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http://dx.doi.org/10.5999/aps.2014.41.1.35

Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue  

Cho, Moon Kyun (Department of Dermatology, Soonchunhyang University College of Medicine)
An, Je Min (Department of Dermatology, Soonchunhyang University College of Medicine)
Kim, Chul Han (Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine)
Kang, Sang Gue (Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine)
Publication Information
Archives of Plastic Surgery / v.41, no.1, 2014 , pp. 35-39 More about this Journal
Abstract
Background Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. Methods Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. Results Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining. Conclusions Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
Keywords
Skin; Diabetes mellitus;
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