Acute toxicity of aqueous extract of Ambrosia arborescens Mill. on biochemical and histopathological parameters in rats |
Silva‑Correa, Carmen R.
(Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo)
Torre, Víctor E. Villarreal‑La (Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo) Gonzalez‑Siccha, Anabel D. (Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo) Cruzado‑Razco, Jose L. (Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo) Gonzalez‑Blas, Maria V. (Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo) Sagastegui‑Guarniz, William Antonio (Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo) Calderon‑Pena, Abhel A. (Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo) Aspajo‑Villalaz, Cinthya L. (Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo) Hilario‑Vargas, Julio (Facultad de Medicina, Universidad Nacional de Trujillo) |
1 | de Araujo MC PM, Barcellos NMS, de Vieira PM A, Gouveia TM, Guerra MO, Peters VM et al (2017) Acute and sub chronic toxicity study of aqueous extract from the leaves and branches of Campomanesia velutina (Cambess) O Berg. J Ethnopharmacol 201:17-25. https://doi.org/10.1016/j.jep.2017.02.043 DOI |
2 | Han C-T, Kim M-J, Moon S-H, Jeon Y-R, Hwang J-S, Nam C et al (2015) Acute and 28-day subacute toxicity studies of hexane extracts of the roots of Lithospermum erythrorhizon in Sprague-Dawley rats. Toxicol Res 31:403-414. https://doi.org/10.5487/TR.2015.31.4.403 DOI |
3 | Morales G, Paredes A, Olivares A, Bravo J (2014) Acute oral toxicity and anti-inflammatory activity of hydroalcoholic extract from Lampaya medicinalis phil in rats. Biol Res 47:6. https://doi.org/10.1186/0717-6287-47-6 DOI |
4 | Li Y, Kandhare AD, Mukherjee AA, Bodhankar SL (2019) Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats. Regul Toxicol Pharmacol 105:77-85. https://doi.org/10.1016/j.yrtph.2019.04.001 DOI |
5 | Aydin A, Aktay G, Yesilada E (2016) A guidance manual for the toxicity assessment of traditional herbal medicines. Nat Prod Commun 11:1763-1773. https://doi.org/10.1177/1934578X1601101131 DOI |
6 | Instituto Nacional de Salud (2008) Guia de manejo y cuidado de animales de laboratorio: raton. https://repositorio.ins.gob.pe/xmlui/bitstream/handle/INS/117/CNPB-0002.pdf?sequence=3&isAllowed=y. Accessed 15 Apr 2021 |
7 | Rojas-Armas J, Arroyo-Acevedo J, Ortiz-Sanchez M, Palomino-Pacheco M, Castro-Luna A, Ramos-Cevallos N et al (2019) Acute and repeated 28-day oral dose toxicity studies of Thymus vulgaris L. essential oil in rats. Toxicol Res 35:225-232. https://doi.org/10.5487/TR.2019.35.3.225 DOI |
8 | Ribeiro NE, Pereira PS, de Oliveira TB, de Arruda Lima SM, Silva TMS, Santana ALBD et al (2020) Acute and repeated dose 28-day oral toxicity of Chrysobalanus icaco L. leaf aqueous extract. Regul Toxicol Pharmacol 113:104643. https://doi.org/10.1016/j.yrtph.2020.104643 DOI |
9 | Kim HY, Zuo G, Lee SK, Lim SS (2020) Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice. Food Sci Nutr 8:2242-2250. https://doi.org/10.1002/fsn3.1465 DOI |
10 | Hazarika I, Geetha KM, Sundari PS, Madhu D (2019) Acute oral toxicity evaluation of extracts of Hydrocotyle sibthorpioides in wistar albino rats as per OECD 425 TG. Toxicol Reports 2019:321-328. https://doi.org/10.1016/j.toxrep.2019.04.001 DOI |
