Hypoxia Inducible Factor-1α Directly Regulates Nuclear Clusterin Transcription by Interacting with Hypoxia Response Elements in the Clusterin Promoter |
Park, Jeongsook
(Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University)
Park, So Yun (Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Shin, Eunkyung (Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Lee, Sun Hee (Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Kim, Yoon Sook (Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Lee, Dong Hoon (Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Roh, Gu Seob (Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Kim, Hyun Joon (Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Kang, Sang Soo (Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Cho, Gyeong Jae (Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Jeong, Bo-Young (Department of Food & Nutrition, College of Natural Sciences, Gyeongsang National University) Kim, Hwajin (Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Choi, Wan Sung (Department of Anatomy and Neurobiology, Institute of Health Science, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) |
1 | Trougakos, I.P., So, A., Jansen, B., Gleave, M.E., and Gonos, E.S. (2004). Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress. Cancer Res. 64, 1834-1842. DOI ScienceOn |
2 | Wiesener, M.S., Jurgensen, J.S., Rosenberger, C., Scholze, C.K., Horstrup, J.H., Warnecke, C., Mandriota, S., Bechmann, I., Frei, U.A., Pugh, C.W., et al. (2003). Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J. 17, 271-273. DOI |
3 | Wilson, M.R., and Easterbrook-Smith, S.B. (2000). Clusterin is a secreted mammalian chaperone. Trends Biochem. Sci. 25, 95-98. DOI ScienceOn |
4 | Yamaji, R., Fujita, K., Takahashi, S., Yoneda, H., Nagao, K., Masuda, W., Naito, M., Tsuruo, T., Miyatake, K., Inui, H., et al. (2003). Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of exchanger. Biochim. Biophys. Acta. 1593, 269-276. DOI ScienceOn |
5 | Chen, N., Chen, X., Huang, R., Zeng, H., Gong, J., Meng, W., Lu, Y., Zhao, F., Wang, L., and Zhou, Q. (2009). BCL-xL is a target gene regulated by hypoxia-inducible factor-1{alpha}. J. Biol. Chem. 284, 10004-10012. DOI ScienceOn |
6 | Andersen, C.L., Schepeler, T., Thorsen, K., Birkenkamp-Demtroder, K., Mansilla, F., Aaltonen, L.A., Laurberg, S., and Orntoft, T.F. (2007). Clusterin expression in normal mucosa and colorectal cancer. Mol. Cell. Proteomics 6, 1039-1048. DOI ScienceOn |
7 | Bettuzzi, S. (2009). Chapter 1: Introduction. Adv. Cancer Res. 104, 1-8. DOI ScienceOn |
8 | Bettuzzi, S., Scorcioni, F., Astancolle, S., Davalli, P., Scaltriti, M., and Corti, A. (2002). Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression. Oncogene 21, 4328-4334. DOI ScienceOn |
9 | Cochrane, D.R., Wang, Z., Muramaki, M., Gleave, M.E., and Nelson, C.C. (2007). Differential regulation of clusterin and its isoforms by androgens in prostate cells. J. Biol. Chem. 282, 2278-2287. DOI ScienceOn |
10 | de Silva, H.V., Harmony, J.A., Stuart, W.D., Gil, C.M., and Robbins, J. (1990). Apolipoprotein J: structure and tissue distribution. Biochemistry 29, 5380-5389. DOI ScienceOn |
11 | Holmquist-Mengelbier, L., Fredlund, E., Lofstedt, T., Noguera, R., Navarro, S., Nilsson, H., Pietras, A., Vallon-Christersson, J., Borg, A., Gradin, K., et al. (2006). Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell 10, 413-423. DOI ScienceOn |
