Effects of Ginsenosides and Their Metabolites on Voltage-dependent Ca2+ Channel Subtypes
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Lee, Jun-Ho
(Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University)
Jeong, Sang Min (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Kim, Jong-Hoon (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Lee, Byung-Hwan (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Yoon, In-Soo (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Lee, Joon-Hee (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Choi, Sun-Hye (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Lee, Sang-Mok (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) Park, Yong-Sun (Department of Chemistry, Konkuk University) Lee, Jung-Ha (Department of Life Science, Sogang University,) Kim, Sung Soo (Korea Food Research Institute) Kim, Hyoung-Chun (Neurotoxicology Program, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University) Lee, Boo-Yong (College of Medicine, Pochon CHA University) Nah, Seung-Yeol (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) |
1 | Choi, D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623−634 DOI ScienceOn |
2 |
Kim, J. H., Hong, Y. H., Lee, J. H., Kim, D. H., Jeong, S. M., et al. (2005a) A role for the carbohydrate portion of ginsenoside Rg3 in |
3 | Kudo, K., Tachikawa, E., Kashimoto, T., and Takahashi, E. (1998) Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells. Eur. J. Pharmacol. 341, 139−144 DOI |
4 |
Lee, J. H., Jeong, S. M., Kim, J. H., Lee, B. H., Yoon, I. S., et al. (2005) Characteristics of ginsenoside |
5 |
Miller, R. J. (2001) Rocking and rolling with |
6 | Mori, Y., Friedrich, T., Kim, M. S., Mikami, A., Nakai, J., et al. (1991) Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature 350, 398−402 DOI ScienceOn |
7 |
Schneider, T., Wei, X., Olcese, R., Costantin, J. L., Neely, A., et al. (1994) Molecular analysis and functional expression of the human type E neuronal |
8 |
Tachikawa, E., Kudo, T., Kashimoto, T., and Takashshi, E. (1995) Ginseng saponins reduce acetylcholine-evoked |
9 | Wakabayashi, C., Murakami, K., Hasegawa, H., Murata, J., and Saiki, I. (1998) An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem. Biophys. Res. Commun. 249, 725− 730 |
10 |
Wang, G., Dayanithi, G., Newcomb, R., and Lemos, J. R. (1999) An R-type |
11 | Dascal, N. (1987) The use of Xenopus oocytes for the study of ion channels. CRC Crit. Rev. Biochem. 22, 317−387 DOI |
12 | Kim, S., Ahn, K., Oh, T. H., Nah, S. Y., and Rhim, H. (2002) Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem. Biophys. Res. Commun. 296, 247-254 DOI ScienceOn |
13 |
Nooney, J. and Lodge, D. (1996) The use of invertebrate peptide toxins to establish |
14 | Berridge, M. J., Bootman, M. D., and Lipp, P. (1998) Calcium - a life and death signal. Nature 395, 645-668 DOI ScienceOn |
15 |
Choi, S., Jung, S. Y., Kim, C. H., Kim, H. S., Rhim, H., et al. (2001) Effect of ginsenosides on voltage-dependent |
16 | Murakami, M., Nakagawasai, O., Suzuki, T., Mobarakeh, I., Sakurada, Y., et al. (2004) Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice. Brain Res. 1024, 122−129 DOI |
17 | Bourinet, E., Soong, T. W., Stea, A., and Snutch, T. P. (1996) Determinants of the G protein-dependent opioid modulation of neuronal calcium channels. Proc. Natl. Acad. Sci. USA 93, 1486−1491 |
18 |
Choi, S., Lee, J. H., Oh, S., Rhim, H., Lee, S. M., et al. (2003) Effects of ginsenoside |
19 |