11 | Kognou ALM, Tchamgoue AD, Tchokouaha LRY, Nthenge-Ngumbau DN, Fokou PVT, Tchinda AT et al (2018) Acute and sub-chronic toxicity studies of Dichaetanthera africana (Hook. F.) Jacq. Fel. (Melastomataceae) stem bark ethanol extract. J Appl Pharm Sci 8:147-155. https://doi.org/10.7324/JAPS.2018.8619 DOI |
12 | Syahirah S, Hamzah H, Rosly M, Farhan M, Mohamed N, Norhaizan E (2018) Subacute oral toxicity assesment of ethanol extract of Mariposa christia vespertilionis leaves in male Sprague Dawley rats. Toxicol Res 34:85-95. https://doi.org/10.5487/TR.2018.34.2.085 DOI |
13 | Singha CH, Nath K, Kumar P, Kumar A, Dixit J, Saini R et al (2021) Toxicity profiling and antioxidant activity of ethyl acetate extract of leaves of Premna integrifolia L. for its application as protective agent against xenobiotics. Toxicol Rep 8:196-205. https://doi.org/10.1016/j.toxrep.2021.01.004 DOI |
14 | El Kabbaoui M, Chda A, El-Akhal J, Azdad O, Mejrhit N, Aarab L et al (2017) Acute and sub-chronic toxicity studies of the aqueous extract from leaves of Cistus ladaniferus L. in mice and rats. J Ethnopharmacol 209:147-156. https://doi.org/10.1016/j.jep.2017.07.029 DOI |
15 | Villagomez R, Rodrigo GC, Collado IG, Calzado MA, Munoz E, Akesson B et al (2013) Multiple anticancer effects of damsin and coronopilin isolated from Ambrosia arborescens on cell cultures. Anticancer Res 33:3799-3806 (PMID: 24023312). https://ar.iiarjournals.org/content/anticanres/33/9/3799.full.pdf |
16 | Han JS, Lee BS, Han SR, Han HY, Chung MK, Min BS et al (2016) A subchronic toxicity study of Radix Dipsaci water extract by oral administration in F344 rats. Regul Toxicol Pharmacol 81:136-145. https://doi.org/10.1016/j.yrtph.2016.07.017 DOI |
17 | The Organization for Economic Co-operation and Development (OECD). OECD guideline for testing of chemicals: acute oral toxicity-acute toxic class method (OECD 423). https://www.oecd.org/chemicalsafety/testing/45124172.pdf. Accessed 15 Apr 2021 |
18 | Atsafack SS, Kuiate JR, Mouokeu RS, Koanga Mogtomo ML, Tchinda AT, De Dieu TJ et al (2015) Toxicological studies of stem bark extract from Schefflera barteri Harms (Araliaceae). BMC Complement Altern Med 15:44. https://doi.org/10.1186/s12906-015-0581-z DOI |
19 | Committee for the Update of the Guide for the Care and Use of Laboratory Animals (2011) Guide for the care and use of laboratory animals, 8th edn. The National Academies Press, Washington |
20 | Aregullin M, Rodriguez E (2003) Sesquiterpene Lactone Sequestration by the Tortoise Beetle Physonota arizonae (Cassidinae). Rev Soc Quim Mex 47:143-145. http://www.scielo.org.mx/pdf/rsqm/v47n2/v47n2a11.pdf |
21 | Neergheen-Bhujun VS (2013) Underestimating the toxicological challenges associated with the use of herbal medicinal products in developing countries. Biomed Res Int 2013:804086. https://doi.org/10.1155/2013/804086 DOI |
22 | Saad B, Azaizeh H, Abu-Hijleh G, Said O (2006) Safety of traditional Arab herbal medicine. Evid Based Complement Altern Med 3:433-439. https://doi.org/10.1093/ecam/nel058 DOI |
23 | Al-Afifi NA, Alabsi AM, Bakri MM, Ramanathan A (2018) Acute and sub-acute oral toxicity of Dracaena cinnabari resin methanol extract in rats. BMC Complement Altern Med 18:50. https://doi.org/10.1186/s12906-018-2110-3 DOI |