12 | Forsythe, J.A., Jiang, B.H., Iyer, N.V., Agani, F., Leung, S.W., Koos, R.D., and Semenza, G.L. (1996). Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16, 4604-4613. DOI |
13 | Kase, S., He, S., Sonoda, S., Kitamura, M., Spee, C., Wawrousek, E., Ryan, S.J., Kannan, R., and Hinton, D.R. (2010). alphaBcrystallin regulation of angiogenesis by modulation of VEGF. Blood 115, 3398-3406. DOI ScienceOn |
14 | Gleave, M., and Miyake, H. (2005). Use of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer. World J. Urol. 23, 38-46. DOI ScienceOn |
15 | Kevans, D., Gorman, S., Tosetto, M., Sheahan, K., O'Donoghue, D., Mulcahy, H., and O'Sullivan, J. (2012). Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer. J. Gastrointest. Cancer 43, 305-313. DOI ScienceOn |
16 | Kim, N., and Choi, W.S. (2011). Proapoptotic role of nuclear clusterin in brain. Anat. Cell Biol. 44, 169-175. DOI ScienceOn |
17 | Kim, N., Yoo, J.C., Han, J.Y., Hwang, E.M., Kim, Y.S., Jeong, E.Y., Sun, C.H., Yi, G.S., Roh, G.S., Kim, H.J., et al. (2011). Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. J. Cell Physiol. 227, 1157-1167. |
18 | Lee, D.H., Ha, J.H., Kim, Y., Bae, K.H., Park, J.Y., Choi, W.S., Yoon, H.S., Park, S.G., Park, B.C., Yi, G.S., et al. (2011). Interaction of a putative BH3 domain of clusterin with anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy. Biochem. Biophys. Res. Commun. 408, 541-547. DOI ScienceOn |
19 | Liao, F.T., Lee, Y.J., Ko, J.L., Tsai, C.C., Tseng, C.J., and Sheu, G.T. (2009). Hepatitis delta virus epigenetically enhances clusterin expression via histone acetylation in human hepatocellular carcinoma cells. J. Gen. Virol. 90, 1124-1134. DOI ScienceOn |
20 | Kim, N., Han, J.Y., Roh, G.S., Kim, H.J., Kang, S.S., Cho, G.J., Park, J.Y., and Choi, W.S. (2012). Nuclear clusterin is associated with neuronal apoptosis in the developing rat brain upon ethanol exposure. Alcohol Clin. Exp. Res. 36, 72-82. DOI ScienceOn |
21 | Leskov, K.S., Klokov, D.Y., Li, J., Kinsella, T.J., and Boothman, D.A. (2003). Synthesis and functional analyses of nuclear clusterin, a cell death protein. J. Biol. Chem. 278, 11590-11600. DOI ScienceOn |
22 | Loboda, A., Jozkowicz, A., and Dulak, J. (2010). HIF-1 and HIF-2 transcription factors--similar but not identical. Mol. Cells 29, 435-442. DOI ScienceOn |
23 | Millar, N.L., Reilly, J.H., Kerr, S.C., Campbell, A.L., Little, K.J., Leach, W.J., Rooney, B.P., Murrell, G.A., and McInnes, I.B. (2012). Hypoxia: a critical regulator of early human tendinopathy. Ann. Rheum. Dis. 71, 302-310. DOI |
24 | Nakamura, E., Abreu-e-Lima, P., Awakura, Y., Inoue, T., Kamoto, T., Ogawa, O., Kotani, H., Manabe, T., Zhang, G.J., Kondo, K., et al. (2006). Clusterin is a secreted marker for a hypoxiainducible factor-independent function of the von Hippel-Lindau tumor suppressor protein. Am. J. Pathol. 168, 574-584. DOI ScienceOn |
25 | Rauhala, H.E., Porkka, K.P., Saramaki, O.R., Tammela, T.L., and Visakorpi, T. (2008). Clusterin is epigenetically regulated in prostate cancer. Int. J. Cancer 123, 1601-1609. DOI ScienceOn |
26 | Poulios, E., Trougakos, I.P., and Gonos, E.S. (2006). Comparative effects of hypoxia on normal and immortalized human diploid fibroblasts. Anticancer Res. 26, 2165-2168. |
