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http://dx.doi.org/10.1007/s10059-009-0148-2

Involvement of HIF-1α in UVB-Induced Epidermal Hyperplasia  

Cho, Young-Suk (Department of Pharmacology, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine)
Kim, Chan-Hyung (Department of Pharmacology, Chungbuk National University College of Medicine)
Park, Jong-Wan (Department of Pharmacology, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine)
Publication Information
Molecules and Cells / v.28, no.6, 2009 , pp. 537-543 More about this Journal
Abstract
Keratinocyte overgrowth after UVB exposure is believed to contribute to skin photoageing and cancer development. However, little is known about the transcription factors that epigenetically regulate keratinocyte response to UVB. Recently, $HIF-1{\alpha}$ was found to play a role in epidermal homeostasis by controlling the keratinocyte cell cycle, and thus, we hypothesized that $HIF-1{\alpha}$ is involved in UVB-induced keratinocyte growth. In cultured keratinocytes, $HIF-1{\alpha}$ was found to be down-regulated shortly after UVB exposure and to be involved in UVB-induced proliferation. In mice repeatedly treated with UVB, the epidermis became hyperplasic and keratinocytes lacked $HIF-1{\alpha}$ in nuclei. Based on these results, we suggest that the deregulation of $HIF-1{\alpha}$ is associated with UVB-induced hyperplasia of the epidermis. This work provides insight of the molecular mechanism underlying UV-induced photoageing and skin cancer development.
Keywords
hyperplasia; hypoxia-inducible factor-1alpha; keratinocyte; skin; ultraviolet;
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