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Microalgal Biotechnology: Carotenoid Production by the Green Algae Dunaliella salina  

Jin, Eon-Seon (Environmental Science Laboratory, Korea Ocean Research and Development Institute (KORDI))
Anastasios Melis (Department of Plant and Microbial Biology, 111 Koshland Hall, University of California)
Publication Information
Biotechnology and Bioprocess Engineering:BBE / v.8, no.6, 2003 , pp. 331-337 More about this Journal
Abstract
Unicellular green algae of the genus Dunaliella thrive in extreme environmental conditions such as high salinity, low pH, high irradiance and subzero temperatures. Species of Dunaliella are well known in the alga biotechnological industry and are employed widely for the production of valuable biochemicals, such as carotenoids. Some strains of Dunaliella are cultivated commercially in large outdoor ponds and are harvested to produce dry algal meals, such as polyunsaturated fatty acids and oils for the health food industry, and coloring agents for the food and cosmetic industries. During the past decade, the advances in molecular biology and biochemistry of microalgae, along with the advances in biotechnology of microalgal mass cultivation, enabled this microalga to become a staple of commercial exploitation. In particular, the advent of molecular biology and mutagenesis in Dunaliella has permitted enhancements in the carotenoids content of this green alga, making it more attractive for biotechnological applications. Accordingly, the present review summarizes the recent developments and advances in biotechnology of carotenoid production in Dunaliella.
Keywords
biotechnology; carotenoids; Dunaliella; microalgae;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 12  (Related Records In Web of Science)
Times Cited By SCOPUS : 12
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1 Structural and geometric isomers of carotenoids in human plasma /
[ Krinsky,N.I.;M.D.Russett;G.J.Handelman;D.M.Snodderly ] / J. Nutr.   DOI
2 Update on the biological characteristics of the antioxidant micronutrients: Vitamin C, vitamin E and the carotenoids /
[ Rock,C.L.;R.A.Jacob;P.E.Bowen ] / J. Am. Diet. Assoc.   DOI   ScienceOn
3 Lutein production by Muriellopsis sp. in an outdoor tubular photobioreactor /
[ Del Campo,J.A.;H.rodriguez;J.Moreno;M.A.Vargas;J.Rivas;M.G.Guerrero ] / J. Biotechnol.   DOI   ScienceOn
4 Functional aspects of secondary carotenoids in Haematococcus lacustris (Girod) Rostafinski (Vovocales): V. Influences on photo movement /
[ Hagen,C.;W.Braune;K.Vogel;P.P.Hader ] / plant Cell Environ.   DOI   ScienceOn
5 Genetic transformation of the diatoms Cyclotella cryptica and Navicula saprophila /
[ Dunahay,T.G.;E.E.Jarvis;P.G.Rossler ] / J. Phycol.   DOI
6 Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins /
[ Snodderly,M.D. ] / Am J. Clin. Nutr.   DOI
7 Exposure to low irradiances favors the synthesis of 9-cis beta, beta-carotene in Dunaliella salina (Teod.) /
[ Orset,S.C.;A.J.Young ] / Plant Physiol.   DOI
8 Genetics of eubacterial carotenoid bisoynthesis: A colorful tale /
[ Armstrong,G.A. ] / Ann. Rev. Microbiol.
9 Analysis of the macular pigment by HPLC: Retinal distribution and age study /
[ Bone,R.A.;J.T.Landrum;L.Fernandez;S.L.Tarsis ] / Invest. Opthalmol. Vis. Sci.
10 Measurement of carotenoids, retinoids, and tocopherols in human lenses /
[ Yeum,K.J.;A.Taylor;G.Tang;R.M.Russell ] / Invest. Ophthalmol. Vis. Sci.
11 The chemistry of carotenoids and their importance in food /
[ Daun,H. ] / Clin, Nutr.
12 Carotenoids in the human macula and whole retina /
[ handelman,G.J.;E.A.Dratz;C.C.Reay;F.J.G.M.van Kuijk ] / Invest. Ophthalmol. Vis. Sci.