24 | Yuet Ping K, Darah I, Chen Y, Sreeramanan S, Sasidharan S (2013) Acute and subchronic toxicity study of Euphorbia hirta L. methanol extract in rats. Biomed Res Int 2013:182064. https://doi.org/10.1155/2013/182064 DOI |
25 | Ruiz C, Diaz C, Rojas R (2015) Composicion Quimica de Aceites Esenciales de 10 Plantas Aromaticas Peruanas. Rev la Soc Quimica del Peru 81:81-94. https://doi.org/10.37761/rsqp.v81i2.10 DOI |
26 | De Leo M, Saltos MBV, Puente BFN, De Tommasi N, Braca A (2010) Sesquiterpenes and diterpenes from Ambrosia arborescens. Phytochemistry 71:804-809. https://doi.org/10.1016/j.phytochem.2010.02.002 DOI |
27 | Balogun FO, Tom Ashafa AO (2016) Acute and subchronic oral toxicity evaluation of aqueous root extract of Dicoma anomala Sond. in Wistar Rats. Evid Based Complement Altern Med 2016:3509323. https://doi.org/10.1155/2016/3509323 DOI |
28 | Hassanzadeh-Taheri M, Hosseini M, Salimi M, Moodi H, Dorranipour D (2018) Acute and sub-acute oral toxicity evaluation of Astragalus hamosus seedpod ethanolic extract in Wistar rats. Pharm Sci 24:23-30. https://doi.org/10.15171/PS.2018.05 DOI |
29 | Ndrepepa G (2021) Aspartate aminotransferase and cardiovascular disease-a narrative review. J Lab Precis Med 6:6. https://doi.org/10.21037/jlpm-20-93 DOI |
30 | Cano de Terrones T (2014) Caracterizacion de una espirolactona sesquiterpenica α-metilenica obtenida de Ambrosia arborescens Miller y evaluacion de su actividad biologica en Trypanosoma cruzi. Rev la Soc Quimica del Peru 80:124-135. https://doi.org/10.37761/rsqp.v80i2.157 DOI |
31 | Amadike E, Emmanuel I, Chibueze V, Gilbert J, Ekeanyanwu B (2019) Toxicological evaluation of phytochemical characterized aqueous extract of wild dried Lentinus squarrosulus (Mont.) mushroom in rats. Toxicol Res 35:181-190. https://doi.org/10.5487/TR.2019.35.2.181 DOI |
32 | Amacher D (2013) Female gender as a susceptibility factor for drug-induced liver injury. Hum Exp Toxicol 33:928-939. https://doi.org/10.1177/0960327113512860 DOI |
33 | Chebaibi M, Bousta D, Chbani L, Ez zoubi Y, Touiti N, Achour S (2019) Acute toxicity of plants mixture used in traditional treatment of edema and colic renal in Morocco. Sci Afr 6:e00152. https://doi.org/10.1016/j.sciaf.2019.e00152 DOI |
34 | Kifayatullah M, Shahimi M, Sengupta P, Rahman M, Das A, Das S (2015) Evaluation of the acute and sub-acute toxicity of the ethanolic extract of Pericampylus glaucus (Lam.) Merr. in BALB/c mice. J Acute Dis 4:309-315. https://doi.org/10.1016/j.joad.2015.06.010 DOI |
35 | Mythilypriya R, Shanthi P, Sachdanandam P (2007) Oral acute and subacute toxicity studies with kalpaamruthaa, a modified indigenous preparation, on rats. J Heal Sci 53:351-358. https://doi.org/10.1248/jhs.53.351 DOI |
36 | Yuan H, Ma Q, Ye L, Piao G (2016) The traditional medicine and modern medicine from natural products. Molecules 21:559. https://doi.org/10.3390/molecules21050559 DOI |
37 | Manekeng HT, Mbaveng AT, Ntyam Mendo SA, Agokeng AJD, Kuete V (2019) Evaluation of acute and subacute toxicities of Psidium guajava methanolic bark extract: a botanical with in vitro antiproliferative potential. Evid Based Complement Altern Med 2019:8306986. https://doi.org/10.1155/2019/8306986 DOI |
38 | Vaghasiya YK, