Browse > Article
http://dx.doi.org/10.5223/pghn.2017.20.2.130

Ileal Perforation with Norovirus Gastroenteritis in a 3-Month-Old Infant  

Wi, Seol Woo (Department of Pediatrics, Dongguk University Ilsan Hospital)
Lee, Su Jin (Department of Pediatrics, Dongguk University Ilsan Hospital)
Kang, Eun Kyeong (Department of Pediatrics, Dongguk University Ilsan Hospital)
Cho, Sung Min (Department of Pediatrics, Dongguk University Ilsan Hospital)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.20, no.2, 2017 , pp. 130-133 More about this Journal
Abstract
Noroviruses have been recognized as the leading cause of epidemic and sporadic gastroenteritis since the advent of molecular diagnostic technique. They have been documented in 5-31% of pediatric patients hospitalized with gastroenteritis. Although norovirus gastroenteritis is typically mild and self-limited, it causes severe, but sometimes fatal, conditions in the vulnerable population such as immunocompromised patients, young children, and the elderly. Bowel perforation due to norovirus infection is rare. We report a case of small bowel perforation with norovirus gastroenteritis in the infant with Down syndrome during the hospitalization with pneumonia. Severe dehydration may cause bowel ischemia and could have triggered bowel perforation in this case. Physicians should be alert to the potential surgical complications followed by severe acute diarrhea, especially in high risk groups.
Keywords
Norovirus; Gastroenteritis; Child;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Glass RI, Parashar UD, Estes MK. Norovirus gastroenteritis. N Engl J Med 2009;361:1776-85.   DOI
2 Matthews JE, Dickey BW, Miller RD, Felzer JR, Dawson BP, Lee AS, et al. The epidemiology of published norovirus outbreaks: a review of risk factors associated with attack rate and genogroup. Epidemiol Infect 2012;140:1161-72.   DOI
3 Mattner F, Sohr D, Heim A, Gastmeier P, Vennema H, Koopmans M. Risk groups for clinical complications of norovirus infections: an outbreak investigation. Clin Microbiol Infect 2006;12:69-74.   DOI
4 Patel MM, Widdowson MA, Glass RI, Akazawa K, Vinje J, Parashar UD. Systematic literature review of role of noroviruses in sporadic gastroenteritis. Emerg Infect Dis 2008;14:1224-31.   DOI
5 Bull RA, Tu ET, McIver CJ, Rawlinson WD, White PA. Emergence of a new norovirus genotype II.4 variant associated with global outbreaks of gastroenteritis. J Clin Microbiol 2006;44:327-33.   DOI
6 Mans J, de Villiers JC, du Plessis NM, Avenant T, Taylor MB. Emerging norovirus GII.4 2008 variant detected in hospitalised paediatric patients in South Africa. J Clin Virol 2010;49:258-64.   DOI
7 Johnston CP, Qiu H, Ticehurst JR, Dickson C, Rosenbaum P, Lawson P, et al. Outbreak management and implications of a nosocomial norovirus outbreak. Clin Infect Dis 2007;45:534-40.   DOI
8 Beersma MF, Schutten M, Vennema H, Hartwig NG, Mes TH, Osterhaus AD, et al. Norovirus in a Dutch tertiary care hospital (2002-2007): frequent nosocomial transmission and dominance of GIIb strains in young children. J Hosp Infect 2009;71:199-205.   DOI
9 Beersma MF, Sukhrie FH, Bogerman J, Verhoef L, Mde Melo M, Vonk AG, et al. Unrecognized norovirus infections in health care institutions and their clinical impact. J Clin Microbiol 2012;50:3040-5.   DOI
10 Pawa N, Vanezis AP, Tutton MG. Spontaneous bowel perforation due to norovirus: a case report. Cases J 2009;2:9101.   DOI
11 Souza M, Azevedo MS, Jung K, Cheetham S, Saif LJ. Pathogenesis and immune responses in gnotobiotic calves after infection with the genogroup II.4-HS66 strain of human norovirus. J Virol 2008;82:1777-86.   DOI
12 Pelizzo G, Nakib G, Goruppi I, Fusillo M, Scorletti F, Mencherini S, et al. Isolated colon ischemia with norovirus infection in preterm babies: a case series. J Med Case Rep 2013;7:108.   DOI
13 Turcios-Ruiz RM, Axelrod P, St John K, Bullitt E, Donahue J, Robinson N, et al. Outbreak of necrotizing enterocolitis caused by norovirus in a neonatal intensive care unit. J Pediatr 2008;153:339-44.   DOI
14 Ueda N, Shimotake T, Ohama K. Duodenal perforation associated with norovirus and rotavirus gastroenteritis. Clin Case Rep 2013;1:47-9.   DOI
15 Chen JC, Chen CC, Liang JT. Huang SF. Spontaneous bowel perforation in infants and young children: a clinicopathologic analysis of pathogenesis. J Pediatr Gastroenterol Nutr 2000;30:432-5.   DOI
16 Ballance WA, Dahms BB, Shenker N, Kliegman RM. Pathology of neonatal necrotizing enterocolitis: a ten-year experience. J Pediatr 1990;117:S6-13.   DOI
17 Kusters MA, Verstegen RH, Gemen EF, de Vries E. Intrinsic defect of the immune system in children with Down syndrome: a review. Clin Exp Immunol 2009;156:189-93.   DOI
18 Verstegen RH, Kusters MA, Gemen EF, DE Vries E. Down syndrome B-lymphocyte subpopulations, intrinsic defect or decreased T-lymphocyte help. Pediatr Res 2010;67:563-9.   DOI