27 | Otrock, Z.K., Hatoum, H.A., Awada, A.H., Ishak, R.S., and Shamseddine, A.I. (2009). Hypoxia-inducible factor in cancer angiogenesis: structure, regulation and clinical perspectives. Crit. Rev. Oncol. Hematol. 70, 93-102. DOI ScienceOn |
28 | Piret, J.P., Mottet, D., Raes, M., and Michiels, C. (2002). , a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2. Ann. N Y Acad. Sci. 973, 443-447. DOI ScienceOn |
29 | Rizzi, F., and Bettuzzi, S. (2009). Clusterin (CLU) and prostate cancer. Adv. Cancer Res. 105, 1-19. DOI ScienceOn |
30 | Rizzi, F., and Bettuzzi, S. (2010). The clusterin paradigm in prostate and breast carcinogenesis. Endocr. Relat. Cancer 17, R1-17. DOI ScienceOn |
31 | Rizzi, F., Coletta, M., and Bettuzzi, S. (2009). Chapter 2: Clusterin (CLU): From one gene and two transcripts to many proteins. Adv. Cancer Res. 104, 9-23. DOI ScienceOn |
32 | Rosemblit, N., and Chen, C.L. (1994). Regulators for the rat clusterin gene: DNA methylation and cis-acting regulatory elements. J. Mol. Endocrinol. 13, 69-76. DOI ScienceOn |
33 | Schepeler, T., Mansilla, F., Christensen, L.L., Orntoft, T.F., and Andersen, C.L. (2007). Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling. J. Mol. Signal. 2, 6. DOI |
34 | Semenza, G.L. (1998). Hypoxia-inducible factor 1: master regulator of homeostasis. Curr. Opin. Genet. Dev. 8, 588-594. DOI ScienceOn |
35 | Rosenberg, M.E., and Silkensen, J. (1995). Clusterin: physiologic and pathophysiologic considerations. Int. J. Biochem. Cell Biol. 27, 633-645. DOI ScienceOn |
36 | Sala, A., Bettuzzi, S., Pucci, S., Chayka, O., Dews, M., and Thomas-Tikhonenko, A. (2009). Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis. Adv. Cancer Res. 105, 115-132. DOI ScienceOn |
37 | Salnikow, K., Donald, S.P., Bruick, R.K., Zhitkovich, A., Phang, J.M., and Kasprzak, K.S. (2004). Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J. Biol. Chem. 279, 40337-40344. DOI ScienceOn |
38 | Semenza, G.L. (2001). HIF-1, , and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107, 1-3. DOI ScienceOn |
39 | Serrano, A., Redondo, M., Tellez, T., Castro-Vega, I., Roldan, M.J., Mendez, R., Rueda, A., and Jimenez, E. (2009). Regulation of clusterin expression in human cancer via DNA methylation. Tumour. Biol. 30, 286-291. DOI ScienceOn |
40 | Shannan, B., Seifert, M., Leskov, K., Willis, J., Boothman, D., Tilgen, W., and Reichrath, J. (2006). Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer. Cell Death Differ. 13, 12-19. DOI ScienceOn |
41 | Trougakos, I.P., and Gonos, E.S. (2002). Clusterin/apolipoprotein J in human aging and cancer. Int. J. Biochem. Cell Biol. 34, 1430-1448. DOI ScienceOn |
42 | Lund, P., Weisshaupt, K., Mikeska, T., Jammas, D., Chen, X., Kuban, R.J., Ungethum, U., Krapfenbauer, U., Herzel, H.P., Schafer, R., et al. (2006). Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation. Oncogene 25, 4890-4903. DOI ScienceOn |
43 | Higashimura, Y., Nakajima, Y., Yamaji, R., Harada, N., Shibasaki, F., Nakano, Y., and Inui, H. (2011). Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Arch. Biochem. Biophys. 509, 1-8. DOI ScienceOn |
44 | Park, S.Y., Kim, J.B., and Han, Y.M. (2007). REST is a key regulator in brain-specific homeobox gene expression during neuronal differentiation. J. Neurochem. 103, 2565-2574. |
45 | Pucci, S., Bonanno, E., Pichiorri, F., Angeloni, C., and Spagnoli, L.G. (2004). Modulation of different clusterin isoforms in human colon tumorigenesis. Oncogene 23, 2298-2304. DOI ScienceOn |