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http://dx.doi.org/10.14348/molcells.2014.2245

ADP-Ribosylation: Activation, Recognition, and Removal  

Li, Nan (Department of Experimental Radiation Oncology, Unit 66, The University of Texas MD Anderson Cancer Center)
Chen, Junjie (Department of Experimental Radiation Oncology, Unit 66, The University of Texas MD Anderson Cancer Center)
Publication Information
Molecules and Cells / v.37, no.1, 2014 , pp. 9-16 More about this Journal
Abstract
ADP-ribosylation is a type of posttranslational modification catalyzed by members of the poly(ADP-ribose) (PAR) polymerase superfamily. ADP-ribosylation is initiated by PARPs, recognized by PAR binding proteins, and removed by PARG and other ADP-ribose hydrolases. These three groups of proteins work together to regulate the cellular and molecular response of PAR signaling, which is critical for a wide range of cellular and physiological functions.
Keywords
ADP-Ribosylation; PARG; PARP; PAR recognition domain;
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