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Human Vesicular Glutamate Transporters Functionally Complement EAT-4 in C. elegans  

Lee, Dukgyu (Department of Life Science, Gwangju Institute of Science and Technology)
Jung, Sunki (HCC R&D Center)
Ryu, Jungmin (HCC R&D Center)
Ahnn, Joohong (Department of Life Science, Gwangju Institute of Science and Technology)
Ha, Ilho (IBST/Graduate Program in Neuroscience, Inje University)
Publication Information
Molecules and Cells / v.25, no.1, 2008 , pp. 50-54 More about this Journal
Abstract
The vesicular glutamate transporter (VGLUT) transports glutamate into pre-synaptic vesicles. Three isoforms of VGLUT have been identified in humans, but their functional differences remain largely unknown. EAT-4 is the only homologue of human VGLUT in C. elegans. Here we report that mutants of eat-4 exhibit hyperforaging behavior and that each of the isoforms of human VGLUT functionally rescues the defects in eat-4 worms.
Keywords
C. elegans; eat-4; Foraging; Pharyngeal Pumping; VGLUT;
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