., Sengerova, B., Cattell, E., Inagawa, T., Hartley, J.M., Kiakos, K., Burgess-Brown, N.A., Swift, L.P., Enzlin, J.H., Schofield, C.J., et al. (2011). Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes Dev. 25, 1859-1870.
DOI
ScienceOn
|
25 |
Walden, H., and Deans, A.J. (2014). The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder. Ann. Rev. Biophys. 43, 257-278.
DOI
ScienceOn
|
26 |
Wang, X., Kennedy, R.D., Ray, K., Stuckert, P., Ellenberger, T., and D'Andrea, A.D. (2007). Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. Mol. Cell. Biol. 27, 3098-3108.
DOI
ScienceOn
|
27 |
Wang, H., Zhang, S.Y., Wang, S., Lu, J., Wu, W., Weng, L., Chen, D., Zhang, Y., Lu, Z., Yang, J., et al. (2009). REV3L confers chemoresistance to cisplatin in human gliomas: the potential of its RNAi for synergistic therapy. Neuro Oncol. 11, 790-802.
DOI
|
28 |
Williams, S.A., Longerich, S., Sung, P., Vaziri, C., and Kupfer, G.M. (2011a). The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI. Blood 117, 5078-5087.
DOI
ScienceOn
|
29 |
Williams, S.A., Maecker, H.L., French, D.M., Liu, J., Gregg, A., Silverstein, L.B., Cao, T.C., Carano, R.A., and Dixit, V.M. (2011b). USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma. Cell 146, 918-930.
DOI
ScienceOn
|
30 |
Williams, S.A., Wilson, J.B., Clark, A.P., Mitson-Salazar, A., Tomashevski, A., Ananth, S., Glazer, P.M., Semmes, O.J., Bale, A.E., Jones, N.J., et al. (2011c). Functional and physical interaction between the mismatch repair and FA-BRCA pathways. Hum. Mol. Genet. 20, 4395-4410.
DOI
ScienceOn
|
31 |
Xie, J., Kim, H., Moreau, L.A., Puhalla, S., Garber, J., Al Abo, M., Takeda, S., and D'Andrea, A.D. (2015). RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway. J. Clin. Invest. 125, 1523-1532.
DOI
ScienceOn
|
32 |
Wojtaszek, J., Lee, C.J., D'Souza, S., Minesinger, B., Kim, H., D'Andrea, A.D., Walker, G.C., and Zhou, P. (2012). Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) zeta, and Pol kappa. J. Biol. Chem. 287, 33836-33846.
DOI
|
33 |
Xia, B., Sheng, Q., Nakanishi, K., Ohashi, A., Wu, J., Christ, N., Liu, X., Jasin, M., Couch, F.J., and Livingston, D.M. (2006). Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol. Cell 22, 719-729.
DOI
ScienceOn
|
34 |
Xie, K., Doles, J., Hemann, M.T., and Walker, G.C. (2010). Errorprone translesion synthesis mediates acquired chemoresistance. Proc. Natl. Acad. Sci. USA 107, 20792-20797.
DOI
ScienceOn
|
35 |
Yamamoto, K.N., Kobayashi, S., Tsuda, M., Kurumizaka, H., Takata, M., Kono, K., Jiricny, J., Takeda, S., and Hirota, K. (2011). Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc. Natl. Acad. Sci. USA 108, 6492-6496.
DOI
ScienceOn
|
36 |
Yan, Z., Delannoy, M., Ling, C., Daee, D., Osman, F., Muniandy, P.A., Shen, X., Oostra, A.B., Du, H., Steltenpool, J., et al. (2010). A histone-fold complex and FANCM form a conserved DNAremodeling complex to maintain genome stability. Mol. Cell 37, 865-878.
DOI
ScienceOn
|
37 |
Yang, K., Moldovan, G.L., Vinciguerra, P., Murai, J., Takeda, S., and D'Andrea, A.D. (2011). Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev. 25, 1847-1858.
