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Qualification of Atypical Squamous Cells of Undetermined Significance - "ASCUS, R/O HSIL" : Cytologic Features and Histologic Correlation  

Kim, Hye-Sun (Department of Pathology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine)
Kim, Bock-Man (Department of Pathology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine)
Kim, Yee-Jung (Department of Pathology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine)
Kim, Hy-Sook (Department of Pathology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine)
Publication Information
The Korean Journal of Cytopathology / v.13, no.1, 2002 , pp. 14-20 More about this Journal
Abstract
Cytologic and histopathologic features and human papillomavirus (HPV) DNA detection associated with 101 cervicovaginal smears which are ciassified as 'atypical squamous cells of undetermined significance, rule out high grade squamous intraepithelial lesion(ASCUS, R/O HSIL)' were reviewed and compared to 89 smears of 'ASCUS, not otherwise specified(NOS)'. Cytologic fieatures of ASCUS, R/O HSIL included atypical single small cells(36.6%), hyperchromatic tissue flagments(35.6%), atypical metaplastic cells(18.8%), endometrial cell-like clusters(5.9%), and atypical parakeratotic cells(3.0%). A final diagnosis of HSIL on biopsy was assigned to 47(54.0%) of 87 women with ASCUS, R/O HSIL and to 13(14.6%) of 89 women with ASCUS, NOS (p=0.000). There was no difference in HPV DNA detection late between ASCUS, R/O HSIL and ASCUS, NOS smears. These data suggest that subclassification of ASCUS is helpful to manage patients because ASCUS, R/O HSIL is more often associated with an underlying HSIL on biopsy. Therefore, women with ASCUS, rule out HSIL should be actively managed with colposcopic examination.
Keywords
Cervical smears; The Bethesda System; ASCUS; High grade squamous intraepithelial lesion;
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