Browse > Article
http://dx.doi.org/10.5223/pghn.2019.22.3.249

Visual Hyper-vigilance But Insufficient Mental Representation in Children with Overweight/Obesity: Event-related Potential Study with Visual Go/NoGo Test  

Gill, Inkyu (Department of Pediatrics, Hanyang University University Guri Hospital)
Moon, Jin-Hwa (Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine)
Kim, Yong Joo (Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine)
Kim, Ja Hye (Department of Pediatrics, Hanyang University University Guri Hospital)
Ahn, Dong Hyun (Department of Psychiatry, Hanyang University Medical Center, Hanyang University College of Medicine)
Koh, Min Sook (Department of Pediatrics, Hanyang University University Guri Hospital)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.22, no.3, 2019 , pp. 249-261 More about this Journal
Abstract
Purpose: The neural processing of children with overweight/obesity (CWO), may affect their eating behavior. We investigated the visual information processing of CWO under response control condition, by event-related potential (ERP) study, an electrophysiologic study for cognitive mechanism. Methods: Seventeen CWO (mean age: $10.6{\pm}1.9$), and 17 age-matched non-obese children (NOC), participated in the study. Neurocognitive function tests and visual ERP under Go/NoGo conditions, were implemented. Area amplitudes of major ERP components (P1, N1, P2, N2, and P3) from four scalp locations (frontal, central, parietal, and occipital), were analyzed. Results: For Go and NoGo conditions, CWO had significantly greater occipital P1, frontocentral N1, and P2 amplitudes compared with NOC. P2 amplitude was significantly greater in CWO, than in NOC, at the frontal location. N2 amplitude was not significantly different, between CWO and NOC. For CWO and NOC, Go P3 amplitude was highest at the parietal location, and NoGo P3 amplitude was highest at the frontal location. In Go and NoGo conditions, P3 amplitude of CWO was significantly less than in NOC. Conclusion: The greater P1, N1, and P2 suggested hyper-vigilance to visual stimuli of CWO, but the smaller P3 suggested insufficient mental representation of them. Such altered visual processing, may affect the eating behavior of CWO.
Keywords
Children; Obesity; Event-related potential; Go/NoGo; Visual;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Pulgaron ER. Childhood obesity: a review of increased risk for physical and psychological comorbidities. Clin Ther 2013;35:A18-32.   DOI
2 Khan NA, Raine LB, Donovan SM, Hillman CH. IV. The cognitive implications of obesity and nutrition in childhood. Monogr Soc Res Child Dev 2014;79:51-71.
3 Agusti A, Garcia-Pardo MP, Lopez-Almela I, Campillo I, Maes M, Romani-Perez M, et al. Interplay between the gut-brain axis, obesity and cognitive function. Front Neurosci 2018;12:155.   DOI
4 Hofmann J, Ardelt-Gattinger E, Paulmichl K, Weghuber D, Blechert J. Dietary restraint and impulsivity modulate neural responses to food in adolescents with obesity and healthy adolescents. Obesity (Silver Spring) 2015;23:2183-9.   DOI
5 Park EH, Oh MS, Kim S, Lee J, Kang KS. The analysis of factors causing the high prevalence of child obesity in Jeju island. Pediatr Gastroenterol Hepatol Nutr 2018;21:127-33.   DOI
6 Pauli-Pott U, Albayrak O, Hebebrand J, Pott W. Association between inhibitory control capacity and body weight in overweight and obese children and adolescents: dependence on age and inhibitory control component. Child Neuropsychol 2010;16:592-603.   DOI
7 Wirt T, Schreiber A, Kesztyus D, Steinacker JM. Early life cognitive abilities and body weight: cross-sectional study of the association of inhibitory control, cognitive flexibility, and sustained attention with BMI percentiles in primary school children. J Obes 2015;2015:534651.   DOI
8 Carbine KA, Duraccio KM, Kirwan CB, Muncy NM, LeCheminant JD, Larson MJ. A direct comparison between ERP and fMRI measurements of food-related inhibitory control: implications for BMI status and dietary intake. Neuroimage 2018;166:335-48.   DOI
