The Effector Functions of Mature T Lymphocytes Are Impaired in Transgenic Mice Expressing the SH2 Domain of TSAd/Lad
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Choi, Youngbong
(Department of Life Science, Ewha Womans University)
Park, Eunkyung (Department of Life Science, Ewha Womans University) Ahn, Eunseon (Department of Life Science, Ewha Womans University) Park, Inyoung (Department of Life Science, Ewha Womans University) Yun, Yungdae (Department of Life Science, Ewha Womans University) |
1 | Ben-Horin, S., and Bank, I. (2004). The role of very late antigen-1 in immune-mediated inflammation. Clin. Immunol. 113, 119-129 DOI ScienceOn |
2 | Choi, Y.B., Kim, C.K., and Yun, Y. (1999). Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation. J. Immunol. 163, 5242-5249 PUBMED |
3 | Vandermoere, F., El Yazidi-Belkoura, I., Slomianny, C., Demont, Y., Bidaux, G., Adriaenssens, E., Lemoine, J., and Hondermarck, H. (2006). The valosin-containing protein (VCP) is a target of Akt signaling required for cell survival. J. Biol. Chem. 281, 14307-14313 DOI ScienceOn |
4 | Weninger, W., Crowley, M.A., Manjunath, N., and von Andrian, U.H. (2001). Migratory properties of naive, effector, and memory CD8(+) T cells. J. Exp. Med. 194, 953-966 DOI ScienceOn |
5 | Park, D., Park, I., Lee, D., Choi, Y.B., Lee, H., and Yun, Y. (2007). The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration. Blood 109, 5122-5128 DOI PUBMED ScienceOn |
6 | Marti, F., Post, N.H., Chan, E., and King, P.D. (2001). A transcription function for the T cell-specific adapter (TSAd) protein in T cells: critical role of the TSAd Src homology 2 domain. J. Exp. Med. 193, 1425-1430 DOI ScienceOn |
7 | Marti, F., and King, P.D. (2005). The p95-100 kDa ligand of the T cell-specific adaptor (TSAd) protein Src-homology-2 (SH2) domain implicated in TSAd nuclear import is p97 Valosincontaining protein (VCP). Immunol. Lett. 97, 235-243 DOI ScienceOn |
8 | Pribila, J.T., and Shimizu, Y. (2003). Signal transduction events regulating integrin function and T cell migration: new functions and complexity. Immunol. Res. 27, 107-128 DOI ScienceOn |
9 | Xu, H., DiIulio, N.A., and Fairchild, R.L. (1996). T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells. J. Exp. Med. 183, 1001-1012 DOI PUBMED ScienceOn |
10 | Madeo, F., Schlauer, J., Zischka, H., Mecke, D., and Frohlich, K.U. (1998). Tyrosine phosphorylation regulates cell cycle-dependent nuclear localization of Cdc48p. Mol. Biol. Cell 9, 131-141 DOI PUBMED |
11 | Shimizu, C., Kawamoto, H., Yamashita, M., Kimura, M., Kondou, E., Kaneko, Y., Okada, S., Tokuhisa, T., Yokoyama, M., Taniguchi, M.I et al. (2001). Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity. Int. Immunol. 13, 105-117 DOI ScienceOn |
12 | Grabbe, S., and Schwarz, T. (1998). Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol. Today 19, 37-44 DOI ScienceOn |
13 | Leo, A., and Schraven, B. (2001). Adapters in lymphocyte signalling. Curr. Opin. Immunol. 13, 307-316 DOI ScienceOn |
14 | Cavani, A., Albanesi, C., Traidl, C., Sebastiani, S., and Girolomoni, G. (2001). Effector and regulatory T cells in allergic contact dermatitis. Trends Immunol. 22, 118-120 DOI ScienceOn |
15 | Dai, R.M., and Li, C.C. (2001). Valosin-containing protein is a multiubiquitin chain-targeting factor required in ubiquitin-proteasome degradation. Nat. Cell Biol. 3, 740-744 DOI ScienceOn |
16 | Granum, S., Andersen, T. C., Sorlie, M., Jorgensen, M., Koll, L., Berge, T., Lea, T., Fleckenstein, B., Spurkland, A., and Sundvold- Gjerstad, V. (2008). Modulation of Lck function through multisite docking to T cell-specific adapter protein. J. Biol. Chem. 283, 21909-21919 DOI ScienceOn |
17 | Mustelin, T., and Tasken, K. (2003). Positive and negative regulation of T-cell activation through kinases and phosphatases. Biochem. J. 371, 15-27 DOI ScienceOn |
18 | Rajagopal, K., Sommers, C.L., Decker, D.C., Mitchell, E.O., Korthauer, U., Sperling, A.I., Kozak, C.A., Love, P.E., and Bluestone, J.A. (1999). RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. J. Exp. Med. 190, 1657-1668 DOI PUBMED |
19 | Burbach, B.J., Medeiros, R.B., Mueller, K.L., and Shimizu, Y. (2007). T-cell receptor signaling to integrins. Immunol. Rev. 218, 65-81 DOI PUBMED ScienceOn |
20 | Chaffin, K.E., Beals, C.R., Wilkie, T.M., Forbush, K.A., Simon, M.I., and Perlmutter, R.M. (1990). Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADPribosyltransferase. EMBO J. 9, 3821-3829 PUBMED |
21 | Marti, F., Garcia, G.G., Lapinski, P.E., MacGregor, J.N., and King, P.D. (2006). Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells. J. Exp. Med. 203, 281-287 DOI ScienceOn |
22 | Jang, M., Park, B.C., Kang, S., Lee do, H., Cho, S., Lee, S.C., Bae, K.H., and Park, S.G. (2008). Mining of caspase-7 substrates using a degradomic approach. Mol. Cells 26, 152-157 PUBMED |
23 | Kliche, S., Breitling, D., Togni, M., Pusch, R., Heuer, K., Wang, X., Freund, C., Kasirer-Friede, A., Menasche, G., Koretzky, G.A., et al. (2006). The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. Mol. Cell. Biol. 26, 7130-7144 DOI ScienceOn |
24 | Spurkland, A., Brinchmann, J.E., Markussen, G., Pedeutour, F., Munthe, E., Lea, T., Vartdal, F., and Aasheim, H.C. (1998). Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites. J. Biol. Chem. 273, 4539-4546 DOI ScienceOn |
25 | Lanzavecchia, A., and Sallusto, F. (2001). Antigen decoding by T lymphocytes: from synapses to fate determination. Nat. Immunol. 2, 487-492 DOI ScienceOn |
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