Effects of Nefopam on Streptozotocin-Induced Diabetic Neuropathic Pain in Rats |
Nam, Jae Sik
(Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Cheong, Yu Seon (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine) Karm, Myong Hwan (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine) Ahn, Ho Soo (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine) Sim, Ji Hoon (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine) Kim, Jin Sun (Gangneung Asan Hospital, University of Ulsan College of Medicine) Choi, Seong Soo (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine) Leem, Jeong Gil (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine) |
1 | Durrieu G, Olivier P, Bagheri H, Montastruc JL; French Network of Pharmacovigilance Centers. Overview of adverse reactions to nefopam: an analysis of the French Pharmacovigilance database. Fundam Clin Pharmacol 2007; 21: 555-8. DOI ScienceOn |
2 | Girard P, Coppe MC, Verniers D, Pansart Y, Gillardin JM. Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception. Pharmacol Res 2006; 54: 195-202. DOI ScienceOn |
3 | Biella GE, Groppetti A, Novelli A, Fernandez-Sanchez MT, Manfredi B, Sotgiu ML. Neuronal sensitization and its behavioral correlates in a rat model of neuropathy are prevented by a cyclic analog of orphenadrine. J Neurotrauma 2003; 20: 593-601. DOI ScienceOn |
4 | Saghaei E, Moini Zanjani T, Sabetkasaei M, Naseri K. Enhancement of antinociception by co-administrations of nefopam, morphine, and nimesulide in a rat model of neuropathic pain. Korean J Pain 2012; 25: 7-15. DOI |
5 | Schnedl WJ, Ferber S, Johnson JH, Newgard CB. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes 1994; 43: 1326-33. DOI |
6 | Sima AA, Sugimoto K. Experimental diabetic neuropathy: an update. Diabetologia 1999; 42: 773-88. DOI |
7 | Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997; 389: 816-24. DOI ScienceOn |
8 | Wei H, Hamalainen MM, Saarnilehto M, Koivisto A, Pertovaara A. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 2009; 111: 147-54. DOI |
9 | Koivisto A, Hukkanen M, Saarnilehto M, Chapman H, Kuokkanen K, Wei H, et al. Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy. Pharmacol Res 2012; 65: 149-58. DOI |
10 | Wei H, Chapman H, Saarnilehto M, Kuokkanen K, Koivisto A, Pertovaara A. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology 2010; 58: 578-84. DOI |
11 | Xing H, Chen M, Ling J, Tan W, Gu JG. TRPM8 mechanism of cold allodynia after chronic nerve injury. J Neurosci 2007; 27: 13680-90. DOI |
12 | Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53: 55-63. DOI ScienceOn |
13 | Laboureyras E, Chateauraynaud J, Richebe P, Simonnet G. Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. Anesth Analg 2009; 109: 623-31. DOI ScienceOn |
14 | Kim SH, Nam JS, Choi DK, Koh WW, Suh JH, Song JG, et al. Tumor necrosis factor-alpha and apoptosis following spinal nerve ligation injury in rats. Korean J Pain 2011; 24: 185-90. DOI |
15 | Li Y, Dorsi MJ, Meyer RA, Belzberg AJ. Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers. Pain 2000; 85: 493-502. DOI ScienceOn |
16 | Choi SS, Koh WU, Nam JS, Shin JW, Leem JG, Suh JH. Effect of ethyl pyruvate on Paclitaxel-induced neuropathic pain in rats. Korean J Pain 2013; 26: 135-41. DOI |
17 | Sigaudo-Roussel D, Fromy B, Saumet JL. Diabetic neuropathy in animal models. Drug Discov Today Dis Models 2007; 4: 39-44. DOI |
18 | Leurs R, Donnell D, Timmerman H, Bast A. Cytochrome P450 metabolic intermediate complex of nefopam. J Pharm Pharmacol 1987; 39: 835-7. DOI |
19 | Wrigley PJ, Jeong HJ, Vaughan CW. Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones. Br J Pharmacol 2009; 157: 371-80. DOI |
20 | Knowlton WM, Bifolck-Fisher A, Bautista DM, McKemy DD. TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain 2010; 150: 340-50. DOI ScienceOn |
21 | Colburn RW, Lubin ML, Stone DJ Jr, Wang Y, Lawrence D, D'Andrea MR, et al. Attenuated cold sensitivity in TRPM8 null mice. Neuron 2007; 54: 379-86. DOI ScienceOn |
22 | Kim SH, Kwon JK, Kwon YB. Pain modality and spinal glia expression by streptozotocin induced diabetic peripheral neuropathy in rats. Lab Anim Res 2012; 28: 131-6. DOI |
23 | Klein AH, Sawyer CM, Carstens MI, Tsagareli MG, Tsiklauri N, Carstens E. Topical application of L-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats. Behav Brain Res 2010; 212: 179-86. DOI |
24 | Namer B, Seifert F, Handwerker HO, Maihofner C. TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. Neuroreport 2005; 16: 955-9. DOI |
25 | Proudfoot CJ, Garry EM, Cottrell DF, Rosie R, Anderson H, Robertson DC, et al. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 2006; 16: 1591-605. DOI |
26 | Talbot S, Chahmi E, Dias JP, Couture R. Key role for spinal dorsal horn microglial kinin B1 receptor in early diabetic pain neuropathy. J Neuroinflammation 2010; 7: 36. DOI ScienceOn |
27 | Girard P, Pansart Y, Coppe MC, Gillardin JM. Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat. Pharmacol Res 2001; 44: 541-5. DOI ScienceOn |
28 | Su L, Wang C, Yu YH, Ren YY, Xie KL, Wang GL. Role of TRPM8 in dorsal root ganglion in nerve injury-induced chronic pain. BMC Neurosci 2011; 12: 120. DOI |
29 | Verleye M, Andre N, Heulard I, Gillardin JM. Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res 2004; 1013: 249-55. DOI ScienceOn |
30 | Brederson JD, Kym PR, Szallasi A. Targeting TRP channels for pain relief. Eur J Pharmacol 2013; 716: 61-76. DOI |
31 | Barriere DA, Rieusset J, Chanteranne D, Busserolles J, Chauvin MA, Chapuis L, et al. Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization. Pain 2012; 153: 553-61. DOI |
32 | Calcutt NA. Potential mechanisms of neuropathic pain in diabetes. Int Rev Neurobiol 2002; 50: 205-28. DOI |
![]() |