Analysis of Phosphorylation of the BRI1/BAK1 Complex in Arabidopsis Reveals Amino Acid Residues Critical for Receptor Formation and Activation of BR Signaling
![]() |
Yun, Hye Sup
(Department of Life Science, Chung-Ang University)
Bae, Young Hee (Division of Biological Science, Sookmyung Women's University) Lee, Yun Ji (Division of Biological Science, Sookmyung Women's University) Chang, Soo Chul (University College, Yonsei University) Kim, Seong-Ki (Department of Life Science, Chung-Ang University) Li, Jianming (Department of Molecular, Cellular, and Developmental Biology, University of Michigan) Nam, Kyoung Hee (Division of Biological Science, Sookmyung Women's University) |
1 | Chinchilla, D., Zipfel, C., Robatzek, S., Kemmerling, B., Nurnberger, T., Jones, J.D.G., Felix, G., and Boller, T. (2007). A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defense. Nature 448, 497-500 DOI ScienceOn |
2 | Heese, A., Hann, D.R., Glimenez-Ibanez, S., Jones, A.M.E., He, K., Li, J., Schroeder, J.I., Peck, S.C., and Rathjen, J.P. (2007). The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants. Proc. Natl. Acad. Sci. USA 104, 12217-12222 DOI ScienceOn |
3 | Mora-Garcia, S., Vert, G., Yin, Y., Cano-Delgado, A., Cheong, H., and Chory, J. (2004). Nuclear protein phosphatase with Kelch-repeat domains modulates the response to brassinosteroids in Arabidopsis. Genes Dev. 18, 448-460 DOI ScienceOn |
4 | Noguchi, T., Fusioka, S., Choe, S., Takatsuto, S., Yoshida, S., Yuan, H., Feldmann, K.A., and Tax, F.E. (1999). Brassinoster-oid-insensitive dwarf mutants of Arabidopsis accumulates brass-inosteroids. Plant Physiol. 121, 743-752 DOI ScienceOn |
5 | Shiu, S.H., and Bleeker, A.B. (2001). Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases. Proc. Natl. Acad. Sci. USA 98, 10763-10768 DOI ScienceOn |
6 | Wang, X., Goshe, M.B., Soderblom, E.J., Phinney, B.S., Kuchar, J.A., Li, J., Asami, T., Yoshida, S., Huber, S.C., and Clouse, S.D. (2005a). Identification and functional analysis of in vitro phosphorylation sites of the Arabidopsis BRASSINOSTEROID-INSENSITIVE1 receptor kinase. Plant Cell 17, 1685-1703 DOI ScienceOn |
7 | Wang, X., and Chory, J. (2006). Brassinosteroids regualate dissociation of BKI1, a negative regulator of BRI1 signaling from a plasma membrane. Science 131, 1118-1122 |
8 | Karlova, R., Boeren, S., Russinova, E., Aker, J., Vervoort, J., and de Vries, S.C. (2006). The Arabidopsis SOMATIC EMBRYOGENE-SIS RECEPTOR-LIKE KINASE1 protein complex includes BRASSINOSTEROID-INSENSITIVE 1. Plant Cell 18, 626-638 DOI ScienceOn |
9 | Friedrichsen, D.M., Joazeiro, C.A., Li, J., Hunter, T., and Chory, J. (2003). Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. Plant Physiol. 123, 1247-1256 DOI ScienceOn |
10 | Shah, K., Vervoort, J., and de Vries, S.C. (2001). Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase1 activation loop in phosphorylation. J. Biol. Chem. 276, 41263-41269 DOI ScienceOn |
11 | Ulrich, A., and Schlessinger, J. (1990). Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203-212 DOI ScienceOn |
12 | Mitchell, J.W., Mandava, N.B., Worley, J.F., Plimmer, J.R., and Smith, M.V. (1970). Brassins: a new family of plant hormones from rape pollen. Nature 225, 1065-1066 DOI ScienceOn |
13 | Asami, T., Min, Y.K., Nagata, N., Yamaguchi, K., Takatsuto, S., Fujioka, S., Murofushi, N., Yamaguchi, I., and Yoshida, S. (2000). Characterization of brassinazole, a triazole-type brassinosteroid biosynthesis inhibitor. Plant Physiol. 123, 93-100 DOI ScienceOn |
14 | Clause, S.D., and Sasse, J.M. (1998). Brassinosteroids: Essential regulators of plant growth and development. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49, 427-451 DOI ScienceOn |
15 | Liu, Z.B., Ulmasov, T., Shi, X.Y., Hagen, G., and Guilfoyle, T.L. (1994). Soybean GH3 promoter contains multiple auxin-inducible elements. Plant Cell 6, 645-657 DOI PUBMED |
16 | Vert, G., Nemhauser, J.L., Geldner, N., Hong, F., and Chory, J. (2005). Molecular mechanisms of steroid hormone signaling in plants. Annu. Rev. Cell Dev. Biol. 21, 177-201 DOI ScienceOn |
17 | Burgess, A.W., Cho, H.S., Eigenbrot, C., Furguson, K.M., Gareet T.P., Leahy, D.J., Lemmon, M.A., Sliwkowski, M.X., Ward, C.W., Yokoyama, S. (2003). An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol. Cell 12, 541-552 DOI ScienceOn |
18 | Yamamuro, C., Ihara, Y., Wu, X., Noguchi, T., Fujoka, S., Takatsuto, S., Ashikari, M., Kitano, H., and Matsuoka, M. (2002). Loss of Function of a rice brassinosteroid insensitive1 homolog prevents internode elongation and bending of the lamina joint. Plant Cell 12, 1591-1606 |