DOI
ScienceOn
|
38 |
Zhang, J., Dewar, J.M., Budzowska, M., Motnenko, A., Cohn, M.A., and Walter, J.C. (2015). DNA interstrand cross-link repair requires replication-fork convergence. Nat. Struct. Mol. Biol. 22, 242-247.
DOI
ScienceOn
|
39 |
Yarde, D.N., Oliveira, V., Mathews, L., Wang, X., Villagra, A., Boulware, D., Shain, K.H., Hazlehurst, L.A., Alsina, M., Chen, D.T., et al. (2009). Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma. Cancer Res. 69, 9367-9375.
DOI
ScienceOn
|
40 |
Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B., and Yu, X. (2009). PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr. Biol. 19, 524-529.
|
41 |
Zhou, W., Otto, E.A., Cluckey, A., Airik, R., Hurd, T.W., Chaki, M., Diaz, K., Lach, F.P., Bennett, G.R., Gee, H.Y., et al. (2012). FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. Nat. Genet. 44, 910-915.
DOI
ScienceOn
|
42 |
Bryant, H.E., Schultz, N., Thomas, H.D., Parker, K.M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N.J., and Helleday, T. (2005). Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913-917.
DOI
ScienceOn
|
43 |
Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.V., Kolettas, E., Niforou, K., Zoumpourlis, V.C., et al. (2006). Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444, 633-637.
DOI
ScienceOn
|
44 |
Blackford, A.N., Schwab, R.A., Nieminuszczy, J., Deans, A.J., West, S.C., and Niedzwiedz, W. (2012). The DNA translocase activity of FANCM protects stalled replication forks. Human molecular genetics 21, 2005-2016.
DOI
ScienceOn
|
45 |
Bogliolo, M., Schuster, B., Stoepker, C., Derkunt, B., Su, Y., Raams, A., Trujillo, J.P., Minguillon, J., Ramirez, M.J., Pujol, R., et al. (2013). Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia. American journal of human genetics 92, 800-806.
DOI
ScienceOn
|
46 |
Chang, D.J., and Cimprich, K.A. (2009). DNA damage tolerance:when it's OK to make mistakes. Nat. Chem. Biol. 5, 82-90.
DOI
ScienceOn
|
47 |
Budzowska, M., Graham, T.G., Sobeck, A., Waga, S., and Walter, J.C. (2015). Regulation of the Rev1-pol zeta complex during bypass of a DNA interstrand cross-link. EMBO J. pii: e201490878. [Epub ahead of print]
|
48 |
Bunting, S.F., Callen, E., Kozak, M.L., Kim, J.M., Wong, N., Lopez-Contreras, A.J., Ludwig, T., Baer, R., Faryabi, R.B., Malhowski, A., et al. (2012). BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. Mol. Cell 46, 125-135.
DOI
ScienceOn
|
49 |
Ceccaldi, R., Liu, J.C., Amunugama, R., Hajdu, I., Primack, B., Petalcorin, M.I., O'Connor, K.W., Konstantinopoulos, P.A., Elledge, S.J., Boulton, S.J., et al. (2015). Homologousrecombination-deficient tumours are dependent on Polthetamediated repair. Nature 518, 258-262.
DOI
ScienceOn
|
50 |
Chen, C.C., Kennedy, R.D., Sidi, S., Look, A.T., and D'Andrea, A. (2009). CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol. Cancer 8, 24.
DOI
ScienceOn
|
51 |
Chen, X.B., Melchionna, R., Denis, C.M., Gaillard, P.H., Blasina, A., Van de Weyer, I., Boddy, M.N., Russell, P., Vialard, J., and McGowan, C.H. (2001). Human Mus81-associated endonuclease cleaves Holliday junctions in vitro. Mol. Cell 8, 1117-1127.
