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http://dx.doi.org/10.3344/kjp.2022.35.3.250

Identification of cranial nerve ganglia using sectioned images and three-dimensional models of a cadaver  

Kim, Chung Yoh (Department of Anatomy, Dongguk University School of Medicine)
Park, Jin Seo (Department of Anatomy, Dongguk University School of Medicine)
Chung, Beom Sun (Department of Anatomy, Yonsei University Wonju College of Medicine)
Publication Information
The Korean Journal of Pain / v.35, no.3, 2022 , pp. 250-260 More about this Journal
Abstract
Background: Cranial nerve ganglia, which are prone to viral infections and tumors, are located deep in the head, so their detailed anatomy is difficult to understand using conventional cadaver dissection. For locating the small ganglia in medical images, their sectional anatomy should be learned by medical students and doctors. The purpose of this study is to elucidate cranial ganglia anatomy using sectioned images and three-dimensional (3D) models of a cadaver. Methods: One thousand two hundred and forty-six sectioned images of a male cadaver were examined to identify the cranial nerve ganglia. Using the real color sectioned images, real color volume model having a voxel size of 0.4 × 0.4 × 0.4 mm was produced. Results: The sectioned images and 3D models can be downloaded for free from a webpage, anatomy.dongguk.ac.kr/ganglia. On the images and model, all the cranial nerve ganglia and their whole course were identified. In case of the facial nerve, the geniculate, pterygopalatine, and submandibular ganglia were clearly identified. In case of the glossopharyngeal nerve, the superior, inferior, and otic ganglia were found. Thanks to the high resolution and real color of the sectioned images and volume models, detailed observation of the ganglia was possible. Since the volume models can be cut both in orthogonal planes and oblique planes, advanced sectional anatomy of the ganglia can be explained concretely. Conclusions: The sectioned images and 3D models will be helpful resources for understanding cranial nerve ganglia anatomy, for performing related surgical procedures.
Keywords
Anatomy, Cross-Sectional; Cadaver; Cranial Nerves; Dissection; Facial Nerve; Ganglia, Parasympathetic; Glossopharyngeal Nerve; Imaging, Three-Dimensional; Neuroanatomy;
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1 Moore KL, Dalley AF 2nd, Agur AM. Clinically oriented anatomy. 8th ed. Philadelphia, Lippincott Williams & Wilkins. 2018, pp 1956-7.
2 Spock T, Hoffman HT, Joshi AS. Transoral submandibular ganglion neurectomy: an anatomical feasibility study. Ann Otol Rhinol Laryngol 2015; 124: 341-4.   DOI
3 Archie KA, Marcus DS. DicomBrowser: software for viewing and modifying DICOM metadata. J Digit Imaging 2012; 25: 635-45.   DOI
4 Crespi J, Bratbak D, Dodick D, Matharu M, Jamtoy KA, Tronvik E. Prediction of the sphenopalatine ganglion localization in computerized tomography images. Cephalalgia Rep 2019. doi: 10.1177/2515816318824690.   DOI
5 Khonsary SA, Ma Q, Villablanca P, Emerson J, Malkasian D. Clinical functional anatomy of the pterygopalatine ganglion, cephalgia and related dysautonomias: a review. Surg Neurol Int 2013; 4(Suppl 6): S422-8.
6 Rusu MC, Pop F, Curca GC, Podoleanu L, Voinea LM. The pterygopalatine ganglion in humans: a morphological study. Ann Anat 2009; 191: 196-202.   DOI
7 Tepper SJ, Caparso A. Sphenopalatine ganglion (SPG): stimulation mechanism, safety, and efficacy. Headache 2017; 57 Suppl 1: 14-28.   DOI
8 Bratbak DF, Folvik M, Nordgard S, Stovner LJ, Dodick DW, Matharu M, et al. Depicting the pterygopalatine ganglion on 3 Tesla magnetic resonance images. Surg Radiol Anat 2018; 40: 689-95.   DOI
9 Saremi F, Helmy M, Farzin S, Zee CS, Go JL. MRI of cranial nerve enhancement. AJR Am J Roentgenol 2005; 185: 1487-97.   DOI
10 VandeVyver V, Lemmerling M, Van Hecke W, Verstraete K. MRI findings of the normal and diseased trigeminal nerve ganglion and branches: a pictorial review. JBR-BTR 2007; 90: 272-7.
