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Short-Term Cold Exposure May Cause a Local Decrease of Neuropeptide Y in the Rat Hypothalamus

Park, Joong Jean (Department of Physiology, College of Medicine, Korea University)
Lee, Heung Kyung (Department of Physiology, College of Medicine, Korea University)
Shin, Min Woo (Department of Physiology, College of Medicine, Korea University)
Kim, Sung Jin (Department of Physiology, College of Medicine, Korea University)
Noh, Seung Yeon (Department of Medical Sciences, College of Medicine, Korea University)
Shin, Jin (Department of Medical Sciences, College of Medicine, Korea University)
Yu, Woo Sung (Department of Medical Sciences, College of Medicine, Korea University)

Abstract

Neuropeptide Y (NPY) is an orexigenic and hypothermic peptide. To understand its role in hypothermic conditions, male rats were placed in a $24^{\circ}C$ or $4^{\circ}C$ air chamber for 1.5 h. The expression of c-Fos protein, and NPY mRNA and protein, was analyzed in the hypothalamus 1 h-2 h later. The cold treatment increased the number of c-Fos-immunoreactive cells in the paraventricular hypothalamic nucleus (PVN) and arcuate nucleus (ARC). At the same time it decreased the density of NPY-immunoreactive components in the PVN, dorsomedial hypothalamic nucleus and ARC, as well as of NPY transcripts in the PVN and ARC. No colocalization of c-Fos with NPY was detected. These results suggest that short-term cold exposure should reduce indirectly NPY production in some hypothalamic nuclei to facilitate thermogenesis without inducing feeding behavior.

Keywords

Arcuate Nucleus; c-Fos; Hypothalamus; Hypothermia; Neuropeptide Y;

Citations & Related Records

Times Cited By Web Of Science : 4 (Related Records In Web of Science)

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