Kim, D., Park, D., Choi, S., Sun, M., Kim, C., et al. (2003) Thalamic control of visceral nociception mediated by T-type |
20 | Lee, J. H., Daud, A. N., Cribbs, L. L., Lacerda, A. E., Perevrzev, A., et al. (1999) Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J. Neurosci. 19, 1912-1921 |
21 |
Rhim, H., Kim, H., Lee, D. Y., Oh, T. H., and Nah, S. Y. (2002) Ginseng and ginsenoside |
22 | Jeong, S. M. and Nah, S. Y. (2005) Ginseng and ion channels: are ginsenosides, active components of Panax ginseng, differential modulator of ion channels. J. Ginseng Res. 29, 19−26 DOI |
23 | Lee, J. H., Kim, S. H., Kim D, Hong, H. N., and Nah, S. Y. (2001) Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainate-induced neurotoxicity in rat hippocampus. Neurosci. Lett. 325, 129-133 DOI ScienceOn |
24 | Takahashi, T. and Momiyama, A. (1993) Different types of calcium channels mediate central synaptic transmission. Nature 366, 156−158 DOI ScienceOn |
25 |
Jeong, S. M., Lee, J. H., Kim, J. H., Lee, B. H., Yoon, I. S., et al. (2004) Stereospecificity of ginsenoside |
26 |
Kim, H. S., Lee, J. H., Koo, Y. S., and Nah, S. Y. (1998) Effects of ginsenosides on |
27 | Pragnell, M., De Waard, M., Mori, Y., Tanabe, T., Snutch, T. P., et al. (1994) Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1- subunit. Nature 368, 67-70 DOI |
28 |
Nah, S. Y. and McCleskey, E. W. (1994) Ginseng root extract inhibits calcium channels in rat sensory neurons through a similar path, but different receptor, as |
29 | Hasegawa, H., Suzuki, R., Nagaoka, T., Tezuka, Y., Kadota, S., et al. (2002) Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol. Biol. Pharm. Bull. 25, 861-866 DOI ScienceOn |
30 | Kim, J. H., Kim, S., Yoon, I. S., Lee, J. H., Jang, B. J., et al. (2005b) Protective effects of ginseng saponins on 3-nitropropionic acid-induced striatal degeneration in rats. Neuropharmacology 48, 743−756 DOI ScienceOn |
31 | Choi, S., Jung, S. Y., Lee, J. H., Sala, F., Criado, M., et al. (2002a) Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur. J. Pharmacol. 442, 37−45 |
32 |
Watanabe, M., Sakuma, Y., and Kato, M. (2004) High expression of the R-type voltage-gated |
33 | Nah, S. Y. (1997) Ginseng, recent advances and trend. Korea J. Ginseng Sci. 21, 1−12 |
34 |
Nah, S. Y., Park, H. J., and McCleskey, E. W. (1995) A trace component of ginseng that inhibit |
35 | Guyot, M. C., Palfi, S., Stutzmann, J. M., Maziere, M., Hantraye, P., et al. (1997) Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats. Neuroscience 81, 141-149 DOI ScienceOn |
36 | Wakabayashi, C., Hasegawa, H., Murata, J., and Saiki, I. (1997) In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol. Res. 9, 411−417 |
37 | Choi, S., Jung, S. Y., Ko, Y. S., Koh, S. R., Rhim, H., et al. (2002b) Functional expression of a novel ginsenoside Rf binding protein from rat brain mRNA in Xenopus oocytes. Mol. Pharmacol. 61, 928−935 DOI ScienceOn |
38 |
Lee, B. H., Jeong, S. M., Lee, J. H., Kim, D. H., Kim, J. H., et al. (2004) Differential effect of ginsenoside metabolites on the 5- |
39 |
Sala, F., Mulet, J., Choi, S., Jung, S. Y., Nah, S. Y., et al. (2002) Effects of ginsenoside |
40 |
Liu, D., Li., B., Liu, Y., Attele, A. S., Kyle, J. W., et al. (2001) Voltage-dependent inhibition of brain |
41 |
Kim, D., Song, I., Keum, S., Lee, T., Jeong, M. J., et al. (2001) Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) Ttype |
42 |
Wheeler, D. B., Randall, A., and Tsien, R. (1994) Roles of Ntype and Q-type |
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