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http://dx.doi.org/10.1007/s43188-022-00123-7

Protective efficacy of Coriandrum sativum seeds against arsenic induced toxicity in Swiss albino mice  

Kumar, Arun (Research Centre, Mahavir Cancer Sansthan and Research Centre)
Kumar, Vikas (Department of Biotechnology, Anugrah Narayan College)
Akhouri, Vivek (Department of Biotechnology, Anugrah Narayan College)
Kumar, Ranjit (Department of Animal Sciences, Central University of Himachal University)
Ali, Mohammad (Research Centre, Mahavir Cancer Sansthan and Research Centre)
Rashmi, Tuhin (Department of Biotechnology, Amity University)
Chand, Gyanendra Bahadur (Department of Zoology, Patna University)
Singh, Sushil Kumar (Department of Biotechnology, Anugrah Narayan College)
Ghosh, Ashok Kumar (Research Centre, Mahavir Cancer Sansthan and Research Centre)
Publication Information
Toxicological Research / v.38, no.4, 2022 , pp. 437-447 More about this Journal
Abstract
Arsenic poisoning in ground water is one of the most sensitive environmental pollutant causing serious pollution all over the world. Chronic arsenic exposure through drinking water to humans leads to major public health related issues. There have been very meagre studies which reported that, the plant constituents proved to exhibit protective effect from arsenicosis. Therefore, the present study aims to evaluate the protective efficacy of Coriandrum sativum seeds extract against sodium arsenite induced toxicity in Swiss albino mice. In the present study twenty-four male healthy Swiss albino mice (30±5 g) were divided into four groups (n=6), where the control group received normal diet and water; group II and group III treated with sodium arsenite (2 mg per kg body weight per day) for 2 and 4 weeks respectively. The group IV mice were administered with C.sativum seeds extract at the dose of 150 mg per kg body weight per day for 4 weeks upon sodium arsenite pretreated (2 mg/kg body weight for 4 weeks per day) mice. After the complete dose duration, all the treatment group animals were sacrificed same day for haematological, biochemical and histopathological study. In the arsenic treated mice, there were significant (p<0.0001) changes in the serum levels of ALT, AST, ALP, urea, uric acid and creatinine as well as in the haematological parameters. In contrast, after the administration with C.sativum seeds extract upon arsenic pretreated mice, there was significant (p<0.0001) improvement observed in the hepatic and renal biomarker parameters as well as haematological variables. In the arsenic intoxicated mice, after administration with C.sativum seeds extract there was significant (p<0.0001) reduction in the arsenic concentration in blood, liver and kidney tissues as well as in the serum LPO levels. Furthermore, the histopathological study showed that, C.sativum seeds extract administrated group of mice significantly restored the liver and kidney at cellular level against arsenic induced toxicity. The entire study concludes that C.sativum seeds extract possesses the ameliorative effect against arsenic induced liver and kidney intoxication.
Keywords
Sodium arsenite; Coriandrum sativum seeds; Hepato-renal protection; Swiss albino mice;
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1 Chakraborti D, Rahman MM, Ahamed S, Dutta RN, Pati S, Mukherjee SC (2016) Arsenic contamination of groundwater and its induced health effects in Shahpur block, Bhojpur district, Bihar state, India: risk evaluation. Environ Sci Pollut Res Int 23:9492-9504. https://doi.org/10.1007/s11356-016-6149-8   DOI
2 Aposhian HV, Aposhian MM (1989) Newer developments in arsenic toxicity. J Am Coll Toxicol 8:1297-1305. https://doi.org/10.3109/10915818909009121   DOI
3 Li D, Morimoto K, Takeshita T, Lu Y (2001) Arsenic induces DNA damage via reactive oxygen species in human cells. Environ Health Prev Med 6:27. https://doi.org/10.1007/BF028 97306   DOI
