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The Wound Healing Effects of Alginate- crosslinked Collagen Dermal Substitute of Artificial Skin  

Chang, Jae Hoon (Department of Plastic and Reconstructive Surgery, Daegu Catholic University)
Park, Dae Hwan (Department of Plastic and Reconstructive Surgery, Daegu Catholic University)
Shin, Jeong Im (School of Medicine & Tissue Engineering Center, Daegu Catholic University)
Ahn, Ki Young (Department of Plastic and Reconstructive Surgery, Daegu Catholic University)
Song, Chul Hong (Department of Plastic and Reconstructive Surgery, Daegu Catholic University)
Publication Information
Archives of Plastic Surgery / v.33, no.1, 2006 , pp. 13-20 More about this Journal
Abstract
Alginate, which is isolated from brown seaweed, is a bioabsorbable long chain polysaccharides, ${\beta}$-D-mannuronic acid and ${\alpha}$-L-guluronic acid. The authors produced alginates and alginate-colllagen as a disc form. Then, to evaluate the efficacy of alginate and alginate-collagen complex as a wound healing material, three full-thickness skin defects of 2 cm in diameter were made at the back of the New Zealand white rabbits. Three groups of dressing materials-alginate, alginate-collagen complex and vaseline gauze as control group - were applied on the wound and the results were evaluated grossly and histopathologically. The authors compared gross findings of sizes of healed wound, wound epithelization and wound contraction by tracing the remaining wound area at 5th, 10th, 15th, 20th, 25th day after wound introduction, and wound biopsy was performed at 3rd, 7th, 14th, 21st day, respectively. Alginate and alginate-collagen complex showed statistically higher percentage of wound contraction and wound healing compared to control group(p<0.05). Alginate-collagen complex showed statistically higher percentage of wound contraction, epithelization and wound healing compared to alginate alone. In conclusion, the result suggests that alginate has a good effect of wound healing and that alginate-collagen complex is more effective in wound healing than alginate alone.
Keywords
Alginate; Alginate-collagen complex; Wound healing;
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