DOI
ScienceOn
|
52 |
Chen, J., Dexheimer, T.S., Ai, Y., Liang, Q., Villamil, M.A., Inglese, J., Maloney, D.J., Jadhav, A., Simeonov, A., and Zhuang, Z. (2011). Selective and cell-active inhibitors of the USP1/UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chem. Biol. 18, 1390-1400.
DOI
ScienceOn
|
53 |
Collins, N.B., Wilson, J.B., Bush, T., Thomashevski, A., Roberts, K.J., Jones, N.J., and Kupfer, G.M. (2009). ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function. Blood 113, 2181-2190.
DOI
ScienceOn
|
54 |
Chirnomas, D., Taniguchi, T., de la Vega, M., Vaidya, A.P., Vasserman, M., Hartman, A.R., Kennedy, R., Foster, R., Mahoney, J., Seiden, M.V., et al. (2006). Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. Mol. Cancer Ther. 5, 952-961.
DOI
ScienceOn
|
55 |
Clauson, C., Scharer, O.D., and Niedernhofer, L. (2013). Advances in understanding the complex mechanisms of DNA interstrand cross-link repair. Cold Spring Harbor Perspect. Biol. 5, a012732.
|
56 |
Cohn, M.A., Kowal, P., Yang, K., Haas, W., Huang, T.T., Gygi, S.P., and D'Andrea, A.D. (2007). A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol. Cell 28, 786-797.
DOI
ScienceOn
|
57 |
Collis, S.J., Ciccia, A., Deans, A.J., Horejsi, Z., Martin, J.S., Maslen, S.L., Skehel, J.M., Elledge, S.J., West, S.C., and Boulton, S.J. (2008). FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol. Cell 32, 313-324.
DOI
ScienceOn
|
58 |
Cybulski, K.E., and Howlett, N.G. (2011). FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair. Cell Cycle 10, 1757-1763.
DOI
|
59 |
D'Andrea, A.D. (2010). Susceptibility pathways in Fanconi's anemia and breast cancer. N Engl. J. Med. 362, 1909-1919.
DOI
ScienceOn
|
60 |
Deans, A.J., and West, S.C. (2009). FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia. Mol. Cell 36, 943-953.
DOI
ScienceOn
|
61 |
Deans, A.J., and West, S.C. (2011). DNA interstrand crosslink repair and cancer. Nat. Rev. Cancer 11, 467-480.
DOI
ScienceOn
|
62 |
Gaillard, H., Garcia-Muse, T., and Aguilera, A. (2015). Replication stress and cancer. Nat. Rev. Cancer 15, 276-289.
DOI
ScienceOn
|
63 |
Di Micco, R., Fumagalli, M., Cicalese, A., Piccinin, S., Gasparini, P., Luise, C., Schurra, C., Garre, M., Nuciforo, P.G., Bensimon, A., et al. (2006). Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444, 638-642.
DOI
ScienceOn
|
64 |
Doles, J., Oliver, T.G., Cameron, E.R., Hsu, G., Jacks, T., Walker, G.C., and Hemann, M.T. (2010). Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy. Proc. Natl. Acad. Sci. USA 107, 20786-20791.
DOI
ScienceOn
|
65 |
Farmer, H., McCabe, N., Lord, C.J., Tutt, A.N., Johnson, D.A., Richardson, T.B., Santarosa, M., Dillon, K.J., Hickson, I., Knights, C., et al. (2005). Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917-921.
DOI
ScienceOn
|
66 |
Garaycoechea, J.I., and Patel, K.J. (2014). Why does the bone marrow fail in Fanconi anemia? Blood 123, 26-34.
DOI
ScienceOn
|
67 |
Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M.S., Timmers, C., Hejna, J., Grompe, M., and D'Andrea, A.D. (2001). Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol. Cell 7, 249-262.
DOI
ScienceOn
|
68 |
Gari, K., Decaillet, C., Delannoy, M., Wu, L., and Constantinou, A. (2008). Remodeling of DNA replication structures by the branch point translocase FANCM. Proc. Natl. Acad. Sci. USA 105, 16107-16112.