13 Carotenoids in the Pacific salmon during the marine period /
[ Kitahara,T. ] / Comp. Biochem. Physiol.   DOI   ScienceOn
14 Acumulation of beta-carotene in halotolerant algae: Purification and characterization of beta-carotene-rich globules from Dunaliella bardawil (Chlorophyceae) /
[ Ben-Amotz,A.;A.Katz;M.Avron ] / J. Phycol.   DOI
15 Antioxidant status in persons with and without senile cataract /
[ Jacques,P.F.;L.T.Chylack;R.B.McGandy;S.C.Hartz ] / Arch. Ophthalmol.   DOI
16 Are active oxygen species involved in induction of betacarotene in Dunaliella bardawil? /
[ Shaish,A.;M.Avron;U.Pick;A.Amotz ] / Planta
17 Isolation and functional study of photosystem Ⅰ subunits in the cyanobacterium Synechocystis sp. PCC 6803 /
[ Sun,J.;A.Ke;P.Jin;V.P.Chitnis;P.R.Chitnis ] / Methods Enzymol.   DOI
18 Genetic enginering of eukaryotic algae: progress and prospects /
[ Stevens,D.R.;S.Putron ] / J. Phycol.
19 Arabidopsis carotenoid mutants demonstrate that lutein is not essential for photosynthesis in higer plants /
[ Pogson,B.J.;K.A.McDonald;M.Truong;G.Britton;D.DellaPenna ] / Plant Cell   DOI   ScienceOn
20 Comparing carotenogenesis in Dunaliella and Haematococcus: Implcations for commercial strategies /
[ Borowitzka,M.A.;T.G.Villa(ed.)J.Abalde(ed.) ] / Profiles on Biotechnology
21 Stable integration and functional expression of flounder growth hormone gene in transformed microalga, Chlorella ellipsoidea /
[ Kim,D.H.;Y.T.Kim;J.J.Cho;J.H.Bae;S.B.Hur;I.Hwang;T.J.Choi ] / Mar. Biotechnol.   DOI
22 Carotenoid content of chlorophycean microalgae. Factors determining lutein accumulation in Muriellopsis sp. (Chlorophyta) /
[ Del Campo,J.A.;J.Moreno;H.Rodriguez;M.A.Vargas;J.Rivas;M.G.Guerrero ] / J. Biotechnol.   DOI   ScienceOn
23 Transformation of nonselectable reporter genes in marine diatoms /
[ Falciatore,A.;R.Casotti;C.Leblanc;C.Abrescia;C.Bowler ] / Mar. Biotechnol.
24 Developing nuclear transformation system for the unicellular green alga Dunaliella tertiolecta /
[ Walker,T.;D.Becker;C.Collet ] / Proceedings of 7th ISPMB
25 Chlamydomonas genetics, a tool for the study of bioenergetic pathways /
[ Hippler,M.;K.Redding;J.D.Rochaix ] / Biochim Biophys. Acta   DOI
26 Low-temperature-induced synthesis of α-carotene in the microalgae Dunaliella salina (chlorophyta) /
[ Orset,S.C.;A.J.Young ] / J. Phycol   DOI
27 Commercial production of microalgae: pond, tank, and fermenters /
[ Borowitzka,M.A. ] / J. Biotechnol.   DOI   ScienceOn
28 Commerical developments in microalgal biotechnology /
[ Apt,K.E.;P.W.Berhrens ] / J. Phycol.   DOI   ScienceOn
29 The biotechnology of cultivating the halotolerant alga Dunaliella /
[ Ben-Amotz,A.;M.Avron ] / Trends Biotechnol.   DOI   ScienceOn
30 Lower prostate caner risk in men with elevated plasma lycopene levels: results of a prospective analysis /
[ Gann,P.H.;J.ma;E.Giovannucci;W.Willett;F.M.Sacks;C.H.Hennekens;M.J.Stampfer ] / Cancer Res.