19 | Yin, Y., Mora-Garcia, S., Li, J., Yoshida, S, Asami, T., and Chory, J. (2002). BES1 accumulates in the nucleus in response to brassinosteriods to regulate gene expression and promote stem elongation. Cell 109, 181-191 DOI ScienceOn |
20 | Nam, K.H., and Li, J. (2004). The Arabidopsis transthyretin-like protein is a potential substrate of BRASSINOSTEROID-INSENSITIVE 1. Plant Cell 16, 2406-2417 DOI ScienceOn |
21 | Wang, Z.Y., Nakano, T., Gendron, J., He, J.X., Chen, M., Vafedos, D., Yang, Y., Fujioka, S., Yoshida, S, Asami, T., et al. (2002). Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis. Dev. Cell 2, 505-515 DOI ScienceOn |
22 | Wang, X., Li, X., Meisenhelder, J., Hunter, T., Yoshida, S., Asami, T., and Chory, J. (2005b). Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1. Dev. Cell 8, 855-865 DOI ScienceOn |
23 | Li, J., and Nam, K.H. (2002). Regulation of brassinosteroid signaling by a GSK3/SHAGGY-like kinase. Science 295, 1299-1301 PUBMED |
24 | Pwason, T., and Nash, P. (2000). protein-protein interactions define specificity in signal transduction. Genes Dev. 14, 1027-1047 |
25 | Hecht, V., Vielle-Calzada, J., Hartog, M.V., Schmidt, E.D.L., Boutilier, K., Grossniklasu, U., and de Vries, S.C. (2001) The Arabidopsis SOMATIC EMBRYOGENESIS RECEPROE KINASE 1 gene is expressed in developing ovule and embryos and enhances embryogenic competence in culture. Plant Physiol. 127, 803-816 DOI ScienceOn |
26 | Nam, K.H., and Li, J. (2002). BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling. Cell 110, 203-212 DOI ScienceOn |
27 | Wang, Z.Y., Seto, H., Fujioka, S., Yoshida, S., and Chory, J. (2001). BRI1 is a critical component of a plasma-membrane receptor for plant steroids. Nature 410, 380-383 DOI ScienceOn |
28 | Ehsan, H., Ray, W.K., Phinney, B., Wang, X., Huber, S.C., Clause, S.D. (2005). Interaction of Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase with a homolog of mammalian TGF-beta receptor interacting protein. Plant J. 43, 251-261 DOI ScienceOn |
29 | Oh, M.H., Ray, W.K., Huber, S.C., Asara, J.M., Gage, D.A., and Clause, S.D. (2000). Recombinant brassinosteroid insensitive 1 receptor-like kinase autophosphorylates on serine and threonine residues and phosphorylates a conserved peptode motif in vitro. Plant Physiol. 124, 751-766 DOI ScienceOn |
30 | Massague, J. (1998). TGF-beta signal transduction. Annu. Rev. Biochem. 67, 753-791 DOI PUBMED ScienceOn |
31 | Li, J., and Chory. M. (1997). A putative leucine-rich repeat receptor kinase involve in brassinosteroid signal transduction. Cell 90, 927-938 |
32 | Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254 DOI PUBMED ScienceOn |
33 | Goda, H., Shimada, Y., Asmami, T., Fujioka, S., and Yishida, S. (2002). Microarray analysis of brassinostroid-regulated genes in Arabidopsis. Plant Physiol. 130, 1319-1334 DOI ScienceOn |
34 | Nomura, T., Kitasaka, Y., Takatsuto, S., Reid, J.B., Fukami, M., and Yokoda, T. (1999). Brassinosteroid/sterol synthesis and plant growth as affected by lka and lkb mutations of peas. Plant Physiol. 119, 1517-1526 DOI ScienceOn |
35 | Chono M., Honda I., Zeniya H., Yoneyama K., Saisho D., Takeda K., Takatsuto S., Hoshino T., and Watanabe Y.(2003). A semidwarf phenotype of barley uzu results from a nucleotide substitution in the gene encoding a putative brassinosteroid receptor, Plant Physiol. 133, 1209-1219 DOI ScienceOn |
36 | He, Z., Gendron, J. M., Yang, Y., Li, J., and Wang, Z.Y. (2002). The GSK3-like kinase BIN2 phosphorylates abd destabilized BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis. Proc. Nat. Acad. Sci. USA 99, 10185-10190 DOI ScienceOn |
37 | TenDijke, P., and Hill, C.S. (2004). New insight into TGF-beta-Smad signaling. Trends Biochem. Sci. 29, 265-273 DOI ScienceOn |
38 | Zurek, D.M., Rayle, D.L., McMorris, T.C., and Clause, S.D. (1994). Investigation of gene-expression, growth-kinetics, and wall extensibility during brassinosteroid-regulated stem elongation. Plant Physiol. 104, 505-513 DOI |
39 | Goda, H., Sawa, S., Asami, T., Fujioka, S., Shimada, Y., Yoshida, S. (2004). Comprehensive comparison of auxin-regulated and brassinosteroid-regulated genes in Arabidopsis. Plant Physiol. 134, 1555-1573 DOI PUBMED ScienceOn |
40 | Kinoshita, T., Cano-Delgado, A., Seto, H., Hiranuma, S., Fujuika, S., and Chory, J. (2005). Binding of brassinosteroids to the extracellular domain of plant receptor kinase BRI1. Nature 433, 167-171 DOI ScienceOn |
41 | Li, J., Wen, J., Lease, K.A., Dorke, J.T., Tax, F.E., and Walker, J.C. (2002). BAK1, an Arabidopsis LRR receptor-like kinase, interacts with BRI1 and modulates brassinosteroid signaling. Cell 110, 213-222 DOI ScienceOn |
![]() |