DOI
ScienceOn
|
69 |
Gibbs-Seymour, I., Oka, Y., Rajendra, E., Weinert, B.T., Passmore, L.A., Patel, K.J., Olsen, J.V., Choudhary, C., Bekker-Jensen, S., and Mailand, N. (2015). Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage. Mol. Cell 57, 150-164.
DOI
ScienceOn
|
70 |
Guainazzi, A., and Scharer, O.D. (2010). Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy. Cell Mol Life Sci. 67, 3683-3697.
DOI
|
71 |
Guervilly, J.H., Takedachi, A., Naim, V., Scaglione, S., Chawhan, C., Lovera, Y., Despras, E., Kuraoka, I., Kannouche, P., Rosselli, F., et al. (2015). The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability. Mol. Cell 57, 123-137.
DOI
ScienceOn
|
72 |
Hira, A., Yoshida, K., Sato, K., Okuno, Y., Shiraishi, Y., Chiba, K., Tanaka, H., Miyano, S., Shimamoto, A., Tahara, H., et al. (2015). Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi Anemia. Am. J. Hum. Genet. 96, 1001-1007.
DOI
ScienceOn
|
73 |
Ho, G.P., Margossian, S., Taniguchi, T., and D'Andrea, A.D. (2006). Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol. Cell. Biol. 26, 7005-7015.
DOI
ScienceOn
|
74 |
Hodskinson, M.R., Silhan, J., Crossan, G.P., Garaycoechea, J.I., Mukherjee, S., Johnson, C.M., Scharer, O.D., and Patel, K.J. (2014). Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair. Mol. Cell 54, 472-484.
DOI
ScienceOn
|
75 |
Huang, M., Kim, J.M., Shiotani, B., Yang, K., Zou, L., and D'Andrea, A.D. (2010). The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Mol. Cell 39, 259-268.
DOI
ScienceOn
|
76 |
Huang, M., Kennedy, R., Ali, A.M., Moreau, L.A., Meetei, A.R., D'Andrea, A.D., and Chen, C.C. (2011). Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway. DNA Repair 10, 1203-1212.
DOI
ScienceOn
|
77 |
Johnson, N., Li, Y.C., Walton, Z.E., Cheng, K.A., Li, D., Rodig, S.J., Moreau, L.A., Unitt, C., Bronson, R.T., Thomas, H.D., et al. (2011). Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat. Med. 17, 875-882.
DOI
ScienceOn
|
78 |
Huang, Y., Leung, J.W., Lowery, M., Matsushita, N., Wang, Y., Shen, X., Huong, D., Takata, M., Chen, J., and Li, L. (2014). Modularized functions of the Fanconi anemia core complex. Cell Rep. 7, 1849-1857.
DOI
ScienceOn
|
79 |
Ishiai, M., Kitao, H., Smogorzewska, A., Tomida, J., Kinomura, A., Uchida, E., Saberi, A., Kinoshita, E., Kinoshita-Kikuta, E., Koike, T., et al. (2008). FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat. Struct. Mol. Biol. 15, 1138-1146.
DOI
ScienceOn
|
80 |
Jacquemont, C., and Taniguchi, T. (2007). Proteasome function is required for DNA damage response and fanconi anemia pathway activation. Cancer Res. 67, 7395-7405.
DOI
ScienceOn
|
81 |
Joo, W., Xu, G., Persky, N.S., Smogorzewska, A., Rudge, D.G., Buzovetsky, O., Elledge, S.J., and Pavletich, N.P. (2011). Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway. Science 333, 312-316.
DOI
ScienceOn
|
82 |
Kandoth, C., McLellan, M.D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J.F., Wyczalkowski, M.A., et al. (2013). Mutational landscape and significance across 12 major cancer types. Nature 502, 333-339.
DOI
ScienceOn
|
83 |
Kee, Y., Huang, M., Chang, S., Moreau, L.A., Park, E., Smith, P.G., and D'Andrea, A.D. (2012). Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents. Mol. Cancer Res. 10, 369-377.
