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http://dx.doi.org/10.5223/pghn.2017.20.1.1

The New Rome IV Criteria for Functional Gastrointestinal Disorders in Infants and Toddlers  

Zeevenhooven, Judith (Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Center)
Koppen, Ilan J.N. (Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Center)
Benninga, Marc A. (Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Center)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.20, no.1, 2017 , pp. 1-13 More about this Journal
Abstract
Functional gastrointestinal disorders (FGIDs) are common worldwide and cover a wide range of disorders attributable to the gastrointestinal tract that cannot be explained by structural or biochemical abnormalities. The diagnosis of these disorders relies on the symptom-based Rome criteria. In 2016 the Rome criteria were revised for infants/toddlers and for children and adolescents. In this review, we discuss the novel Rome IV criteria for infants and toddlers. The criteria for infant colic were drastically changed, whereas only minor changes were made for regurgitation, cyclic vomiting syndrome, functional diarrhea, infant dyschezia and functional constipation. In addition to this, the new Rome IV discusses underlying mechanisms of pain in infants and toddlers, including the neurodevelopment of nociceptive and pain pathways, the various factors that are involved in pain experience, and methods of pain assessment in infants and toddlers is essential for the clinician who encounters functional pain in this age group. Overall, the Rome IV criteria have become more distinctive for all disorders in order to improve the process of diagnosing pediatric FGIDs.
Keywords
Functional gastrointestinal disorders; Infant; Toddlers;
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1 Milidou I, Sondergaard C, Jensen MS, Olsen J, Henriksen TB. Gestational age, small for gestational age, and infantile colic. Paediatr Perinat Epidemiol 2014;28:138-45.   DOI
2 Douglas P, Hill P. Managing infants who cry excessively in the first few months of life. BMJ 2011;343:d7772.   DOI
3 Talge NM, Neal C, Glover V; Early Stress, Translational Research and Prevention Science Network: Fetal and Neonatal Experience on Child and Adolescent Mental Health. Antenatal maternal stress and longterm effects on child neurodevelopment: how and why? J Child Psychol Psychiatry 2007;48:245-61.   DOI
4 van den Berg MP, van der Ende J, Crijnen AA, Jaddoe VW, Moll HA, Mackenbach JP, et al. Paternal depressive symptoms during pregnancy are related to excessive infant crying. Pediatrics 2009;124:e96-103.   DOI
5 Indrio F, Riezzo G, Raimondi F, Di Mauro A, Francavilla R. Gut motility alterations in neonates and young infants. J Pediatr Gastroenterol Nutr 2013;57:S9-11.   DOI
6 Gupta SK. Is colic a gastrointestinal disorder? Curr Opin Pediatr 2002;14:588-92.   DOI
7 Rhoads JM, Fatheree NY, Norori J, Liu Y, Lucke JF, Tyson JE, et al. Altered fecal microflora and increased fecal calprotectin in infants with colic. J Pediatr 2009;155:823-8.e1.   DOI
8 de Weerth C, Fuentes S, Puylaert P, de Vos WM. Intestinal microbiota of infants with colic: development and specific signatures. Pediatrics 2013;131:e550-8.   DOI
9 Nooitgedagt JE, Zwart P, Brand PL. Causes, treatment and clinical outcome in infants admitted because of excessive crying to the paediatric department of the Isala clinics, Zwolle, the Netherlands, 1997/'03. Ned Tijdschr Geneeskd 2005;149:472-7.
10 Lucassen PL, Assendelft WJ, Gubbels JW, van Eijk JT, van Geldrop WJ, Neven AK. Effectiveness of treatments for infantile colic: systematic review. BMJ 1998;316:1563-9.   DOI
11 Barr RG. The normal crying curve: what do we really know? Dev Med Child Neurol 1990;32:356-62.
12 Freedman SB, Al-Harthy N, Thull-Freedman J. The crying infant: diagnostic testing and frequency of serious underlying disease. Pediatrics 2009;123:841-8.   DOI
13 Fujiwara T, Barr RG, Brant R, Barr M. Infant distress at five weeks of age and caregiver frustration. J Pediatr 2011;159:425-30.e1-2.   DOI
14 Shamir R, St James-Roberts I, Di Lorenzo C, Burns AJ, Thapar N, Indrio F, et al. Infant crying, colic, and gastrointestinal discomfort in early childhood: a review of the evidence and most plausible mechanisms. J Pediatr Gastroenterol Nutr 2013;57 Suppl 1:S1-45.
