Attenuated Expression of Interferon-induced Protein Kinase PKR in a Simian Cell Devoid of Type I Interferons |
Park, Se-Hoon
(School of Life Sciences and Biotechnology, Korea University)
Choi, Jaydo (School of Life Sciences and Biotechnology, Korea University) Kang, Ju-Il (School of Life Sciences and Biotechnology, Korea University) Choi, Sang-Yun (School of Life Sciences and Biotechnology, Korea University) Hwang, Soon-Bong (Ilsong Institute of Life Science, Hallym University) Kim, Jungsuh P. (School of Life Sciences and Biotechnology, Korea University) Ahn, Byung-Yoon (Ilsong Institute of Life Science, Hallym University) |
1 | Baltzis, D., Li, S., and Koromilas, A. E. (2002) Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR. J. Biol. Chem. 277, 38364–38372 DOI ScienceOn |
2 | Diaz, M. O., Ziemin, S., Le Beau, M. M., Pitha, P., Smith, S. D., et al. (1988) Homologous deletion of the alpha- and beta 1 interferon genes in human leukemia and derived cell lines. Proc. Natl. Acad. Sci. USA 85, 5259–5263 |
3 | Frohman, M. A., Dush, M. K., and Martin, G. R. (1988) Rapid production of full-length cDNA from rare transcripts: Amplification using a single gene specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85, 8998–9002 |
4 | Mellor, H., Flowers, K. M., Kimball, S. R., and Jefferson, L. S. (1994) Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase. Biochim. Biophys. Acta 1219, 693-696 DOI ScienceOn |
5 | Samuel, C. E. (1979) Mechanism of interferon action: phosphorylation of protein synthesis initiation factor eIF-2 in interferon- treated human cells by a ribosome-associated protein kinase possessing site-specificity similar to heminregulated rabbit reticulocyte kinase. Proc. Natl. Acad. Sci. USA 76, 600–604 |
6 | Barber, G. N., Wambach, M., Thompson, S., Jagus, R., and Katze, M. G. (1995) Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation. Mol. Cell. Biol. 15, 3138-3146 |
7 | Koromilas, A. E., Roy, S., Barber, G. N., Katze, M. G., and Sonenberg, N. (1992) Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science 257, 1685-1689 DOI |
8 | Feng, G. S., Chong, K., Kumar, A., and Williams, B. R. G. (1992) Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNAactivated p68 kinase. Proc. Natl. Acad. Sci. USA 89, 5447– 5451 |
9 | Li, S. and Koromilas, A. E. (2001) Dominant negative function by an alternative spliced form of the interferon-inducible protein kinase PKR. J. Biol. Chem. 276, 13881-13890 |
10 | Tan, S. L. and Katze, M. G. (1999) The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death- J. Interferon Cytokine Res. 19, 543-554 DOI ScienceOn |
11 | Clemens, M. J. and Androulla, E. (1997) The double-stranded RNA-dependent protein kinase PKR: structure and function. J. Interferon Cytokine Res. 17, 503-524 DOI ScienceOn |
12 | Hershey, J. W. B. (1989) Protein phosphorylation controls translation rates. J. Biol. Chem. 264, 20823–20826 |
13 | Kumar, A., Haque, J., Lacoste, J., Hiscott, J., and Williams, B. R. (1994) Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. Proc. Natl. Acad. Sci. USA 91, 6288–6292 |
14 | Samuel, C. E. (1993) The eIF-2 protein kinases, regulators of translation in eukaryotes from yeasts to humans. J. Biol. Chem. 268, 7603-7606 |
15 | Xu, Z. and Williams, B. R. (1998) Genomic features of human PKR: alternative splicing and a polymorphic CGG repeat in the 5′-untranslated region. J. Interferon Cytokine Res. 18, 609-616 DOI ScienceOn |
16 | Meurs, E., Chang, K., Galabru, J., Thomas, N. S., Kerr, I. M., et al. (1990) Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell 62, 379-390 DOI ScienceOn |
17 | Abraham, N., Jaramillo, M. L., Duncan, P. I., Methot, N., Icely, P. L., et al. (1998) The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia. Exp. Cell Res. 244, 394−404 DOI ScienceOn |
18 | Lee, S. B. and Esteban, M. (1993) The interferon-induced double- stranded RNA-activated human p68 protein kinase inhibits the replication of vaccinia virus. Virology 193, 1037-1041 DOI ScienceOn |
19 | Thomis, D. C., Doohan, J. D., and Samuel, C. E. (1992) Mechanism of interferon action: cDNA structure, expression and regulation of the interferon-induced, RNA-dependent PI/eIF-2 protein kinase from human cells. Virology 188, 33-46 DOI ScienceOn |
20 | Meurs, E. F., Wantanabe, Y., Kadereit, S., Barber, G. N., Katze, M. G., et al. (1992) Constitutive expression of human double- stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth. J. Virol. 66, 5805-5814 |
21 | Meurs, E. F., Galabru, J., Barber, G. N., Katze, M. G., and Hovanessian, A. G. (1993) Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase. Proc. Natl. Acad. Sci. USA 90, 232–236 |
22 | Icely, P. L., Gross, P., Bergeron, J. J. M., Devault, A., Afar, D. E. H., et al. (1991) TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J. Biol. Chem. 266, 16073–16077 |
23 | Katze, M. G., Wambach, M., Wong, M.-L., Garfinkel, M., Meurs, E., et al. (1991) Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell free system. Mol. Cell. Biol. 11, 5497-5505 |
24 | Gale, M. Jr. and Katze, M. J. (1998) Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase. Pharmacol. Ther. 78, 29-46 DOI ScienceOn |