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Peroxisome Proliferator-activated Receptor-γ Gene Polymorphisms are not associated with Osteonecrosis of the Femoral Head in the Korean Population  

Kim, Tae-Ho (Skeletal Diseases Genome Research Center, Kyungpook National University Hospital)
Hong, Jung Min (Skeletal Diseases Genome Research Center, Kyungpook National University Hospital)
Park, Eui Kyun (Skeletal Diseases Genome Research Center, Kyungpook National University Hospital)
Kim, Shin-Yoon (Skeletal Diseases Genome Research Center, Kyungpook National University Hospital)
Publication Information
Molecules and Cells / v.24, no.3, 2007 , pp. 388-393 More about this Journal
Abstract
Osteonecrosis of the femoral head (ONFH) is a multifactorial disease to which certain individuals are more at risk. Altered lipid metabolism is one of the major risk factors for osteonecrosis, especially corticosteroid therapy and alcoholism. Peroxisome Proliferator-Activated Receptor-${\gamma}$ ($PPAR{\gamma}$) plays a crucial role in differentiation of mesenchymal cells to adipocytes, lipid homeostasis, and bone metabolism. To investigate the possible association between $PPAR{\gamma}$ gene variants and susceptibility to ONFH, we genotyped three common polymorphisms (-796A > G, +34C > G[Pro12Ala], and +82466C > T[His477His]) in 448 ONFH patients and 336 control subjects. Genotypes, allele frequencies, and haplotypes of the polymorphisms in the complete set of patients as well as in subgroups by sex or etiology were not significantly different from those in the control group. This suggests that the examined polymorphisms and haplotypes of the $PPAR{\gamma}$ gene are unlikely to be associated with susceptibility to ONFH.
Keywords
Adipogenesis; Femoral head; Osteonecrosis; Polymorphism; $PPAR{\gamma}$;
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