15 Wessel MA, Cobb JC, Jackson EB, Harris GS Jr, Detwiler AC. Paroxysmal fussing in infancy, sometimes called colic. Pediatrics 1954;14:421-35.
16 Barr RG. Excessive crying. In: Sameroff AJ, Lewis M, Miller SM, eds. Handbook of developmental psychopathology. 2nd ed. New York: Kluwer Academic/Plenum Publishers, 2000:327-50.
17 Gustafson G, Wood R, Green J. Can we hear the causes of infants' crying? In: Barr RG, Hopkins B, Green JA, eds. Crying as a sign, a symptom, and a signal. London: Mac Keith Press, 2000:8-22.
18 James-Roberts IS, Conroy S, Wilsher K. Bases for maternal perceptions of infant crying and colic behaviour. Arch Dis Child 1996;75:375-84.   DOI
19 Meyer EC, Coll CT, Lester BM, Boukydis CF, McDonough SM, Oh W. Family-based intervention improves maternal psychological well-being and feeding interaction of preterm infants. Pediatrics 1994;93:241-6.
20 Benninga MA, Faure C, Hyman PE, St James Roberts I, Schechter NL, Nurko S. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology 2016;150:1443-55.e2.   DOI
21 Drossman DA. Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV. Gastroenterology 2016;150:1262-79.e2.   DOI
22 Ferreira-Maia AP, Matijasevich A, Wang YP. Epidemiology of functional gastrointestinal disorders in infants and toddlers: a systematic review. World J Gastroenterol 2016;22:6547-58.   DOI
23 Vik T, Grote V, Escribano J, Socha J, Verduci E, Fritsch M, et al. Infantile colic, prolonged crying and maternal postnatal depression. Acta Paediatr 2009;98:1344-8.   DOI
24 Kurth E, Kennedy HP, Spichiger E, Hosli I, Stutz EZ. Crying babies, tired mothers: what do we know? A systematic review. Midwifery 2011;27:187-94.   DOI
25 Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006;130:1377-90.   DOI
26 Hyman PE, Milla PJ, Benninga MA, Davidson GP, Fleisher DF, Taminiau J. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology 2006;130:1519-26.   DOI
27 Rasquin A, Di Lorenzo C, Forbes D, Guiraldes E, Hyams JS, Staiano A, et al. Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology 2006;130:1527-37.   DOI
28 van Tilburg MA, Hyman PE, Walker L, Rouster A, Palsson OS, Kim SM, et al. Prevalence of functional gastrointestinal disorders in infants and toddlers. J Pediatr 2015;166:684-9.   DOI
29 Chogle A, Velasco-Benitez CA, Koppen IJ, Moreno JE, Ramirez Hernandez CR, Saps M. A population-based study on the epidemiology of functional gastrointestinal disorders in young children. J Pediatr 2016;179:139-43.e1.   DOI
30 Osatakul S, Sriplung H, Puetpaiboon A, Junjana CO, Chamnongpakdi S. Prevalence and natural course of gastroesophageal reflux symptoms: a 1-year cohort study in Thai infants. J Pediatr Gastroenterol Nutr 2002;34:63-7.   DOI
31 Nelson SP, Chen EH, Syniar GM, Christoffel KK. Prevalence of symptoms of gastroesophageal reflux during infancy. A pediatric practice-based survey. Pediatric Practice Research Group. Arch Pediatr Adolesc Med 1997;151:569-72.   DOI
32 Rasquin-Weber A, Hyman PE, Cucchiara S, Fleisher DR, Hyams JS, Milla PJ, et al. Childhood functional gastrointestinal disorders. Gut 1999;45 Suppl 2:II60-8.
33 Sung V, Hiscock H, Tang ML, Mensah FK, Nation ML, Satzke C, et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ 2014;348:g2107.   DOI
34 Murray L, Cooper P. The impact of irritable infant behavior on maternal mental state: a longitudinal study and a treatment trial. In: Barr RG, St James-Roberts I, Keefe MR, eds. New evidence on unexplained early infant crying: its origins, nature and management. Skillman, NJ: Johnson & Johnson Pediatric Institute, 2001:149-64.