4 Levent G, Ali A, Ahmet A, Polat EC, Aytac C, Ayse E, Ahmet S (2006) Oxidative stress and antioxidant defense in patients with chronic hepatitis C patients before and after pegylated interferon alfa-2b plus ribavirin therapy. J Transl Med 4:25. https://doi.org/10.1186/1479-5876-4-25   DOI
5 Sriti J, Wannes WA, Talou T, Mhamdi B, Hamdaoui G, Marzouk B (2010) Lipid, fatty acid and tocol distribution of coriander fruit's different parts. Ind Crops Prod 31:294-300. https://doi.org/10.1016/j.indcr op.2009.11.006   DOI
6 Divya P, Puthusseri B, Neelwarne B (2012) Carotenoid content, its stability during drying and the antioxidant activity of commercial coriander (Coriandrum sativum L.) varieties. Food Res Int 45:342-350. https://doi.org/10.1016/j.foodr es.2011.09.021   DOI
7 Reische DW, Lillard DA, Eitenmiller RR (2002) Antioxidants. In: Akoh CC, Min DB (eds) Food lipids, 2nd edn. Marcel Dekker, NY, pp 489-516
8 Ferzand R, Gadahi JA, Saleha S, Ali Q (2008) Histological and haematological disturbance caused by arsenic toxicity in mice model. Pak J Biol Sci 11:1405-1413. https://doi.org/10.3923/pjbs.2008.1405.1413   DOI
9 Manna P, Sinha M, Sil PC (2008) Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid. Arch Toxicol 82:137-149. https://doi.org/10.1007/s00204-007-0272-8   DOI
10 Fatmi N, Fatima N, Shahzada MZ, Sharma S, Kumar R, Ali M, Kumar A (2017) Effect of aqueous extracts of green tea in arsenic induced toxicity in mice. Open J Plant Sci 2:011-014
11 Schnellmann RG (2001) Toxic responses of the kidney, chapter 14. In: Klaassen D (ed) Casarett and doull's toxicology, 6th edn. The McGraw-Hill Companies, Columbus, pp 491-502
12 Saxena PN, Anand S, Saxena N, Bajaj P (2009) Effect of arsenic trioxide on renal functions and its modulation by Curcuma aromatica leaf extract in albino rat. J Environ Biol 30:527-531
13 Gross JL, De Azevedo MJ, Silveiro SP, Canani LH, Caramori ML, Zelmanovitz T (2005) Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes Care 28:164-176. https://doi.org/10.2337/diacare.28.1.164   DOI
14 Msaada K, Jemia MB, Salem N, Bachrouch O, Sriti J, Tammar S, Bettaieb I, Jabri I, Kefi S, Limam F, Marzouk B (2017) Antioxidant activity of methanolic extracts from three coriander (Coriandrum sativum L.) fruit varieties. Arab J Chem 10:S3176-S3183. https://doi.org/10.1016/j.arabjc.2013.12.011   DOI
15 Barai M, Ahsan N, Paul N, Hossain K, Abdur Rashid M, Kato M, Ohgami N, Azim Akhand A (2017) Amelioration of arsenicinduced toxic effects in mice by dietary supplementation of Syzygium cumini leaf extract. Nagoya J Med Sci 79:167-177. https://doi.org/10.18999/nagjms.79.2.167   DOI
16 Majhi CR, Khan S, Leo MDM, Manimaran A, Sankar P, Sarkar SN (2011) Effects of acetaminophen on reactive oxygen species and nitric oxide redox signaling in kidney of arsenic-exposed rats. Food Chem Toxicol 49:974-982. https://doi.org/10.1016/j.fct.2011.01.003   DOI
17 Kumar V, Akhouri V, Singh SK, Kumar A (2020) Phytoremedial effect of Tinospora cordifolia against arsenic induced toxicity in Charles Foster rats. Biometals 33:379-396. https://doi.org/10.1007/s10534-020-00256-y   DOI
18 Mershiba SD, Dassprakash MV, Saraswathy SD (2013) Protective effect of naringenin on hepatic and renal dysfunction and oxidative stress in arsenic intoxicated rats. Mol Biol Rep 40:3681-3691. https://doi.org/10.1007/s11033-012-2444-8   DOI
19 Lu M, Wang H, Li XF, Lu X, Cullen WR, Arnold LL, Cohen SM, Le XC (2004) Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood. Chem Res Toxicol 17:1733-1742. https://doi.org/10.1021/tx049756s   DOI
20 Erslev AJ, Gabuzda TG (1979) Pathophysiology of hematologic disorder. In: Sodeman WA, Sodeman TM (eds) Pathologic physiology, mechanisms of diseases, 6th edn. WB Saunders Company, Philadelphia, pp 587-741
21 Islam MZ, Awal MA, Mostofa M, Ghosh A, Khair A (2009) Effect of spinach against arsenic toxicity in rats. Bangladesh J Vet Med 7:358-363
