Browse > Article

Treatment of Diabetic Ulcer Using Autologous Fibroblast-Hyaluronic Acid Complex  

Eum, Soo Jin (Department of Plastic Surgery Korea University College of Medicine)
Han, Seung Kyu (Department of Plastic Surgery Korea University College of Medicine)
Gu, Ja Hea (Department of Plastic Surgery Korea University College of Medicine)
Jeong, Seong Ho (Department of Plastic Surgery Korea University College of Medicine)
Kim, Woo Kyung (Department of Plastic Surgery Korea University College of Medicine)
Publication Information
Archives of Plastic Surgery / v.36, no.5, 2009 , pp. 548-554 More about this Journal
Abstract
Purpose: To evaluate clinical efficacy and safety of hyaluronic acid based autologous dermal fibroblasts (Hyalograft 3D) in the treatment of diabetic foot ulcers. Methods: A total of 28 patients with diabetic ulcers were randomized to either the control group with nonadherent foam dressings(n=14) or the treatment group with autologous tissue - engineered grafts(n=14). Weekly assessment contained vital sign checks, ulcer size measurements, and wound photos. At 12th week, percentages of complete wound healing and mean healing times were compared. Safety was also monitored by adverse events. Results: Complete wound healing was achieved in 84.6% of the treatment group and 23.1% of the control group (p<0.005). The mean times of closures for the treatment versus control groups were 6.1 weeks and 10.9 weeks, respectively. No adverse events related to the study treatment occurred. Conclusion: The use of hyaluronic acid based autologous fibroblast grafts was found to be a safe and effective treatment for diabetic foot ulcers.
Keywords
Diabetic foot; Fibroblast cell therapy; Hyaluronic acid;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Caravaggi C, De Giglio R, Pritelli C, Sommaria M, Dalla Noce S, Faglia E, Mantero M, Clerici G, Fratino P, Dalla Paola L, Mariani G, Mingardi R, Morabito A: HYAFF 11-based autologous dermal and epidermal grafts in the treatment of noninfected diabetic plantar and dorsal foot ulcers: a prospective, Multicenter, controlled, randomized clinical trial. Diabetes Care 26: 2853, 2003   DOI   ScienceOn
2 Han SK, Choi KJ, Kim WK: Clinical application of fresh fibroblast allografts for the treatment of diabetic foot ulcers: a pilot study. Plast Reconstr Surg 114: 1783, 2004   DOI   ScienceOn
3 Altman RD, Moskowitz R: A randomized clinical trial of intra-articular sodium hyaluronate in patients with osteoarthritis of the knee: a summary: Am J Orthop 28: 3, 1999
4 Huskisson EC, Donnelly S: Hyaluronic acid in the treatment of osteoarthritis of the knee. Rheumatology(Oxford) 38: 602, 1999   DOI   ScienceOn
5 Price RD, Berrymg, Navsaria HA: Hyaluronic acid; the scientific and clinical evidence. J Plast Reconstr Aesthet Surg 60: 1110, 2007   DOI   ScienceOn
6 Hehenberger K, Heilborn JD, Brismar K, Hansson A: Inhibited proliferation of fibroblasts derived from chronic diabetic wounds and normal dermal fibroblasts treated with high glucose is associated with increased formation of 1- latate. Wound Repair Regen 6: 135, 1998   DOI   ScienceOn
7 Mengher LS, Pandher KS, Bron AJ, Davey CC: Effect of sodium hyaluronate(0.1%) on break-up time(NIBUT) in patients with dry eyes. Br J Ophthalmol 70: 442, 1986   DOI   ScienceOn
8 Lerman OZ. Galiano RD, Armour M, Levine JP, Gurtner GC: Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am J Pathol 162: 303, 2003   DOI   PUBMED   ScienceOn
9 Bullard KM, Longaker MT, Lorenz HP: Fetal wound healing: Current biology. World J Surg 27: 54, 2003   DOI   ScienceOn
10 Shim JS, Han SK, Kim WK: Fresh Fibroblast Allograft as a Treatment for Diabetic Foot Ulcers. J Korean Soc Plast Reconstr Surg 35: 501, 2008   ScienceOn
11 De Loecker W, Koptelov VA, Grischenko VI, De Loecker P: Effects of cell concentration on viability and metabolic activity during cryopreservation. Cryobiology 37: 103, 1998   DOI   ScienceOn
12 Kano M, Masuda T, Tominaga T, Hori T, Kotaichi T, Yoshizumi M, Kotagawa T: Collagen synthesis and collagenase activity of cryopreserved heart valves. J Thorac Cardiovasc Surg 122: 706, 2001   DOI   ScienceOn
13 Liu K, Yang Y, Mansbridge J: Comparison of the stress response to cryopreservation in monolayer and three-dimensional human fibroblast cultures: stress proteins, MAP kinases, and growth factor gene expression. Tissue Eng 6: 539, 2000   DOI   ScienceOn