35 Savino F, Cordisco L, Tarasco V, Palumeri E, Calabrese R, Oggero R, et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo- controlled trial. Pediatrics 2010;126:e526-33.   DOI
36 Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trial. J Pediatr 2013;162:257-62.   DOI
37 Sung V, Collett S, de Gooyer T, Hiscock H, Tang M, Wake M. Probiotics to prevent or treat excessive infant crying: systematic review and meta-analysis. JAMA Pediatr 2013;167:1150-7.   DOI
38 Kramer EA, den Hertog-Kuijl JH, van den Broek LM, van Leengoed E, Bulk AM, Kneepkens CM, et al. Defecation patterns in infants: a prospective cohort study. Arch Dis Child 2015;100:533-6.   DOI
39 Malowitz S, Green M, Karpinski A, Rosenberg A, Hyman PE. Age of onset of functional constipation. J Pediatr Gastroenterol Nutr 2016;62:600-2.   DOI
40 Vandenplas Y, Abkari A, Bellaiche M, Benninga M, Chouraqui JP, Cokura F, et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr 2015;61:531-7.   DOI
41 Vandenplas Y, Rudolph CD, Di Lorenzo C, Hassall E, Liptak G, Mazur L, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr 2009;49:498-547.   DOI
42 Horvath A, Dziechciarz P, Szajewska H. The effect of thickened-feed interventions on gastroesophageal reflux in infants: systematic review and meta-analysis of randomized, controlled trials. Pediatrics 2008;122:e1268-77.   DOI
43 Vandenplas Y, Leluyer B, Cazaubiel M, Housez B, Bocquet A. Double-blind comparative trial with 2 antiregurgitation formulae. J Pediatr Gastroenterol Nutr 2013;57:389-93.   DOI
44 van Wijk MP, Benninga MA, Davidson GP, Haslam R, Omari TI. Small volumes of feed can trigger transient lower esophageal sphincter relaxation and gastroesophageal reflux in the right lateral position in infants. J Pediatr 2010;156:744-8, 748.e1.   DOI
45 Task Force on Sudden Infant Death Syndrome, Moon RY. SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment. Pediatrics 2011;128:e1341-67.   DOI
46 Fleisher DR. Infant rumination syndrome: report of a case and review of the literature. Am J Dis Child 1979;133:266-9.   DOI
47 Fleisher DR, Matar M. The cyclic vomiting syndrome: a report of 71 cases and literature review. J Pediatr Gastroenterol Nutr 1993;17:361-9.   DOI
48 Headache Classification Committee of the International Headache Society (IHS). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 2013;33:629-808.   DOI
49 Koppen IJ, Lammers LA, Benninga MA, Tabbers MM. Management of functional constipation in children: therapy in practice. Paediatr Drugs 2015;17:349-60.   DOI
50 Li BU, Lefevre F, Chelimsky GG, Boles RG, Nelson SP, Lewis DW, et al. North american society for pediatric gastroenterology, hepatology, and nutrition consensus statement on the diagnosis and management of cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr 2008;47:379-93.   DOI
51 Saps M, Adams P, Bonilla S, Chogle A, Nichols-Vinueza D. Parental report of abdominal pain and abdominal pain-related functional gastrointestinal disorders from a community survey. J Pediatr Gastroenterol Nutr 2012;55:707-10.   DOI
52 Saps M, Nichols-Vinueza DX, Rosen JM, Velasco-Benitez CA. Prevalence of functional gastrointestinal disorders in Colombian school children. J Pediatr 2014;164:542-5.e1.   DOI
53 Devanarayana NM, Adhikari C, Pannala W, Rajindrajith S. Prevalence of functional gastrointestinal diseases in a cohort of Sri Lankan adolescents: comparison between Rome II and Rome III criteria. J Trop Pediatr 2011;57:34-9.   DOI
54 Lewis ML, Palsson OS, Whitehead WE, van Tilburg MA. Prevalence of functional gastrointestinal disorders in children and adolescents. J Pediatr 2016;177:39-43.e3.   DOI
55 Steutel NF, Benninga MA, Langendam MW, de Kruijff I, Tabbers MM. Reporting outcome measures in trials of infant colic. J Pediatr Gastroenterol Nutr 2014;59:341-6.   DOI
56 Lucassen PL, Assendelft WJ, van Eijk JT, Gubbels JW, Douwes AC, van Geldrop WJ. Systematic review of the occurrence of infantile colic in the community. Arch Dis Child 2001;84:398-403.   DOI
57 Fitzgerald M. The development of nociceptive circuits. Nat Rev Neurosci 2005;6:507-20.
58 Tabbers MM, DiLorenzo C, Berger MY, Faure C, Langendam MW, Nurko S, et al. Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J Pediatr Gastroenterol Nutr 2014;58:258-74.
