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JNK Regulation of Oncogenesis  

Heasley, Lynn E. (Department of Medicine, University of Colorado Health Sciences Center)
Han, Sun-Young (School of Life Sciences and Biotechnology, Korea University)
Publication Information
Molecules and Cells / v.21, no.2, 2006 , pp. 167-173 More about this Journal
Abstract
The literature provides strong precedent for both pro-tumorigenic and tumor suppressor roles for the c-Jun N-terminal kinases (JNKs) in the setting of oncogenesis. Clearly, JNKs are activated by numerous oncogenes and growth factors and the literature documents a role for these MAP kinases in cell proliferation and transformation. By contrast, JNKs mediate signals from diverse stimuli that result in cell death or differentiation and a role for JNKs as tumor suppressors has emerged. This enigmatic nature of the JNKs in the setting of oncogenesis is considered herein. Further illumination of the complex and context-dependent functions of the JNKs in cancer cells is of obvious importance for the rational use of small molecule JNK inhibitors as therapeutics.
Keywords
JNK; MAP Kinase; Tumorigenesis; Transformation; Tumor Suppressor;
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