31 Xanthophylls in microalgae: from biosynthesis to biotechnological mass production and application /
[ Jin,E.S.;J.W.E.Polle;H.K.Lee;S.Hyun;M.Chang ] / J. Microbiol. Bioechnol.   과학기술학회마을
32 Alteration of stress resistance by modification of carotenoid biosynthesis in higher plants /
[ Woitsch,S.;V.Reiser;T.Gots;A.Feyel;T.Wagner;S.Romer ] / Proceedings of 7th ISPMB
33 Metabolic engineering for the production of carotenoids in non-carotenogenic bacteria and yeast /
[ Misawa,N.;H.Shimada ] / J. Biotechnol.   DOI
34 Lutein, zeaxanthin and the macular pigment /
[ Landrum,J.T.;R.Bone ] / Arch. Biochem. Biophys.   DOI   ScienceOn
35 Molecular identification of zeaxanthin epoxidase of Nicotiana plumbaginifolia, a gene involved in abscic acid biosynthesis and corresponding to ABA locus of Arabidopsis thaliana /
[ Marin,E.;L.Anussaume;A.Quesada;M.Gonneau;B.Sotta;P.Hugueney;A.Frey;A.Marion-Poll ] / EMBO J.
36 Production of new carotenoids, astaxanthin glucosides, by E. coli. transformations carrying carotenoid biosynthetic genes /
[ Yokoyama,A.;Y.Shizuri;N.Misawa ] / Tetrahedron Lett.   DOI   ScienceOn
37 Increased production of zeaxanthin and other pigments by application of genetic engineering techniques to Synechocystis sp. strain PCC6803 /
[ Lagarde,D.;L.Beuf;W.Vermaas ] / Appl. Eviron. Microbiol.   DOI
38 Stable transformation of Chlorella: Rescue of nitrate reductase-deficient mutants with the nitrate reductase gene /
[ Bawson,H.N.;R.Burlingame;A.C.Cannons ] / Cur. Microbiol.   DOI   ScienceOn
39 Involvement of zeaxanthin and of the Cbr protein in the repair of photosystem-Ⅱ from photoinhibition in the green alga Dunaliella salina /
[ Jin,E.S.;J.W.E.Polle;A.Melis ] / Biochim. Biophys. Acta   DOI   ScienceOn
40 Metabolic engineering of the terpenoid biosynthetic pathway of Escherichia coli for production of the carotenoids β-carotene and zeaxanthin /
[ Albrecht,M.;N.Misawa;G.Sandmann ] / Biotechnol. Lett.   DOI   ScienceOn
41 Trophic conversion of an obligate photoautotrophic organism through engineering /
[ Zaslavskaia,L.A.;J.C.Lippmeier;C.Shih;D.Ehrhardt;A.R.Grossman;K.E.Apt ] / Science   DOI
42 Are active oxygen species involved in induction of betacarotene in Dunaliella bardawil? /
[ Shaish,A.;M.Avron;U.Pick;A.Amotz ] / Planta
43 /
[ Borowitzka,M.A.;M.A.Borowitzka(ed.);L.J.Borowitzka(ed.) ] / Vitamins and fine chemicals from microalgae
44 Zeaxanthin accumulation in the absence of a functional xanthophyll cycle protects Chlamydomonas reinhardtii from photooxidative stress /
[ Baroli,I.;D.D.An;T.Yamane;K.K.Niyogi ] / Plant Cell   DOI   ScienceOn
45 Effect of temperature and irradiance on growth of Haematococcus pluvialis (Chlorophyceae) /
[ Fan,L.;A.Vonshak;S.Boussiba ] / J. Phycol.   DOI   ScienceOn
46 Intake of carotenoids and retinol in relation to risk of prostate cancer /
[ Giovannucci,E.;A.Ascherio;E.B.Rimm;M.J.Stampfer;G.A.Colditz;W.C.Willett ] / J. Natl. cancer Inst.   DOI
47 Production of zeaxanthin in Escherichia coli transformed with different carotenogenic plasmid /
[ Ruther,A.;N.Misawa;P.Boger;G.Sandman ] / Appl. Miocrobiol. Biotechnol.   DOI   ScienceOn
48 The biotechnology of mass culturing Dunaliella for products of commerical interest;Algal and Cyanobacterial Biotechnology /
