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http://dx.doi.org/10.5223/pghn.2015.18.2.144

Atypical β-Catenin Activated Child Hepatocellular Tumor  

Turan, Aynur (Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital)
Unlu, Havva Akmaz (Department of Radiology, Ankara Pediatric Hematology and Oncology Training and Research Hospital)
Karakus, Esra (Department of Patology, Ankara Pediatric Hematology and Oncology Training and Research Hospital)
Erdem, Arzu Yazal (Department of Pediatrics, Ankara Pediatric Hematology and Oncology Training and Research Hospital)
Yakut, Zeynep Ilerisoy (Department of Radiology, Ankara Ataturk Training and Research Hospital)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.18, no.2, 2015 , pp. 144-148 More about this Journal
Abstract
Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features. The ${\beta}$-catenin activated subtype accounts for 10-15% of all hepatocellular adenomas and specific magnetic resonance imaging features have been defined for different hepatocellular adenomas subtypes. The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of ${\beta}$-catenin activated hepatocellular adenomas in a child. In this case, atypical diffuse steatosis was determined in the lesion. In the literature, diffuse steatosis, which is defined as a feature of the hepatocyte nuclear factor-$1{\alpha}$-inactivated hepatocellular adenomas subtype, has not been previously reported in any ${\beta}$-catenin activated hepatocellular adenomas case. Interlacing magnetic resonance imaging findings between subtypes show that there are still many mysteries about this topic and larger studies are warranted.
Keywords
Adenoma; Liver; Hepatocellular carcinoma; Magnetic resonance imaging; Beta-catenin;
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