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Cloning and Characterization of TMPRSS6, a Novel Type 2 Transmembrane Serine Protease  

Park, Tae Joo (Department of Life Science, National Research Laboratory of Proteolysis, Gwangju Institute of Science and Technology)
Lee, Yong Jae (Department of Life Science, National Research Laboratory of Proteolysis, Gwangju Institute of Science and Technology)
Kim, Hye Jin (Department of Life Science, National Research Laboratory of Proteolysis, Gwangju Institute of Science and Technology)
Park, Hye Gyeong (Research Institute of Genetic Engineering, Pusan National University)
Park, Woo Jin (Department of Life Science, National Research Laboratory of Proteolysis, Gwangju Institute of Science and Technology)
Publication Information
Molecules and Cells / v.19, no.2, 2005 , pp. 223-227 More about this Journal
Abstract
We have identified TMPRSS6, a novel type 2 transmembrane serine protease. TMPRSS6 possesses all the signature motifs of the family of transmembrane serine proteases (TMPRSSs), including a transmembrane domain, an LDL receptor class A (LDLRA) domain, a scavenger receptor cysteine-rich (SRCR) domain, and a serine protease domain. The substrate specificity of TMPRSS6 is slightly different from those of other TMPRSS family members. Combined with the finding that TMPRSS6 is expressed strongly in the thyroid and weakly in the trachea, this may indicate that TMPRSS6 has a specialized role.
Keywords
Serine Protease; Thyroid; TMPRSS6; Trachea; Transmembrane Domain;
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