[ Ben-Amotz,A.;M.Avron;R.C.Cresswell(ed.);T.A.V.Rees(ed.);N.Shah(ed.) ] / Longman Scientific & Technical
49 /
[ Avron,M.;A.Ben-Amotz ] / Dunaliella: Physiology, Biotechemistry, and Biotechnology
50 Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration /
[ Seddon,J.M.;U.A.Ajani;R.D.Sperduto;R.Hiller;N.Blair;T.C.Burton;M.D.Farber;E.S.gragoudas;J.Haller;D.T.Miller;L.A.Yannuzzi;W.Willett ] / J. Am. Med. Assoc.   DOI   ScienceOn
51 Production of β-carotene from Dunaliella;Chemicals from Microalgae /
[ Ben-Amotz,A.;Z.Cohen(ed.) ] / Tayler & Francis
52 The PsaD subunit of photosystem Ⅰ: mutations in the basic domain reduce the level of PsaD in the membranes /
[ Chitnis,V.P.;A.Ke;P.R.Chitnis ] / Plant Physiol.   DOI   ScienceOn
53 Altered xanthophyll compositions adversely affect chlorophyll accumulation and non-photochemica quenching in Arabidopsis mutants /
[ Pogson,B.J.;K.K.Niyogi;O.Bjorkman;D.Dellapenna ] / Proc. Natl. Acad. Sci.   DOI   ScienceOn
54 Transformation of the diatom Phaeodactylum tricornutum (Bacillariophyceae) with a variety of selectable marker and reporter genes /
[ Zaslavskaia,L.A.;J.C.Lippmeier;P.G.Kroth;A.R.Grossman;K.E.Apt ] / J. Phycol.   DOI   ScienceOn
55 Production of keto carotenoids by microalgae /
[ Margalith,P.Z. ] / App. Microbiol. Biotechnol.   DOI   ScienceOn
56 /
[ Borowitzka,M.A.;L.J.Borowitzka;M.A.Borowitzka(ed.);L.J.Borowitzka(ed.) ] / Dunaliella
57 A mutant of the green alga Dunaliella salina constitutively accumulates zeaxanthin under all growth conditions /
[ Jin,E.S.;B.Feth;A.Melis ] / Biotechnol. Bioeng.   DOI   ScienceOn
58 Natural occurrence of enantiomeric and meso astaxanthin in crustaceans including zooplankton /
[ Foss,P. ] / Comp. Biochem. Physiol.
59 Canthaxanthin biosynthesis by the conversion of methylene to keto groups in a hydrocarbon β-carotene by a single gene /
[ Misawa,N.;S.Kajiwara;K.Kondo;A.Yokoyama;Y.Satomi ] / Biochem. Biophys. Res. Comm.   DOI   ScienceOn
60 Ketocarotenoid biosynthesis outside of plastids in the unicellular green alga Haematococcus pluvialis /
[ Grunewald,K.;J.Hirschberg;C.Hagen ] / J. Biol. Chem.   DOI   ScienceOn
61 Improtance of α-carotene, β-carotene and other phytochemicals in the etiology of lung cancer /
[ Ziegler,R.G.;E.A.Colavito;P.Hartge;M.J.McAdams;J.B.Schoenberg;T.J.Mason;J.F.Fraumeni,Jr. ] / J. Natl. Cancer Inst.   DOI   ScienceOn
62 Large scale microalgal culture and applications /
[ Richmond,A.;M.Round(ed.);S.Chapman(ed.) ] / Progress in phycological Research
63 Stable nuclear transformation of diatom Phaeodactylum tricornutum /
[ Apt,K.E.;P.G.Kroth-Pacific ] / Mol. Gen. Gene.
64 Intake of specific carotenoids and lung cancer risk /
[ Le Marchand;L.J.H.Hankin;L.N.Kolonel;G.R.Beecher;L.R.Wilkens;L.P.Zhao ] / Cancer Epidemiol. Biomarkers Prev.
65 Mode of action of the massively accumulated β-carotene of Dunaliella bardawil in protecting the alga against damage by excess irradiation /
[ Ben-Amotz,A.;A.Shaish;M.Avron ] / Plant Physiol.   DOI   ScienceOn
66 Commercial potential for Haematococcus microalgae as a natural source of astaxanthin /
[ Lorenz,R.T.;G.R.Cysewski ] / Trends Biotechnol.   DOI   ScienceOn
67 New mode of Dunaliella biotechnology two-phage growth for β-carotene production /
[ Ben-Amotz,A. ] / J. Appl. Phyol.   DOI   ScienceOn