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http://dx.doi.org/10.14348/molcells.2015.0263

Structural Studies of G Protein-Coupled Receptors  

Zhang, Dandan (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences)
Zhao, Qiang (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences)
Wu, Beili (CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences)
Publication Information
Molecules and Cells / v.38, no.10, 2015 , pp. 836-842 More about this Journal
Abstract
G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular mechanisms of GPCR ligand recognition, activation and allosteric modulation, as well as structural basis of GPCR dimerization. In this review, we will discuss the structural features of GPCRs and structural insights of different aspects of GPCR biological functions.
Keywords
activation; allosteric modulation; GPCR; ligand recognition; structure;
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