Browse > Article
http://dx.doi.org/10.5223/pghn.2017.20.3.167

Safety of a New Synbiotic Starter Formula  

Vandenplas, Yvan (Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel)
Analitis, Antonis (Department of Hygiene, Epidemiology and Medical Statistics, Faculty of Medicine, National and Kapodistrian University of Athens)
Tziouvara, Chara (3rd Pediatric Department, Hippocration Hospital)
Kountzoglou, Athina (3rd Pediatric Department, Hippocration Hospital)
Drakou, Anastasia (3rd Pediatric Department, Hippocration Hospital)
Tsouvalas, Manos (3rd Pediatric Department, Hippocration Hospital)
Mavroudi, Antigoni (3rd Pediatric Department, Hippocration Hospital)
Xinias, Ioannis (3rd Pediatric Department, Hippocration Hospital)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.20, no.3, 2017 , pp. 167-177 More about this Journal
Abstract
Purpose: Breastfeeding is the best way to feed all infants, but not all infants can be (exclusively) breastfed. Cow's milk based infant formula is the second choice infant feeding. Methods: The safety of a new synbiotic infant formula, supplemented with Bifidobacterium lactis and fructo-oligosaccharides, with lactose and a whey/casein 60/40 protein ratio was tested in 280 infants during 3 months. Results: The median age of the infants at inclusion was 0.89 months. Weight evolution was in accordance with the World Health Organization growth charts for exclusive breastfed infants. The evolution of all anthropometric parameters (weight-for-length z score and body mass index-for-age z score) was within the normal range. The incidence of functional constipation (3.2%), daily regurgitation (10.9%), infantile crying and colic (10.5%) were all significantly lower than the reported median prevalence for a similar age according to literature (median value of 7.8% for functional constipation, 26.7% for regurgitation, 17.7% for infantile colic). Conclusion: The new synbiotic infant starter formula was safe, resulted in normal growth and was well tolerated. Functional gastro-intestinal manifestations (functional constipation, regurgitation and colic) were significantly lower than reported in literature. Synbiotics (Bifidobacterium lactis and fructo-oligosaccharides) in cow's milk based infant formula bring the second choice infant feeding, formula, closer to the golden standard, exclusive breastfeeding.
Keywords
Functional gastrointestinal disorder; Growth; Infant formula; Prebiotics; Probiotics; Synbiotics;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Braegger C, Chmielewska A, Decsi T, Kolacek S, Mihatsch W, Moreno L, et al; ESPGHAN Committee on Nutrition. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr 2011;52:238-50.   DOI
2 Huet F, Abrahamse-Berkeveld M, Tims S, Simeoni U, Beley G, Savagner C, et al. Partly fermented infant formulae with specific oligosaccharides support adequate infant growth and are well-tolerated. J Pediatr Gastroenterol Nutr 2016;63:e43-53.   DOI
3 Weaver LT, Ewing G, Taylor LC. The bowel habit of milk-fed infants. J Pediatr Gastroenterol Nutr 1988; 7:568-71.   DOI
4 Bocquet A, Lachambre E, Kempf C, Beck L. Effect of infant and follow-on formulas containing B lactis and galacto-and fructo-oligosaccharides on infection in healthy term infants. J Pediatr Gastroenterol Nutr 2013; 57:180-7.   DOI
5 Vandenplas Y, De Greef E, Veereman G. Prebiotics in infant formula. Gut Microbes 2014;5:681-7.   DOI
6 Holscher HD, Czerkies LA, Cekola P, Litov R, Benbow M, Santema S, et al. Bifidobacterium lactis Bb12 enhances intestinal antibody response in formula-fed infants: a randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr 2012;36(1 Suppl): 106S-17S.   DOI
