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Treatment of Persistent Hiccups with a Single Session of Gabapentin Therapy -A report of 2 cases-  

You, Sie Hyun (Department of Anesthesiology and Pain Medicine, College of Medicine, Soonchunhyang University)
Kim, Chun Sook (Department of Anesthesiology and Pain Medicine, College of Medicine, Soonchunhyang University)
Kim, Bung Heum (Department of Orthopedics, College of Medicine, Soonchunhyang University)
Seo, Hwan Joo (Department of Anesthesiology and Pain Medicine, College of Medicine, Soonchunhyang University)
Kang, Kyu Sik (Department of Anesthesiology and Pain Medicine, College of Medicine, Soonchunhyang University)
Publication Information
The Korean Journal of Pain / v.18, no.2, 2005 , pp. 222-225 More about this Journal
Abstract
Hiccups are due to an intermittent clonic spasm of the diaphragm. In most cases, hiccups are self-limiting disease, but persistent hiccups may be related to the presence of serious underlying systemic disease. Two patients who had persistent hiccups that were not controled by conventional methods and medications were referred to the pain clinic. We administered a single oral medication of gabapentin, and then the hiccups disappeared in both cases. We concluded that gabapentin should be considered as an alternative therapy to control persistent or intractable hiccup. It could be particularly useful for those patients with solid malignancies, either alone or as an "add-on therapy" with other oral agents.
Keywords
gabapentin; persistent hiccups;
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1 Pollack MJ: Intractable hiccups: a serious sign of underlying systemicdisease. J Clin Gastroenterol 2003; 37: 272-3.
2 Friedman NL: Hiccups: a treatment review. Pharmacotherapy 1996; 16: 986-95.
3 Davis IN: An experimental syudy of hiccup. Brain 1970; 93: 851-72.
4 Lewis JH: Hiccups: causes and cures. J Clin Gastroenterol 1985; 7: 539-52.
5 Lee JH, Kim JI, Min BW: Persistent hiccups treatment with cervical epidural block: case reports. Korean J Pain 1997; 10: 241-5.
6 Petroianu G, Hein G, Stegmeier-Petroianu A, Bergler W, Rufer R: Gabapentin "add-on therapy" for idiopathic chronic hiccup (ICH). J Clin Gasrroenterol 2000; 30: 321-4.
7 Duffy MC, Edmond H, Campbell K, Fulton JD: Hiccough relief with cisapride. Lancet 1992; 340: 1223.
8 Hernandez JL, Pajaron M, Garcia-Regata 0, Jimenez V, Gonzalez-Macias J, Ramos-Estebanez C: Gabapentin for intractable hiccup. Am J Med 2004; 117: 279-81.
9 Van Hooft JA, Dougherty JJ, Endeman D, Nichols RA, Wadman WJ: Gabapenrin inhibits presynaptic Ca (2 +) influx and synaptic transmission in tat hippocampus and neocortex. Eur J Pharmacal 2002; 449: 221-8.
10 Porzio G, Aielli F, Narducci F, Varrassi G, Ricevuro E, Picorella C, er al: Hiccup in patients with advanced cancer successfully treated with gabapentin: report of three cases. N Z Med J 2003; 116: 605-7.
11 Guelaud C, Similowski T, Bizec JL, Cabane J, Whitelaw WA, Derenne JP: Baclofen therapy for chronic hiccup. Eur Respir J 1995; 8: 235-7.
12 Samuels L: Hicuup; a ten year review of anaromy, etiology, and treatment. Can Med Assoc J 1952; 67: 315-22.
13 Mayo CW: Hiccup. Surg Gynecol Obstet 1932; 55: 700-8.
14 Ramirez FC, Graham DY: Treatment of intractable hiccup with baclofen: results of a double-blind randomized, controlled, cross-over study. Am J Gastroenrerol 1992; 87: 1789-91.
15 Shin CH,Seo SJ, Choi HG, Kim OS, Ryu SJ, Jang TH: Management of intractable hiccups: a report of 3 cases. Korean J Pain 2004; 17: 88-91.
16 Choi JH, Lee JY, Lee JY, Sung CH: Persistent hiccup after epidural steroid injection case reports. Korean J Pain 2004; 17: 312-4.
17 Yang NY, Moon DE, Shim JY, Park C], Kwon OK, Park CM, et al: Trcarment of intractable hiccup with midazolam and baclofen: case report. Korean J Pain 1997; 10: 246-9.
18 Kolodzik PW, Eilers MA: Hiccups (singultus): a review and approach to management. Ann Emerg Med 1991; 20: 565-73.
19 Karian JM, Buchheit WA: Intractable hiccup as a complication of ventriculo-peritoneal shunt: case report. Neurosurgery 1980; 7: 283-4.
20 Priebe MM, Sherwood AM, Graves DE, Mueller M, Olson WH: Effectiveness of gabapentin in controlling spasticity: a quantitative study. Spinal Cord 1997; 35: 171-5.