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http://dx.doi.org/10.5223/pghn.2015.18.1.10

Changing Prevalence of Helicobacter pylori Infections in Korean Children with Recurrent Abdominal Pain  

Jang, Kyung Mi (Department of Pediatrics, Kyungpook National University School of Medicine)
Choe, Byung-Ho (Department of Pediatrics, Kyungpook National University School of Medicine)
Choe, Jae Young (Department of Pediatrics, Kyungpook National University School of Medicine)
Hong, Suk Jin (Department of Pediatrics, Kyungpook National University School of Medicine)
Park, Hyo Jung (Department of Pediatrics, Kyungpook National University School of Medicine)
Chu, Mi Ae (Department of Pediatrics, Kyungpook National University School of Medicine)
Cho, Seung Man (Department of Pediatrics, Kyungpook National University School of Medicine)
Kim, Jung Mi (Department of Pediatrics, Kyungpook National University School of Medicine)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.18, no.1, 2015 , pp. 10-16 More about this Journal
Abstract
Purpose: The aim of this study is to investigate the changing prevalence rate of Helicobacter pylori infection in children, of different age groups, with recurrent abdominal pain over a 10-year period. Methods: Children with recurrent abdominal pain who visited the pediatric outpatient clinic at university hospital were screened for H. pylori. Children were divided into 3 age categories of 4-5, 6-11, and 12-16 years. To study the changes in the annual prevalence rates of H. pylori infection, the study period was divided into 3 time periods: 2004-2007, 2008-2010, and 2011-2014. Urea breath test was performed for all children aged 4-16 years, with a cut-off value of 4.0‰ for children aged ${\geq}6$ years and 7‰ for children aged <6 years. Results: A total of 2,530 children (1,191 boys) with a mean age of $10.0{\pm}3.0years$ (range, 4.0-16.9 years) were included in the study. The total prevalence of H. pylori infection was 7.4% (187/2,530). The prevalence rate of H. pylori infection in children with recurrent abdominal pain was 8.0% (70/873) in 2004-2007, 7.7% (51/666) in 2008-2010, and 6.7% (66/991) in the 2011-2014. Nevertheless, a significant difference was observed in the prevalence rate between children <12 years old and ${\geq}12$ years of age (p=0.018). Conclusion: The prevalence of H. pylori infection in Korean children with recurrent abdominal pain was 7.4%, showing no significant decrease in the last 11 years; however, the prevalence rate in children <12 years old was significantly lower than that in those ${\geq}12$ years old.
Keywords
Helicobacter; Functional gastrointestinal disorder; Breath test; Endoscopy; Child;
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