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http://dx.doi.org/10.14348/molcells.2015.0098

Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct  

Guo, Jing (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology)
He, Hongjuan (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology)
Liu, Qi (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology)
Zhang, Fengwei (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology)
Lv, Jie (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology)
Zeng, Tiebo (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology)
Gu, Ning (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology)
Wu, Qiong (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology)
Publication Information
Molecules and Cells / v.38, no.10, 2015 , pp. 859-865 More about this Journal
Abstract
Most imprinted genes are concerned with embryonic development, especially placental development. Here, we identified a placenta-specific imprinted gene Qpct. Our results show that Qpct is widely expressed during early embryonic development and can be detected in the telecephalon, midbrain, and rhombencephalon at E9.5-E11.5. Moreover, Qpct is strikingly expressed in the brain, lung and liver in E15.5. Expression signals for Qpct achieved a peak at E15.5 during placental development and were only detected in the labyrinth layer in E15.5 placenta. ChIP assay results suggest that the modification of histone H3K4me3 can result in maternal activating of Qpct.
Keywords
expression patterns; H3K4me3; imprinted gene; Qpct; placenta;
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