Browse > Article

Cytologic Findings of Fine Needle Aspiration Biopsy of 23 Schwannomas  

Chang, Sun-Hee (Department of Pathology, InJe University Ilsan Paik Hospital)
Joo, Mee (Department of Pathology, InJe University Ilsan Paik Hospital)
Kim, Han-Seong (Department of Pathology, InJe University Ilsan Paik Hospital)
Publication Information
The Korean Journal of Cytopathology / v.19, no.1, 2008 , pp. 41-46 More about this Journal
Abstract
In an attempt to better define the cytologic characteristics of schwannomas, we have reviewed aspirates and corresponding histologic sections from 23 schwannomas. Of this number, the original cytologic diagnoses were: schwannoma in 14 cases (61%), benign soft tissue tumor in 2 cases (9%), and insufficient specimen in 7 cases (30%). The cytologic findings common to all cases of schwannoma included fragments of tightly cohesive fascicles with variable cellularity and corresponding Antoni type A area. The Antoni type B area, consisting of scattered spindle cells and some histiocytes and lymphocytes against a myxoid background, was seen in 14 cases. Fibrillary stroma was seen in 12 cases. The tumor cells had spindle- or ovalshaped nuclei, with pointed ends and indistinct cell borders. Nuclear palisading was seen in 10 cases, and distinctive Verocay bodies were seen in 5 cases. In ancient schwannomas, there were no Verocay bodies. Most schwannomas have distinct cytomorphologic features that allow correct diagnosis. The major problem with fine needle aspiration cytology of these tumors is the high frequency of poor cellularity, particularly in lesions with cystic degeneration. Of 7 cases with insufficient specimen, 4 showed marked cystic changes and 1 showed marked hyaline changes on histologic sections. In conclusion, we believe that if cytopathologist reminds the situation such as cystic degeneration or hyaline degeneration, the correct diagnosis of the schwannoma will be easily made.
Keywords
Schwannoma; Fine needle aspiration cytology;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Kim SY, Nam HJ, Kim JH, Cho YR, Kang YN, Lee SS. Fine needle aspiration cytologic features of schwannomas. Korean J Cytopathol 1999;10:55-60
2 Mooney EE, Layfield LJ, Dodd LG. Fine-needle aspiration of neural lesions. Diagn cytopathol 1999;20:1-5   DOI   ScienceOn
3 Gray W, Mckee GT. Diagnostic Cytopathology. 2nd ed. Edinburgh: Churchill Livingstone, 2003; 894
4 Dodd LG, Martinez S. Fine-needle aspiration cytology of pseudosarcomatous lesions of soft tissue. Diagn Cytopathol. 2001;24:28-35   DOI   ScienceOn
5 Klijanienko J, Caillaud JM, Lagace R, Vielh P. Fine-needle aspiration of leiomyosarcoma: a correlative cytohistopathological study of 96 tumors in 68 patients. Diagn Cytopathol 2003;28:119-25   DOI   ScienceOn
6 Yu GH, Sack MJ, Baloch Z, Gupta PK. Difficulties in the fine needle aspiration (FNA) diagnosis of schwannoma. Cytopathology 1999;10:186-94   DOI   ScienceOn
7 Dodd LG, Marom EM, Dash RC, Matthews MR, McLendon RE. Fine-needle aspiration cytology of "ancient" schwannoma. Diagn Cytopathol 1999;20:307-11   DOI   ScienceOn
8 Joo HJ, Lee KG. Cytologic findings of fine needle aspiration biopsy of ancient schwannoma. Korean J Cytopathol 1990;1:158-63   과학기술학회마을
9 Kong CS, Cha I. Nodular fasciitis: diagnosis by fine needle aspiration biopsy. Acta Cytol 2004;48:473-7   DOI   ScienceOn
10 Maitra A, Ashfaq R, Saboorian MH, Lindberg G, Gokaslan ST. The role of fine-needle aspiration biopsy in the primary diagnosis of mesenchymal lesions: a community hospital- based experience. Cancer 2000;90:178-85   DOI
11 Klijanienko J, Caillaud JM, Lagace R, Vielh P. Cytohistologic correlations in 56 synovial sarcomas in 36 patients: the Institut Curie experience. Diagn Cytopathol 2002;27:96-102   DOI   ScienceOn
12 Klijanienko J, Caillaud JM, Lagace R. Cytohistologic correlations in schwannomas (neurilemmomas), including "ancient," cellular, and epithelioid variants. Diagn Cytopathol 2006;34:517-22   DOI   ScienceOn
13 Domanski HA, Akerman M, Engellau J, Gustafson P, Mertens F, Rydholm A. Fine-needle aspiration of neurilemoma (schwannoma). A clinicocytopathologic study of 116 patients. Diagn cytopathol 2006;34:403-12   DOI   ScienceOn
14 Owens CL, Sharma R, Ali SZ. Deep fibromatosis (desmoid tumor): cytopathologic characteristics, clinicoradiologic features, and immunohistochemical findings on fine-needle aspiration. Cancer 2007;111:166-72   DOI   ScienceOn
15 Resnick JM, Fanning CV, Caraway NP, Varma DG, Johnson M. Percutaneous needle biopsy diagnosis of benign neurogenic neoplasms. Diagn Cytopathol 1997;16:17-25   DOI   ScienceOn
16 Domanski HA, Carlen B, Jonsson K, Mertens F, Akerman M. Distinct cytologic features of spindle cell lipoma. A cytologic-histologic study with clinical, radiologic, electronmicroscopic, and cytogenetic correlations. Cancer 2001;93:381-9   DOI
17 Akerman M, Ryd W, Skytting B, Scandinavian Sarcoma G. Fine-needle aspiration of synovial sarcoma: criteria for diagnosis: retrospective reexamination of 37 cases, including ancillary diagnostics. A Scandinavian Sarcoma Group study. Diagn Cytopathol 2003;28:232-8   DOI   ScienceOn