Browse > Article
http://dx.doi.org/10.5223/pghn.2021.24.5.483

The Relationship between Daily Fructose Consumption and Oxidized Low-Density Lipoprotein and Low-Density Lipoprotein Particle Size in Children with Obesity  

Gungor, Ali (Department of Pediatrics, Gulhane Faculty of Medicine, University of Health Sciences)
Balamtekin, Necati (Division of Pediatric Gastroenterology, Department of Pediatrics, Gulhane Faculty of Medicine, University of Health Sciences)
Ozkececi, Coskun Firat (Department of Pediatrics, Gulhane Faculty of Medicine, University of Health Sciences)
Aydin, Halil Ibrahim (Department of Pediatric Nutrition and Metabolism Diseases, School of Medicine, Baskent University)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.24, no.5, 2021 , pp. 483-491 More about this Journal
Abstract
Purpose: Obesity has become a very significant health problem in childhood. Fructose taken in an uncontrolled manner and consumed in excessive amounts is rapidly metabolized in the body and gets converted into fatty acids. This single center prospective case-control study aims to investigate the relationship between fructose consumption and obesity and the role of fructose consumption in development of atherosclerotic diseases. Methods: A total of 40 obese and 40 healthy children who were of similar ages (between 8 and 18 years) and sexes were included in the study. In the patient and control groups, the urine fructose levels, as well as the levels of oxidized low-density lipoprotein (LDL), small dense LDL, Apolipoprotein A and Apolipoprotein B values, which have been shown to play a role in development of atherosclerotic diseases, were measured. Results: The levels of oxidized LDL and small dense LDL and the ratio of Apolipoprotein A/Apolipoprotein B were found to be significantly higher in the patient group. Conclusion: We found that urinary fructose levels were higher in the obese children than the healthy children. Our results suggest that overconsumption of fructose in children triggers atherogenic diseases by increasing the levels of small dense LDL and oxidized LDL and the ratio of Apolipoprotein B/Apolipoprotein A.
Keywords
Eating; Dyslipidemias; Fructose; Child; Obesity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Wang HH, Garruti G, Liu M, Portincasa P, Wang DQ. Cholesterol and lipoprotein metabolism and atherosclerosis: recent advances in reverse cholesterol transport. Ann Hepatol 2017;16(Suppl. 1: s3-105):s27-42.   DOI
2 Linton MRF, Yancey PG, Davies SS, Jerome WG, Linton EF, Song WL, et al. The role of lipids and lipoproteins in atherosclerosis. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dhatariya K, et al., eds. Endotext. South Dartmouth: MDText.com, Inc., 2000.
3 Packard CJ. Triacylglycerol-rich lipoproteins and the generation of small, dense low-density lipoprotein. Biochem Soc Trans 2003;31(Pt 5):1066-9.   DOI
4 Sacks FM, Campos H. Clinical review 163: cardiovascular endocrinology: low-density lipoprotein size and cardiovascular disease: a reappraisal. J Clin Endocrinol Metab 2003;88:4525-32.   DOI
5 Deric MJ. Pathophysiology and clinical significance of atherogenic lipoprotein phenotype and small dense LDL particles. Jugosl Med Biohemija 2003;22:101-7.   DOI
6 Watanabe T, Koba S, Kawamura M, Itokawa M, Idei T, Nakagawa Y, et al. Small dense low-density lipoprotein and carotid atherosclerosis in relation to vascular dementia. Metabolism 2004;53:476-82.   DOI
7 Songul Yalcin S, Tugrul B, Nacar N, Tuncer M, Yurdakok K. Factors that affect television viewing time in preschool and primary schoolchildren. Pediatr Int 2002;44:622-7.   DOI
8 Johner SA, Libuda L, Shi L, Retzlaff A, Joslowski G, Remer T. Urinary fructose: a potential biomarker for dietary fructose intake in children. Eur J Clin Nutr 2010;64:1365-70.   DOI
9 Hallfrisch J, Reiser S, Prather ES. Blood lipid distribution of hyperinsulinemic men consuming three levels of fructose. Am J Clin Nutr 1983;37:740-8.   DOI
10 Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004;79:537-43.   DOI
11 Ross AP, Bartness TJ, Mielke JG, Parent MB. A high fructose diet impairs spatial memory in male rats. Neurobiol Learn Mem 2009;92:410-6.   DOI
12 Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J 2017;38:2459-72.   DOI
13 Steinberg D, Witztum JL. Oxidized low-density lipoprotein and atherosclerosis. Arterioscler Thromb Vasc Biol 2010;30:2311-6.   DOI
14 Spruss A, Bergheim I. Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease. J Nutr Biochem 2009;20:657-62.   DOI
15 Rodwell VW, Bender DA, Botham KM, Kennelly PJ, Weil PA. Harper's illustrated biochemistry. 30th ed. New York: Mcgraw-Hill, 2015.
16 Schaftenaar F, Frodermann V, Kuiper J, Lutgens E. Atherosclerosis: the interplay between lipids and immune cells. Curr Opin Lipidol 2016;27:209-15.   DOI
17 Austin MA, Breslow JL, Hennekens CH, Buring JE, Willett WC, Krauss RM. Low-density lipoprotein subclass patterns and risk of myocardial infarction. JAMA 1988;260:1917-21.   DOI
18 Wallenfeldt K, Bokemark L, Wikstrand J, Hulthe J, Fagerberg B. Apolipoprotein B/apolipoprotein A-I in relation to the metabolic syndrome and change in carotid artery intima-media thickness during 3 years in middle-aged men. Stroke 2004;35:2248-52.   DOI
19 Aeberli I, Zimmermann MB, Molinari L, Lehmann R, l'Allemand D, Spinas GA, et al. Fructose intake is a predictor of LDL particle size in overweight schoolchildren. Am J Clin Nutr 2007;86:1174-8.   DOI
20 Sierra-Johnson J, Somers VK, Kuniyoshi FH, Garza CA, Isley WL, Gami AS, et al. Comparison of apolipoprotein-B/apolipoprotein-AI in subjects with versus without the metabolic syndrome. Am J Cardiol 2006;98:1369-73.   DOI
21 Korkmaz A. [Fructose; a hidden threat for chronic diseases]. Turk Silahli Kuvvetleri Koruyucu Hekim Bul 2008;7:343-6. Turkish
22 Sarbat G, Demirkol M. Obezite. In: Eksi A, ed. Ben hasta degilim: cocuk sagligi ve hastaliklarinin psikososyal yonu. Istanbul: Nobel Tip Kitabevleri, 1999:441-50. Turkish.
23 Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics 2005;116:473-80.   DOI
24 Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M, et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 2004;89:2963-72.   DOI
25 Stanhope KL, Havel PJ. Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance. Curr Opin Lipidol 2008;19:16-24.   DOI
26 Matyka K. Practical Endocrinology and Diabetes in Children. By Joseph E Raine, Malcolm DC Donaldson, John W Gregory and Guy Van Vliet. 3rd Edition, 2011 Published by Wiley-Blackwell Price: 272 pages ISBN: 978 1 4051 9634 5 Website: www.wiley.com. Pract Diabetes 2011;28:304.   DOI
27 Simopoulos AP. Essential fatty acids in health and chronic disease. Am J Clin Nutr 1999;70(3 Suppl):560S-569S.   DOI