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http://dx.doi.org/10.5223/pghn.2021.24.5.470

Relationship between Quantitative Sonographic Measurements and Serum Biochemical Parameters in Childhood Obesity  

Damar, Cagri (Department of Pediatric Radiology, Faculty of Medicine, Gaziantep University)
ISik, Emregul (Clinics of Pediatric Endocrinology, Department of Pediatrics, Gaziantep Children's Hospital)
Gungor, Sukru (Clinics of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Faculty of Medicine, Kahramanmaras Sutcu Imam University)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.24, no.5, 2021 , pp. 470-482 More about this Journal
Abstract
Purpose: We investigated the relationship between sonographic measurements of fatty liver and body mass index standard deviation score (BMI-Z score), abdominal wall fat thickness (AWFT), and serum biochemical parameters in childhood obesity. Methods: Anthropometric, laboratory, and ultrasonography data were obtained from 174 children with BMI-Z score >1. After the qualitative grading of hepatosteatosis (grades 0-3), the quantitative liver-kidney echogenicity ratio (LKER) was calculated using a software tool. Groups according to sex, age (AG-I to AG-III), BMI-Z score (BMG-I to BMG-III), and hepatosteatosis degree (HS-I and HS-II) were formed. The differences and distributions of the variables were statistically analyzed and compared among the groups. Results: Serum transaminase and glucose levels showed a positive correlation with LKER, whereas the HDL level showed a negative correlation. BMI-Z score and AWFT showed a positive correlation with fasting insulin level and HOMA-IR value. LKER was significantly higher in girls than in boys (p=0.008). In the AG-I group (age 3-8.9 years), the BMI-Z score was significantly higher, whereas AWFT was significantly lower than in the other age groups (p<0.001). The cutoff point of LKER for predicting grade 2 or higher steatosis (HS-II group) was determined to be 1.83. Cardiovascular disease risk was significantly higher in the HS-II group (p=0.035). Conclusion: As a valuable quantitative measurement tool, LKER can be used for the sonographic screening of fatty liver. AWFT, on the basis of its correlation with fasting insulin level and HOMA-IR value, may be a useful sonographic parameter in the management of childhood obesity.
Keywords
Ultrasonography; Pediatrics; Childhood obesity; Hepatic steatosis; Anthropometry;
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