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http://dx.doi.org/10.1007/s10059-009-0056-5

Every Single Cell Clones from Cancer Cell Lines Growing Tumors In Vivo May Not Invalidate the Cancer Stem Cell Concept  

Li, Fengzhi (Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute)
Publication Information
Molecules and Cells / v.27, no.4, 2009 , pp. 491-492 More about this Journal
Abstract
We present the result of our research on the tumorigenic ability of single cell clones isolated from an aggressive murine breast cancer cell line in a matched allografting mouse model. Tumor formation is basically dependent on the cell numbers injected per location. We argue that in vivo tumor formation from single cell clones, isolated in vitro from cancer cell lines, may not provide conclusive evidence to disprove the cancer stem cell (CSC) theory without additional data.
Keywords
allografting; cancer cell line; cancer stem cell; single cell clone; tumorigenic;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 5  (Related Records In Web of Science)
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