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Serum Collagen Level as a Predictor of Healing Wounds in Diabetic Foot Patients  

Gu, Ja-Hea (Department of Plastic Surgery, Korea University College of Medicine)
Han, Seung-Kyu (Department of Plastic Surgery, Korea University College of Medicine)
Kim, Woo Kyung (Department of Plastic Surgery, Korea University College of Medicine)
Publication Information
Archives of Plastic Surgery / v.35, no.5, 2008 , pp. 491-494 More about this Journal
Abstract
Purpose: When deciding a treatment plan in diabetic foot ulcer patients, predicting a possibility of healing wounds is important since not a few patients have poor general condition to get successful wound healing. This study was planned to find out if a serum collagen level can be used as a predictor for healing wounds in diabetic foot patients. Methods: Fifty-seven patients, who visited our clinic from January to June, 2007 for treatment of diabetic foot ulcers, were included in this study. Serum levels of type I collagen were checked using carboxy terminal type I propeptide kits. Simultaneously serum levels of vitamin C and iron, cofactors of collagen synthesis, were checked. The patients were divided into two groups; a group of successfully healed wounds and the other of unhealed wounds. Serum levels of the parameters were compared between the 2 groups. Results: The serum level of collagen was $197.65{\pm}86.26ng/ml$ in a healed group and $87.91{\pm}28.76ng/ml$ in the unhealed group(p<0.05). The serum iron and vitamin C levels were did not show significant differences. Conclusion: The serum collagen level may predict healing or nonhealing wounds in diabetic foot ulcers.
Keywords
Diabetic foot; Wound healing; Serum collagen level;
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Times Cited By KSCI : 1  (Citation Analysis)
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