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Gene Expression Profiling of the Rewarding Effect Caused by Methamphetamine in the Mesolimbic Dopamine System  

Yang, Moon Hee (Department of Biological Science, Sookmyung Women's University)
Jung, Min-Suk (Departments of Pharmacology and Neurology, Institute for Medical Sciences Chonbuk National University Medical School)
Lee, Min Joo (Department of Biological Science, Sookmyung Women's University)
Yoo, Kyung Hyun (Department of Biological Science, Sookmyung Women's University)
Yook, Yeon Joo (Department of Biological Science, Sookmyung Women's University)
Park, Eun Young (Department of Biological Science, Sookmyung Women's University)
Choi, Seo Hee (Department of Biological Science, Sookmyung Women's University)
Suh, Young Ju (Department of Biological Science, Sookmyung Women's University)
Kim, Kee-Won (Departments of Pharmacology and Neurology, Institute for Medical Sciences Chonbuk National University Medical School)
Park, Jong Hoon (Department of Biological Science, Sookmyung Women's University)
Publication Information
Molecules and Cells / v.26, no.2, 2008 , pp. 121-130 More about this Journal
Abstract
Methamphetamine, a commonly used addictive drug, is a powerful addictive stimulant that dramatically affects the CNS. Repeated METH administration leads to a rewarding effect in a state of addiction that includes sensitization, dependence, and other phenomena. It is well known that susceptibility to the development of addiction is influenced by sources of reinforcement, variable neuroadaptive mechanisms, and neurochemical changes that together lead to altered homeostasis of the brain reward system. These behavioral abnormalities reflect neuroadaptive changes in signal transduction function and cellular gene expression produced by repeated drug exposure. To provide a better understanding of addiction and the mechanism of the rewarding effect, it is important to identify related genes. In the present study, we performed gene expression profiling using microarray analysis in a reward effect animal model. We also investigated gene expression in four important regions of the brain, the nucleus accumbens, striatum, hippocampus, and cingulated cortex, and analyzed the data by two clustering methods. Genes related to signaling pathways including G-protein-coupled receptor-related pathways predominated among the identified genes. The genes identified in our study may contribute to the development of a gene modeling network for methamphetamine addiction.
Keywords
CPP; drug addiction; expression profiling; methamphetamine; microarray; pathway analysis;
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