7 Indrio F, Di Mauro A, Riezzo G, Civardi E, Intini C, Corvaglia L, et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr 2014;168:228-33.   DOI
8 Vandenplas Y, Abkari A, Bellaiche M, Benninga M, Chouraqui JP, Cokura F, et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr 2015;61:531-7.   DOI
9 Ben XM, Li J, Feng ZT, Shi SY, Lu YD, Chen R, et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol 2008;14:6564-8.   DOI
10 Veereman-Wauters G, Staelens S, Van de Broek H, Plaskie K, Wesling F, Roger LC, et al. Physiological and bifidogenic effects of prebiotic supplements in infant formulae. J Pediatr Gastroenterol Nutr 2011;52:763-71.   DOI
11 Scholtens PA, Alliet P, Raes M, Alles MS, Kroes H, Boehm G, et al. Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides. J Nutr 2008;138:1141-7.   DOI
12 Iacono G, Merolla R, D'Amico D, Bonci E, Cavataio F, Di Prima L, et al; Paediatric Study Group on Gastrointestinal Symptoms in Infancy. Gastrointestinal symptoms in infancy: a population-based prospective study. Dig Liver Dis 2005;37:432-8.   DOI
13 Giovannini M, Verduci E, Gregori D, Ballali S, Soldi S, Ghisleni D, et al; PLAGOS Trial Study Group. Prebiotic effect of an infant formula supplemented with galacto- oligosaccharides: randomized multicenter trial. J Am Coll Nutr 2014;33:385-93.   DOI
14 Savino F, Palumeri E, Castagno E, Cresi F, Dalmasso P, Cavallo F, et al. Reduction of crying episodes owing to infantile colic: a randomized controlled study on the efficacy of a new infant formula. Eur J Clin Nutr 2006;60:1304-10.   DOI
15 Gerasimov SV, Vasjuta VV, Myhovych OO, Bondarchuk LI. Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial. Am J Clin Dermatol 2010;11:351-61.   DOI
16 Kapiki A, Costalos C, Oikonomidou C, Triantafyllidou A, Loukatou E, Pertrohilou V. The effect of a fructo-oligosaccharide supplemented formula on gut flora of preterm infants. Early Hum Dev 2007;83:335-9.   DOI
17 Savino F, Maccario S, Castagno E, Cresi F, Cavallo F, Dalmasso P, et al. Advances in the management of digestive problems during the first months of life. Acta Paediatr Suppl 2005;94:120-4.   DOI
18 Field CJ. The immunological components of human milk and their effect on immune development in infants. J Nutr 2005;135:1-4.   DOI
19 Jost T, Lacroix C, Braegger C, Chassard C. Impact of human milk bacteria and oligosaccharides on neonatal gut microbiota establishment and gut health. Nutr Rev 2015;73:426-37.   DOI
20 Wopereis H, Oozeer R, Knipping K, Belzer C, Knol J. The first thousand days-intestinal microbiology of early life: establishing a symbiosis. Pediatr Allergy Immunol 2014;25:428-38.   DOI
21 Backhed F, Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva-Datchary P, et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 2015;17:690-703.   DOI
22 Reisinger KW, de Vaan L, Kramer BW, Wolfs TG, van Heurn LW, Derikx JP. Breast-feeding improves gut maturation compared with formula feeding in preterm babies. J Pediatr Gastroenterol Nutr 2014;59:720-4.   DOI
23 Vandenplas Y, Zakharova I, Dmitrieva Y. Oligosaccharides in infant formula: more evidence to validate the role of prebiotics. Br J Nutr 2015;113:1339-44.   DOI
24 Szajewska H, Chmielewska A. Growth of infants fed formula supplemented with Bifidobacterium lactis Bb12 or Lactobacillus GG: a systematic review of randomized controlled trials. BMC Pediatr 2013;13:185.   DOI
25 Steenhout PG, Rochat F, Hager C. The effect of Bifidobacterium lactis on the growth of infants: a pooled analysis of randomized controlled studies. Ann Nutr Metab 2009;55:334-40.   DOI
26 Garcia C, Duan RD, Brevaut-Malaty V, Gire C, Millet V, Simeoni U, et al. Bioactive compounds in human milk and intestinal health and maturity in preterm newborn: an overview. Cell Mol Biol (Noisy-le-grand) 2013; 59:108-31.