Antinociceptive Effects of Intraperitoneal and Intrathecal Vitamin E in the Rat Formalin Test
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Kim, Myoung-Joong
(Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital)
Hong, Boo-Hwi (Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital) Zhang, En-Ji (Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital) Ko, Young-Kwon (Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital) Lee, Won-Hyung (Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital) |
1 | Nishiyama T. Interaction between intrathecal morphine and glutamate receptor antagonists in formalin test. Eur J Pharmacol 2000; 395: 203-210. DOI ScienceOn |
2 | Cuesta MC, Arcaya JL, Cano G, Sanchez L, Maixner W, Suarez-Roca H. Opposite modulation of capsaicin-evoked substance P release by glutamate receptors. Neurochem Int 1999; 35: 471-478. DOI ScienceOn |
3 | Lee KY, Chung K, Chung JM. Involvement of reactive oxygen species in long-term potentiation in the spinal cord dorsal horn. J Neurophysiol 2010; 103: 382-391. DOI ScienceOn |
4 | Reynolds IJ, Hastings TG. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J Neurosci 1995; 15: 3318-3327. |
5 | Gao X, Kim HK, Chung JM, Chung K. Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats. Pain 2005; 116: 62-72. DOI ScienceOn |
6 | Zou X, Lin Q, Willis WD. Enhanced phosphorylation of NMDA receptor 1 subunits in spinal cord dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats. J Neurosci 2000; 20: 6989-6997. |
7 | Gao X, Kim HK, Chung JM, Chung K. Reactive oxygen species (ROS) are involved in enhancement of NMDAreceptor phosphorylation in animal models of pain. Pain 2007; 131: 262-271. DOI ScienceOn |
8 | Lee I, Kim HK, Kim JH, Chung K, Chung JM. The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain 2007; 133: 9-17. DOI ScienceOn |
9 | Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E, et al. A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther 2004; 309: 869-878. DOI ScienceOn |
10 | Yoon MH, Bae HB, Choi JI. Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test. J Korean Med Sci 2005; 20: 307-312. DOI ScienceOn |
11 | Kim HK, Park SK, Zhou JL, Taglialatela G, Chung K, Coggeshall RE, et al. Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain 2004; 111: 116-124. DOI ScienceOn |
12 | Balazs L, Leon M. Evidence of an oxidative challenge in the Alzheimer's brain. Neurochem Res 1994; 19: 1131-1137. DOI ScienceOn |
13 | Olanow CW. An introduction to the free radical hypothesis in Parkinson's disease. Ann Neurol 1992; 32 Suppl: S2-S9. |
14 | Park ES, Gao X, Chung JM, Chung K. Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons. Neurosci Lett 2006; 391: 108-111. DOI ScienceOn |
15 | Hong BH, Ko YK, Lee YJ, Han K, Kim Y, Lee W. Antinociceptive effects of vitamin E in formalin-induced nociceptive response in rats. Anesth Pain Med 2011; 6: 59-62. |
16 | Tiwari V, Kuhad A, Chopra K. Tocotrienol ameliorates behavioral and biochemical alterations in the rat model of alcoholic neuropathy. Pain 2009; 145: 129-135. DOI ScienceOn |
17 | Kuhad A, Chopra K. Tocotrienol attenuates oxidative-nitrosative stress and inflammatory cascade in experimental model of diabetic neuropathy. Neuropharmacology 2009; 57: 456-462. DOI ScienceOn |
18 | Rosland JH, Tjølsen A, Maehle B, Hole K. The formalin test in mice: effect of formalin concentration. Pain 1990; 42: 235-242. DOI ScienceOn |
19 | Kim HK, Kim JH, Gao X, Zhou JL, Lee I, Chung K, et al. Analgesic effect of vitamin E is mediated by reducing central sensitization in neuropathic pain. Pain 2006; 122: 53-62. DOI ScienceOn |
20 | Hacimuftuoglu A, Handy CR, Goettl VM, Lin CG, Dane S, Stephens RL Jr. Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice. Behav Brain Res 2006; 173: 211-216. DOI ScienceOn |
21 | Coderre TJ, Vaccarino AL, Melzack R. Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection. Brain Res 1990; 535: 155-158. DOI ScienceOn |
22 | Tjolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain 1992; 51: 5-17. DOI ScienceOn |
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