9 Erhart M, Herpertz-Dahlmann B, Wille N, Sawitzky-Rose B, Holling H, Ravens-Sieberer U. Examining the relationship between attention-deficit/hyperactivity disorder and overweight in children and adolescents. Eur Child Adolesc Psychiatry 2012;21:39-49.   DOI
10 Deux N, Schlarb AA, Martin F, Holtmann M, Hebebrand J, Legenbauer T. Overweight in adolescent, psychiatric inpatients: a problem of general or food-specific impulsivity? Appetite 2017;112:157-66.   DOI
11 Joutsa J, Karlsson HK, Majuri J, Nuutila P, Helin S, Kaasinen V, et al. Binge eating disorder and morbid obesity are associated with lowered mu-opioid receptor availability in the brain. Psychiatry Res Neuroimaging 2018;276:41-5.   DOI
12 Val-Laillet D, Aarts E, Weber B, Ferrari M, Quaresima V, Stoeckel LE, et al. Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity. Neuroimage Clin 2015;8:1-31.   DOI
13 Polich J. Updating P300: an integrative theory of P3a and P3b. Clin Neurophysiol 2007;118:2128-48.   DOI
14 Klimesch W. Alpha-band oscillations, attention, and controlled access to stored information. Trends Cogn Sci 2012;16:606-17.   DOI
15 Klimesch W, Sauseng P, Hanslmayr S. EEG alpha oscillations: the inhibition-timing hypothesis. Brain Res Brain Res Rev 2007;53:63-88.   DOI
16 Luck SJ. An introduction to the event-related potential technique. 2nd ed. Cambridge (MA): MIT Press, 2014.
17 Gao H, Qi M, Zhang Q. Response inhibition is more effortful than response activation: behavioral and electrophysiological evidence. Neuroreport 2017;28:404-7.   DOI
18 Tascilar ME, Turkkahraman D, Oz O, Yucel M, Taskesen M, Eker I, et al. P300 auditory event-related potentials in children with obesity: is childhood obesity related to impairment in cognitive functions? Pediatr Diabetes 2011;12:589-95.   DOI
19 Reyes S, Peirano P, Peigneux P, Lozoff B, Algarin C. Inhibitory control in otherwise healthy overweight 10-year-old children. Int J Obes 2015;39:1230-5.   DOI
20 de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 2007;85:660-7.   DOI
21 Key AP, Dykens EM. 'Hungry Eyes': visual processing of food images in adults with Prader-Willi syndrome. J Intellect Disabil Res 2008;52:536-46.   DOI
22 Johnstone SJ, Barry RJ, Clarke AR. Ten years on: a follow-up review of ERP research in attention-deficit/hyperactivity disorder. Clin Neurophysiol 2013;124:644-57.   DOI
23 Chen L, Zhou Y, Liu L, Zhang X, Zhang H, Liu S. Cortical event-related potentials in Alzheimer's disease and frontotemporal lobar degeneration. J Neurol Sci 2015;359:88-93.   DOI
24 Duncan CC, Barry RJ, Connolly JF, Fischer C, Michie PT, Naatanen R, et al. Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. Clin Neurophysiol 2009;120:1883-908.   DOI
25 Tarantino V, Vindigni V, Bassetto F, Pavan C, Vallesi A. Behavioral and electrophysiological correlates of cognitive control in ex-obese adults. Biol Psychol 2017;127:198-208.   DOI
26 Onitsuka T, Oribe N, Nakamura I, Kanba S. Review of neurophysiological findings in patients with schizophrenia. Psychiatry Clin Neurosci 2013;67:461-70.   DOI
27 Kamijo K, Pontifex MB, Khan NA, Raine LB, Scudder MR, Drollette ES, et al. The association of childhood obesity to neuroelectric indices of inhibition. Psychophysiology 2012;49:1361-71.   DOI
28 Hume DJ, Howells FM, Rauch HG, Kroff J, Lambert EV. Electrophysiological indices of visual food cue-reactivity. Differences in obese, overweight and normal weight women. Appetite 2015;85:126-37.   DOI
29 Hoyniak C. Changes in the NoGo N2 event-related potential component across childhood: a systematic review and meta-analysis. Dev Neuropsychol 2017;42:1-24.   DOI
30 Tsai CL, Chen FC, Pan CY, Tseng YT. The neurocognitive performance of visuospatial attention in children with obesity. Front Psychol 2016;7:1033.
31 Nijs IM, Muris P, Euser AS, Franken IH. Differences in attention to food and food intake between overweight/obese and normal-weight females under conditions of hunger and satiety. Appetite 2010;54:243-54.   DOI