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Evaluation for the Effects of Intrathecal Sildenafil on the Formalin- and Thermal-induced Nocieption of Rats  

Yoon, Myung Ha (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University)
Bae, Hong Buem (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University)
Shin, Dong Jin (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University)
Kim, Chang Mo (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University)
Jeong, Sung Tae (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University)
Kim, Seok Jai (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University)
Choi, Jeong Il (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University)
Publication Information
The Korean Journal of Pain / v.19, no.1, 2006 , pp. 17-21 More about this Journal
Abstract
Background: Cyclic guanosine monophosphate (cGMP) plays an important role in the modulation of nociception. Although local sildenafil produces antinociception, by increasing cGMP through the inhibition of phosphodiesterase 5, the effect of spinal sildenafil has not been determined. The authors evaluated the effects of intrathecal sildenafil on the nociceptive behavior evoked by formalin injection and thermal stimulation. Methods: Lumbar intrathecal catheters were implanted into rats, with formalin and Hot-Box tests used as nociceptive models. The formalin-induced nociceptive behavior (flinching response) and withdrawal latency to radiant heat were measured, and the general behaviors also observed. Results: The intrathecal administration of sildenafil produced dose-dependent suppression of the flinches in both phases in the formalin test, and increased the withdrawal latency in the Hot-Box test. No abnormal behaviors were noted. Conclusions: Sildenafil, an inhibitor of phosphodiesterase 5, is active against the nociceptive state evoked in the spinal cord by formalin and thermal stimulations. Accordingly, spinal sildenafil may be useful in the management of pain.
Keywords
antinociception; cyclic guanosine monophosphate; phosphodiesterase; sildenafil; spinal cord;
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Times Cited By KSCI : 2  (Citation Analysis)
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