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Cytologic Features of Secretory Meningioma in Squash Preparation -A Case Report-  

Kim, Se-Hoon (Department of Pathology, College of Medicine, Yonsei University)
Lee, Kwang-Gil (Department of Pathology, Wonju College of Medicine, Yonsei University)
Kim, Tai-Seung (Department of Pathology, College of Medicine, Yonsei University)
Publication Information
The Korean Journal of Cytopathology / v.15, no.1, 2004 , pp. 52-55 More about this Journal
Abstract
Secretory meningioma is a distinct subtype of meningioma. We describe the cytologic features of a secretory meningioma on squash preparations, in comparision with other cytologic mimickers. A 54-year-old woman presented with hearing loss, vertigo, tinnitus, and headache for seven years. A brain MRI study revealed a 4.5cm sized mass in the cerebellopontine angle, which showed homogenous signal intensity in T2-weighted image. The intraoperative squash smear showed some well-defined, thin rimmed intracytoplasmic inclusions, containing a finely granular eosinophilic core among less cohesive meningiomatous cells. Histologic sections revealed a meningothelial meningioma with scattered inclusions, with periodic acid-Schiff, carcinoembryonic antigen, and cytokeratin positivity. Identification of characteristic intracytoplasmic inclusions is helpful for diagnosing secretory meningiomas. On squash preparations, differential diagnoses included tumors with inclusions or cytoplasmic vacuolizations, such as metastatic mammary infiltrating ductal carcinoma, gastric adenocarcinoma, hepatocellular carcinoma, and clear cell ependymoma, oligodendroglioma, hemangioblastoma, chordoma, and other variants of meningiomas (clear cell, xanthomatous, microcytic, and chordoid variants). In addition, the possibilities of glioma with eosinophilic granular body, and metastatic tumors from mammary infiltrating ductal carcinoma, gastric adenocarcinoma, and hepatocellular carcinoma in meningioma should be considered.
Keywords
Brain; Neoplasm; Secretory meningioma; Cytology; Squash preparation;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Louis DN, Scheithauer BW, Budka H, von Deimling A, Kepes JJ. Meningiomas. In : Kleihues P, Cavenee WK. Pathology & Genetics Tumours of the Nervous System. Lyon: IARC Press, 2000;176-84
2 명나혜， 지제근. 분비성 수막종 1예 보고. 대한병리학회지 1993;27:64-8
3 Jeong HS, Lee GK. Secretory meningioma -a case report with histopathological, immunohistochemical and ultra-structural analysis. J Koreaη Med Sci 1996;11:369-72   DOI
4 장종희， 장진우， 박용구， 김태승. Secretory meningioma with elevated serum carcinoembryonic antigen. 대한신경외과학회지 2003;34:153-5
5 Probst-Cousin S, Villagran-Lillo R, Labl R, Bergmann M, Schmd KW, Gullotta F. Secretory meningioma: Clinical, histologic, and immunohistochemical findings in 31 cases. Cancer 1997;79:2001-15
6 Hinton DR, Kovacs K, Chandrasoma PT. Cytologic features of secretory meningioma. Acta Cytol 1999;43:121-5   DOI   PUBMED   ScienceOn
7 Buerger PC, Scheithauer BW, Vogel FS. Surgical pathology of the nervous system and its coverings. 4th ed. New York: Churchill Livingstone, 2002; 210-2
8 김동석， 이은희， 심영란， 김상표， 김오룡. 분비성 수막종-2예 보고- 대한병리학회지 1995;29:361-7
9 Schmitt HP. Metastases of malignant neoplasm to intracranial tumours: the 'tumour-in a tumour' phenomenon. Virchows Arch 1984;405:155-60   DOI
10 Katsetos CD, Krishna L, Friedberg E, Reidy J, Karkavelas G, Savory J. Lobar pilocytic astrocytomas of the cerebral hemispheres: II. Pathobiology-Morphogenesis of the eosino-philic granular bodies. Clin Neuropathol 1994;13:306-14   PUBMED
11 조영대， 강연구， 김대현， 여형태. 접형골 뇌수막종과 동시 발생한 뇌하수체선종. 대한신경외과학회지 2002;32:395-8