22 Chung RT (2017) Detoxification effects of phytonutrients against environmental toxicants and sharing of clinical experience on practical applications. Environ Sci Pollut Res Int 24:8946-8956. https://doi.org/10.1007/s11356-015-5263-3   DOI
23 Sharma V, Kansal L, Sharma A (2010) Prophylactic efficacy of Coriandrum sativum (Coriander) on testis of lead-exposed mice. Biol Trace Elem Res 136:337-354. https://doi.org/10.1007/s12011-009-8553-0   DOI
24 Singh SK, Ghosh AK, Kumar A, Kislay K, Kumar C, Tiwari RR, Parwez R, Kumar N, Imam MD (2014) Groundwater arsenic contamination and associated health risks in Bihar, India. Int J Environ Res 8:49-60. https://doi.org/10.22059/IJER.2014.693   DOI
25 Tchounwou P (1999) Development of Public health advisories for arsenic in drinking water. Rev Environ Health 14:211-230. https://doi.org/10.1515/reveh.1999.14.4.211   DOI
26 NRC (1999) Arsenic in drinking water. National Research Council, National Academy of Sciences, Washington
27 Rahman W (2006) Arsenic exposure in Bangladesh: the reproductive and developmental health effects in humans. In: Proceedings of the Philadelphia annual meeting. pp 67-93
28 Chakraborti D, Mukherjee SC, Pati S, Sengupta MK, Rahman MM, Chowdhury UK, Lodh D, Chanda CR, Chakraborti AK, Basu GK (2003) Arsenic groundwater contamination in Middle Ganga Plain, Bihar, India: a future danger? Environ Health Perspect 111:1194-1201. https://doi.org/10.1289/ehp.5966   DOI
29 Kumar A, Ali M, Kumar R, Rahman SM, Srivastava A, Chayal KN, Sagar V, Kumari R et al (2019) High arsenic concentration in blood samples of People of village Gyaspur Mahaji, Patna, Bihar Drinking Arsenic-Contaminated Water. Expo Health 12:1-10. https://doi.org/10.1007/s11356-021-18207-6   DOI
30 Kumar A, Rahman M, Iqubal M, Ali M, Niraj PK, Anand G et al (2016) Ground water arsenic contamination: a local survey in India. Int J Prev Med 7:100. https://doi.org/10.4103/2008-7802.188085   DOI
31 Kumar A, Rahman MS, Kumar R, Ali M, Niraj PK, Srivastava A et al (2019) Arsenic contamination in groundwater causing impaired memory and intelligence in school children of Simri village of Buxar district of Bihar. J Ment Health Hum Behav 24:132-138. https://doi.org/10.4103/jmhhb.jmhhb_31_18   DOI
32 Patra PH, Bandyopadhyay S, Kumar R, Datta BK, Maji C, Biswas S, Dash JR, Sar TK, Sarkar S, Manna SK, Chakraborty AK (2012) Quantitative imaging of arsenic and its species in goat following long term oral exposure. Food Chem Toxicol 50:1946-1950. https://doi.org/10.1016/j.fct.2012.03.072   DOI
33 Kapaj S, Peterson H, Liber K, Bhattacharya P (2006) Human health effects from chronic arsenic poisoning-a review. J Environ Sci Health Part A 41:2399-2428. https://doi.org/10.1080/10934520600873571   DOI
34 Mazumder DG (2008) Chronic arsenic toxicity and human health. Indian J Med Res 128:436-447
35 Mansoor SA, Al-khamis KI, Mohammad WI, Parmar NS, Tariq M, Ageel AM (1987) Post-coital antifertility activity of the seeds of Coriandrum sativum in rats. J Ethnopharmacol 21:165-173. https://doi.org/10.1016/0378-8741(87)90126-7   DOI
36 Kansal L, Sharma V, Sharma A, Lodi S, Sharma SH (2011) Protective role of Coriandrum sativum (coriander) extracts against lead nitrate induced oxidative stress and tissue damage in the liver and kidney in male mice. Int J Appl Biopharm Tech 2:65-83. https://doi.org/10.13040/IJPSR. 0975-8232.4(7).2789-93   DOI
37 Kumar A, Ali Md, Md RS, Md IA, Anand G et al (2015) Ground water arsenic poisoning in "Tilak Rai Ka Hatta" village of Buxar district, Bihar, India causing severe health hazards and hormonal imbalance. J Environ Anal Toxicol 5:290. https://doi.org/10.4172/2161-0525. 10002 90   DOI
38 Fawcett JK, Scott J (1960) A rapid and precise method for the determination of urea. J Clin Pathol 13:156-159. https://doi.org/10.1136/jcp.13.2.156   DOI
