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Formation of a New Solo-LTR of the Human Endogenous Retrovirus H Family in Human Chromosome 21  

Huh, Jae-Won (Division of Biological Sciences, College of Natural Sciences, Pusan National University)
Kim, Dae-Soo (PBBRC, Interdisciplinary Research Program of Bioinformatics, Pusan National University)
Ha, Hong-Seok (Division of Biological Sciences, College of Natural Sciences, Pusan National University)
Kim, Tae-Hong (Division of Biological Sciences, College of Natural Sciences, Pusan National University)
Kim, Wook (Department of Biological Sciences, Dankook University)
Kim, Heui-Soo (Division of Biological Sciences, College of Natural Sciences, Pusan National University)
Publication Information
Molecules and Cells / v.22, no.3, 2006 , pp. 360-363 More about this Journal
Abstract
Human endogenous retroviruses (HERVs) contribute to various kinds of genomic instability via rearrangement and retrotransposition events. In the present study the formation of a new human-specific solo-LTR belonging to the HERV-H family (AP001667; chromosome 21q21) was detected by a comparative analysis of human chromosome 21 and chimpanzee chromosome 22. The solo-LTR was formed as a result of an equal homologous recombination excision event. Several evolutionary processes have occurred at this locus during primate evolution, indicating that mammalian-wide interspersed repeat (MIR) and full-length HERV-H elements integrated into hominoid genomes after the divergence of Old World monkeys and hominoids, and that the solo-LTR element was created by recombination excision of the HERV-H only in the human genome.
Keywords
HERV-H Element; Solo-LTR; Recombination Excision; Retrotransposition;
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