11 An JX, Liu H, Chen RW, Wang Y, Zhao WX, Eastwood D, et al. Computed tomography-guided percutaneous ozone injection of the Gasserian ganglion for the treatment of trigeminal neuralgia. J Pain Res 2018; 11: 255-63.   DOI
12 Park JS, Chung MS, Hwang SB, Lee YS, Har DH, Park HS. Visible Korean human: improved serially sectioned images of the entire body. IEEE Trans Med Imaging 2005; 24: 352-60.   DOI
13 Kim CY, Jung YW, Park JS. The Visible Korean: movable surface models of the hip joint. Surg Radiol Anat 2021; 43: 559-66.   DOI
14 Chung BS, Park JS. Real-color volume models made from real-color sectioned images of Visible Korean. J Korean Med Sci 2019; 34: e86.   DOI
15 You Y, Kim CY, Kim SK, Chung BS, Har D, Choi J, et al. Advanced-sectioned images obtained by microsectioning of the entire male body. Clin Anat 2022; 35: 79-86.   DOI
16 Senger M, Stoffels HJ, Angelov DN. Topography, syntopy and morphology of the human otic ganglion: a cadaver study. Ann Anat 2014; 196: 327-35.   DOI
17 Piagkou M, Demesticha T, Troupis T, Vlasis K, Skandalakis P, Makri A, et al. The pterygopalatine ganglion and its role in various pain syndromes: from anatomy to clinical practice. Pain Pract 2012; 12: 399-412. Erratum in: Pain Pract 2012; 12: 673.   DOI
18 Siessere S, Vitti M, Sousa LG, Semprini M, Iyomasa MM, Regalo SC. Anatomic variation of cranial parasympathetic ganglia. Braz Oral Res 2008; 22: 101-5.   DOI
19 Tesapirat L, Jariyakosol S, Chentanez V. Morphometric study of the ciliary ganglion and its pertinent intraorbital procedure. Folia Morphol (Warsz) 2020; 79: 438-44.   DOI
20 Hamzaoglu V, Beger O, Erdogan O, Kara E, Vayisoglu Y, Taghipour P, et al. Radioanatomic assessment of the geniculate ganglion dehiscence and dimension: a cadaveric study. World Neurosurg 2020; 134: e913-9.   DOI
21 Zhang L, Chen S, Sun Y. Mechanism and prevention of spiral ganglion neuron degeneration in the cochlea. Front Cell Neurosci 2022; 15: 814891.   DOI
22 Guillotte A, Zand A, Ortiz M, Gan Y, Rivera A, Litofsky NS, et al. Clinical outcomes of resecting scarpa's ganglion during vestibular schwannoma surgery. J Clin Neurosci 2020; 76: 114-7.   DOI
23 de Bree R, van der Waal I, Leemans CR. Management of Frey syndrome. Head Neck 2007; 29: 773-8.   DOI
24 Crespi J, Bratbak D, Dodick DW, Matharu MS, Senger M, Angelov DN, et al. Anatomical landmarks for localizing the otic ganglion: a possible new treatment target for headache disorders. Cephalalgia Rep 2019. doi: 10.1177/2515816319850761.   DOI
25 Crespi J, Bratbak D, Dodick DW, Matharu M, Solheim O, Gulati S, et al. Open-label, multi-dose, pilot safety study of injection of onabotulinumtoxinA toward the otic ganglion for the treatment of intractable chronic cluster headache. Headache 2020; 60: 1632-43.   DOI
26 Miller RB, Boon MS, Atkins JP, Lowry LD. Vagal paraganglioma: the Jefferson experience. Otolaryngol Head Neck Surg 2000; 122: 482-7.   DOI
27 Park JS, Chung MS, Hwang SB, Lee YS, Har DH. Technical report on semiautomatic segmentation using the Adobe Photoshop. J Digit Imaging 2005; 18: 333-43.   DOI
28 Sinnreich Z, Nathan H. The ciliary ganglion in man (anatomical observations). Anat Anz 1981; 150: 287-97.
29 Franzini A, Messina G, Franzini A, Marchetti M, Ferroli P, Fariselli L, et al. Treatments of glossopharyngeal neuralgia: towards standard procedures. Neurol Sci 2017; 38(Suppl 1): 51-5.   DOI
30 Li X, Morgan PS, Ashburner J, Smith J, Rorden C. The first step for neuroimaging data analysis: DICOM to NIfTI conversion. J Neurosci Methods 2016; 264: 47-56.   DOI
31 Tubbs RS, Mortazavi MM, Krishnamurthy S, Verma K, Griessenauer CJ, Cohen-Gadol AA. The relationship between the superior petrosal sinus and the porus trigeminus: an anatomical study. J Neurosurg 2013; 119: 1221-5.   DOI
32 Lan MY, Shiao JY. Using greater superficial petrosal nerve and geniculate ganglion as the only two landmarks for identifying internal auditory canal in middle fossa approach. Eur Arch Otorhinolaryngol 2010; 267: 1867-71.   DOI
33 Mancall EL, Brock DG. Cervical plexus. In: Gray's clinical neuroanatomy: the anatomic basis for clinical neuroscience. Edited by Mancall EL, Brock DG. Philadelphia, Elsevier Health Sciences. 2011, pp 315-7.
34 Rong Z, Zixiang Y, Chang L, Guoxing X, Sheng Z, Yuanteng X, et al. Lacrimal hyposecretion: a surgical complication of juvenile nasopharyngeal angiofibroma. Am J Otolaryngol 2008; 29: 367-71.   DOI
35 Mei X, Glueckert R, Schrott-Fischer A, Li H, Ladak HM, Agrawal SK, et al. Vascular supply of the human spiral ganglion: novel three-dimensional analysis using synchrotron phase-contrast imaging and histology. Sci Rep 2020; 10: 5877. Erratum in: Sci Rep 2020; 10: 7681.   DOI
36 Wu YW, Karandikar A, Goh JP, Tan TY. Imaging features differentiating vestibular ganglion from intracanalicular schwannoma on single-sequence non-contrast magnetic resonance imaging study. Ann Acad Med Singap 2020; 49: 65-71.   DOI
37 Tolba R, Weiss AL, Denis DJ. Sphenopalatine ganglion block and radiofrequency ablation: technical notes and efficacy. Ochsner J 2019; 19: 32-7.   DOI
38 Song MH, Lee HY, Jeon JS, Lee JD, Lee HK, Lee WS. Jugular foramen schwannoma: analysis on its origin and location. Otol Neurotol 2008; 29: 387-91.   DOI
39 Roh TH, Oh JW, Jang CK, Choi S, Kim EH, Hong CK, et al. Virtual dissection of the real brain: integration of photographic 3D models into virtual reality and its effect on neurosurgical resident education. Neurosurg Focus 2021; 51: E16.