39 Fatima N, Fatmi N, Shahzada MZ, Sharma S, Kumar R, Ali M (2017) Hepatoprotective effect of Ferula assafoetida against arsenic induced toxicity in Swiss albino mice. J Drug Discov Dev Deliv 4:1030
40 Reitman S, Frankel S (1957) A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28:56-63. https://doi.org/10.1093/ajcp/28.1.56   DOI
41 Berthelot MPE (1859) Berthelot's reaction mechanism. Rep Chim Appl 384:2884
42 Bones RW, Tausky HH (1945) Colorimetric determination of creatinine by the Jaffe reaction. J Biol Chem 158:581-591   DOI
43 Fossati P, Prencipe L (1980) Enzymatic colorimetric method of the determination of uric acid in serum. Clin Chem 26:227-231   DOI
44 Draper HH, Hadley M (1990) Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 186:421-431. https://doi.org/10.1016/0076-6879(90)86135-i   DOI
45 Velaga MK, Yallapragada PR, Williams D, Rajanna S, Bettaiya R (2014) Hydroalcoholic seed extract of Coriandrum sativum (Coriander) alleviates lead-induced oxidative stress in different regions of rat brain. Biol Trace Elem Res 159:351-363. https://doi.org/10.1007/s12011-014-9989-4   DOI
46 Eaves-Pyles T, Wong HR, Alexander JW (2000) Sodium arsenite induces the stress response in the gut and decreases bacterial translocation in a burned mouse model with gut-derived sepsis. Shock (Augusta, Ga.) 13:314-319. https://doi.org/10.1097/00024382-200004000-00010   DOI
47 Chithra V, Leelamma S (2000) Coriandrum sativum-effect on lipid metabolism in 1, 2-dimethyl hydrazine induced colon cancer. J Ethnopharmacol 71:457-463. https://doi.org/10.1016/s0378-8741(00)00182-3   DOI
48 Sharma MM, Sharma RK (2004) Coriander. In: Peter KV (ed) Handbook of herbs and spices, vol 2. CRC, Woodhead Publishing Limited, Sawston, pp 145-161
49 Wangensteen H, Samuelsen AB, Malterud KE (2004) Antioxidant activity in extracts from coriander. Food Chem 88:293-297. https://doi.org/10.1016/j. foodc hem. 2004. 01. 047   DOI
50 Cortes-Eslava J, Gomez-Arroyo S, Villalobos-Pietrini R, Espinosa-Aguirre JJ (2004) Antimutagenicity of coriander (Coriandrum sativum) juice on the mutagenesis produced by plant metabolites of aromatic amines. Toxicol Lett 153:283-292. https://doi.org/10.1016/j.toxlet.2004.05.011 26   DOI
51 Meloa EA, Filhob JM, Guerrac NB (2005) Characterizations of antioxidant compounds in aqueous coriander extract (Coriandrum sativum L.). Leb Wiss Technol 38:15-19. https://doi.org/10.1016/j.lwt.2004.03.011   DOI
52 Rahman MS, Kumar A, Kumar R, Ali M, Ghosh AK, Singh SK (2019) Comparative quantification study of arsenic in the groundwater and biological samples of Simri village of Buxar District, Bihar, India. Indian J Occup Environ Med 23:126-132. https://doi.org/10. 4103/ijoem. IJOEM_240_18   DOI
53 Muthumani M, Miltonprabu S (2012) Arsenic induced oxidative stress and its possible reversal by chelation therapy. Res Rev J Toxicol 2:16-37
54 Dua A, Garg G, Kumar D, Mahajan R (2014) Polyphenolic composition and antimicrobial potential of methanolic coriander (Coriandrum sativum) seed extract. Int J Pharm Sci Res 5:2302. https://doi.org/10.13040/IJPSR.0975-8232.5(6).2302-08   DOI
55 Aissaoui A, Zizi S, Israili ZH, Lyoussi B (2011) Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats. J Ethnopharmacol 137:652-661. https://doi.org/10.1016/j.jep.2011.06.019   DOI
56 Filomena S, Susana F, Andreia D (2011) Antifungal activity of Coriandrum sativum essential oil, its mode of action against Candida species and potential synergism with amphotericin B. Phytomedicine 2011:1-6. https://doi.org/10.1016/j.phymed.2011.06.033   DOI
57 Dhanapakiam P, Joseph JM, Ramaswamy VK, Moorthi M, Kumar AS (2007) The cholesterol lowering property of coriander seeds (Coriandrum sativum): mechanism of action. J Environ Biol 29:53-56
58 Miller WH, Schipper HM, Lee JS, Singer J, Waxman S (2002) Mechanisms of action of arsenic trioxide. Can Res 62:3893-3903