DOI
|
84 |
Kim, H., and D'Andrea, A.D. (2012). Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev. 26, 1393-1408.
DOI
ScienceOn
|
85 |
Kennedy, R.D., Chen, C.C., Stuckert, P., Archila, E.M., De la Vega, M.A., Moreau, L.A., Shimamura, A., and D'Andrea, A.D. (2007). Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J. Clin. Invest. 117, 1440-1449.
DOI
ScienceOn
|
86 |
Kikuchi, S., Hara, K., Shimizu, T., Sato, M., and Hashimoto, H. (2012). Structural basis of recruitment of DNA polymerase zeta by interaction between REV1 and REV7 proteins. J. Biol. Chem. 287, 33847-33852.
DOI
|
87 |
Kim, Y. (2014). Nuclease delivery: versatile functions of SLX4/FANCP in genome maintenance. Mol. Cells 37, 569-574.
DOI
ScienceOn
|
88 |
Kim, J.M., Parmar, K., Huang, M., Weinstock, D.M., Ruit, C.A., Kutok, J.L., and D'Andrea, A.D. (2009). Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev. Cell 16, 314-320.
DOI
ScienceOn
|
89 |
Kim, H., Yang, K., Dejsuphong, D., and D'Andrea, A.D. (2012). Regulation of Rev1 by the Fanconi anemia core complex. Nat. Struct. Mol. Biol. 19, 164-170.
DOI
ScienceOn
|
90 |
Klein Douwel, D., Boonen, R.A., Long, D.T., Szypowska, A.A., Raschle, M., Walter, J.C., and Knipscheer, P. (2014). XPFERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4. Mol. Cell 54, 460-471.
DOI
ScienceOn
|
91 |
Knipscheer, P., Raschle, M., Smogorzewska, A., Enoiu, M., Ho, T.V., Scharer, O.D., Elledge, S.J., and Walter, J.C. (2009). The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science 326, 1698-1701.
DOI
ScienceOn
|
92 |
Lehmann, A.R., Niimi, A., Ogi, T., Brown, S., Sabbioneda, S., Wing, J.F., Kannouche, P.L., and Green, C.M. (2007). Translesion synthesis: Y-family polymerases and the polymerase switch. DNA Repair 6, 891-899.
DOI
ScienceOn
|
93 |
Kottemann, M.C., and Smogorzewska, A. (2013). Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature 493, 356-363.
DOI
ScienceOn
|
94 |
Landais, I., Sobeck, A., Stone, S., LaChapelle, A., and Hoatlin, M.E. (2009). A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway. Int. J. Cancer 124, 783-792.
DOI
ScienceOn
|
95 |
Langevin, F., Crossan, G.P., Rosado, I.V., Arends, M.J., and Patel, K.J. (2011). Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. Nature 475, 53-58.
DOI
ScienceOn
|
96 |
Leung, J.W., Wang, Y., Fong, K.W., Huen, M.S., Li, L., and Chen, J. (2012). Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc. Natl. Acad. Sci. USA 109, 4491-4496.
DOI
|
97 |
Liang, Q., Dexheimer, T.S., Zhang, P., Rosenthal, A.S., Villamil, M.A., You, C., Zhang, Q., Chen, J., Ott, C.A., Sun, H., et al. (2014). A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat. Chem. Biol. 10, 298-304.
DOI
ScienceOn
|
98 |
Liang, C.C., Zhan, B., Yoshikawa, Y., Haas, W., Gygi, S.P., and Cohn, M.A. (2015). UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway. Cell Rep. 10, 1947-1956.
DOI
ScienceOn
|
99 |
Liu, Y., Tarsounas, M., O'Regan, P., and West, S.C. (2007). Role of RAD51C and XRCC3 in genetic recombination and DNA repair. J. Biol. Chem. 282, 1973-1979.
DOI
ScienceOn
|