59 von Baeyer CL, Champion GD. Commentary: multiple pains as functional pain syndromes. J Pediatr Psychol 2011;36:433-7.   DOI
60 Lee SJ, Ralston HJ, Drey EA, Partridge JC, Rosen MA. Fetal pain: a systematic multidisciplinary review of the evidence. JAMA 2005;294:947-54.   DOI
61 Lowery CL, Hardman MP, Manning N, Hall RW, Anand KJ, Clancy B. Neurodevelopmental changes of fetal pain. Semin Perinatol 2007;31:275-82.   DOI
62 Fitzgerald M, Walker SM. Infant pain management: a developmental neurobiological approach. Nat Clin Pract Neurol 2009;5:35-50.
63 Chitkara DK, van Tilburg MA, Blois-Martin N, Whitehead WE. Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review. Am J Gastroenterol 2008;103:765-74; quiz 775.   DOI
64 Gebhart GF. Pathobiology of visceral pain: molecular mechanisms and therapeutic implications IV. Visceral afferent contributions to the pathobiology of visceral pain. Am J Physiol Gastrointest Liver Physiol 2000;278:G834-8.   DOI
65 Hjermstad MJ, Fayers PM, Haugen DF, Caraceni A, Hanks GW, Loge JH, et al. Studies comparing numerical rating scales, verbal rating scales, and visual analogue scales for assessment of pain intensity in adults: a systematic literature review. J Pain Symptom Manage 2011;41:1073-93.   DOI
66 Barr RG, St. James-Roberts I, Keefe MR. New evidence on unexplained early infant crying: its origins, nature and management. Skillman, NJ: Johnson & Johnson Pediatric Institute, 2001.
67 James-Roberts IS, Conroy S, Wilsher K. Clinical, developmental and social aspects of infant crying and colic. Infant Child Dev 1995;4:177-89.
68 Rautava P, Helenius H, Lehtonen L. Psychosocial predisposing factors for infantile colic. BMJ 1993;307:600-4.   DOI
69 Wolke D. Behavioural treatment of prolonged infant crying: evaluation, methods, and a proposal. In: Barr RG, St James-Roberts I, Keefe MR, eds. New evidence on unexplained early infant crying: its origins, nature and management. Skillman, NJ: Johnson & Johnson Pediatric Institute, 2001:187-208.
70 Treem WR. Infant colic. A pediatric gastroenterologist's perspective. Pediatr Clin North Am 1994;41:1121-38.   DOI
71 Treem WR. Assessing crying complaints: the interaction with gastroesophageal reflux and cow's milk protein intolerance. In: New evidence on unexplained early infant crying: its origins, nature and management. Skillman, NJ: Johnson & Johnson Pediatric Institute, 2001:165-76.
72 Shamir R. Infant colic and functional gastrointestinal disorders: is there more than a "gut feeling"? J Pediatr Gastroenterol Nutr 2013;57:S1-2.
73 Barr RG, Young SN, Wright JH, Gravel R, Alkawaf R. Differential calming responses to sucrose taste in crying infants with and without colic. Pediatrics 1999;103:e68.   DOI
74 Lester BM, Boukydis CZ, Garcia-Coll CT, Hole WT. Colic for developmentalists. Infant Ment Health J 1990;11:321-33.   DOI
75 Slater R, Cantarella A, Gallella S, Worley A, Boyd S, Meek J, et al. Cortical pain responses in human infants. J Neurosci 2006;26:3662-6.   DOI
76 DeSantis A, Coster W, Bigsby R, Lester B. Colic and fussing in infancy, and sensory processing at 3 to 8 years of age. Infant Ment Health J 2004;25:522-39.   DOI
77 St James-Roberts I, Halil T. Infant crying patterns in the first year: normal community and clinical findings. J Child Psychol Psychiatry 1991;32:951-68.   DOI
78 Tomlinson D, von Baeyer CL, Stinson JN, Sung L. A systematic review of faces scales for the self-report of pain intensity in children. Pediatrics 2010;126:e1168-98.   DOI