59 Wangensteen H, Samuelsen AB, Malterud KE (2004) Antioxidant activity in extracts from coriander. Food Chem 88:293-297. https://doi.org/10.1016/j.foodchem.2004.01.047   DOI
60 NIOSH (National Institute for Occupational Safety and Health) (1994) Elements in blood or tissue. Method: 8005. In: NIOSH manual of analytical methods, vol 4. OH Cincinnati: Department of Health and Human Service, National Institute of Occupational Safety and Health. DHHS Publication pp. 94-113. https://www.cdc.gov/niosh/docs/2003-154/pdfs/8005.pdf
61 Hsueh YM, Chung CJ, Shiue HS, Chen JB, Chiang SS, Yang MH, Tai CW, Su CT (2009) Urinary arsenic species and CKD in a Taiwanese population: a case-control study. Am J Kidney Dis 54:859-870. https://doi.org/10.1053/j.ajkd.2009.06.016   DOI
62 Caldwell KL, Jones RL, Verdon CP, Jarrett JM, Caudill SP, Osterloh JD (2009) Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003-2004. J Eposure Sci Environ Epidemiol 19:59-68. https://doi.org/10.1038/jes.2008.32   DOI
63 Watanabe T, Hirano S (2013) Metabolism of arsenic and its toxicological relevance. Arch Toxicol 87:969-979. https://doi.org/10.1007/s00204-012-0904-5   DOI
64 Fatima N, Fatmi N, Shahzada MZ, Sharma S, Kumar R, Ali M, Kumar A (2018) Ameliorating effect of Cucumis sativus (Cucumbers) against arsenic induced toxicity in mice. Open J Pathol 8:78-84. https://doi.org/10.4236/ojpat hology.2018.83009   DOI
65 Iqbal MJ, Butt MS, Suleria HAR (2019) Coriander (Coriandrum sativum L.): bioactive molecules and health effects. In: Merillon JM, Ramawat K (eds) Bioactive molecules in food reference series in phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-78030-6_44   DOI
66 Ghosh A, Mandal AK, Sarkar S, Das N (2011) Hepatoprotective and neuroprotective activity of liposomal quercetin in combating chronic arsenic induced oxidative damage in liver and brain of rats. Drug Deliv 18:451-459. https://doi.org/10.3109/10717 544.2011. 577110   DOI
67 Chakraborti D, Singh SK, Rahman MM, Dutta RN, Mukherjee SC, Pati S, Kar PB (2018) Groundwater arsenic contamination in the Ganga River Basin: a future health danger. Int J Environ Res Public Health 15:180. https://doi.org/10.3390/ijerph15020180   DOI
68 Aga M, Iwaki K, Ueda Y, Ushio S, Masaki N, Fukuda S, Kimoto T, Ikeda M, Kurimoto M (2001) Preventive effect of Coriandrum sativum (Chinese parsley) on localized lead deposition in ICR mice. J Ethnopharmacol 77:203-208. https://doi.org/10.1016/s0378-8741(01)00299-9   DOI
69 Kang LP, Qi LH, Zhang JP, Shi N, Zhang M, Wu TM, Chen J (2001) Effect of genistein and quercetin on proliferation, collagen synthesis, and type I procollagen mRNA levels of rat hepatic stellate cells. Acta Pharmacol Sin 22:793-796
70 Mao YQ, Liu XJ, Jiang Y, Wu HB (2004) Effect of quercetin on the signal pathway of TGFbeta1 in activated hepatic stellate cells. Sichuan da xue xue bao. Yi xue ban= J Sichuan Univ Med Sci Ed 35:802-805
71 Khrenova DK, Dargaeva TD, Nikolaev SM, Fedotovskikh NN, Brutko LI (1986) Qualitative phytochemical analysis of antiulcerous drug prepared from plants. Farmatsiya Mosc 35:46-48
72 Pandey A, Bigoniya P, Raj V, Patel KK (2011) Pharmacological screening of Coriandrum sativum Linn. for hepatoprotective activity. J Pharm Bioallied Sci 3:435. https://doi.org/10.4103/0975-7406.84462   DOI
73 Kind PRH, King EJ (1954) Determination of alkaline phosphatase activity in serum. J Clin Pathol 7:322-326. https://doi.org/10.1136/jcp.7.4.322   DOI
74 Lakhera A, Ganeshpurkar A, Bansal D, Dubey N (2015) Chemopreventive role of Coriandrum sativum against gentamicininduced renal histopathological damage in rats. Interdiscip Toxicol 8:99-102. https://doi.org/10.1515/intox-2015-0015   DOI
75 Sharma V, Kansal L, Sharma A, Lodi S, Sharma SH (2011) Ameliorating effect of Coriandrum sativum extracts on hematological and immunological variables in an animal model of lead intoxication. J Pharm Allied Health Sci 1:16-29. https://doi.org/10.3923/jpahs.2011.16.29   DOI