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http://dx.doi.org/10.14348/molcells.2014.2206

Impaired Extinction of Learned Contextual Fear Memory in Early Growth Response 1 Knockout Mice  

Han, Seungrie (Department of Anatomy and Neuroscience, College of Medicine, Korea University)
Hong, Soontaek (Department of Anatomy and Neuroscience, College of Medicine, Korea University)
Mo, Jiwon (Department of Anatomy and Neuroscience, College of Medicine, Korea University)
Lee, Dongmin (Department of Anatomy and Neuroscience, College of Medicine, Korea University)
Choi, Eunju (Department of Psychology, Korea University)
Choi, June-Seek (Department of Psychology, Korea University)
Sun, Woong (Department of Anatomy and Neuroscience, College of Medicine, Korea University)
Lee, Hyun Woo (Department of Anatomy and Neuroscience, College of Medicine, Korea University)
Kim, Hyun (Department of Anatomy and Neuroscience, College of Medicine, Korea University)
Publication Information
Molecules and Cells / v.37, no.1, 2014 , pp. 24-30 More about this Journal
Abstract
Inductive expression of early growth response 1 (Egr-1) in neurons is associated with many forms of neuronal activity. However, only a few Egr-1 target genes are known in the brain. The results of this study demonstrate that Egr-1 knockout (KO) mice display impaired contextual extinction learning and normal fear acquisition relative to wild-type (WT) control animals. Genome-wide microarray experiments revealed 368 differentially expressed genes in the hippocampus of Egr-1 WT exposed to different phases of a fear conditioning paradigm compared to gene expression profiles in the hippocampus of KO mice. Some of genes, such as serotonin receptor 2C (Htr2c), neuropeptide B (Npb), neuronal PAS domain protein 4 (Npas4), NPY receptor Y1 (Npy1r), fatty acid binding protein 7 (Fabp7), and neuropeptide Y (Npy) are known to regulate processing of fearful memories, and promoter analyses demonstrated that several of these genes contained Egr-1 binding sites. This study provides a useful list of potential Egr-1 target genes which may be regulated during fear memory processing.
Keywords
contextual fear conditioning; Egr-1; extinction; hippocampus; microarray;
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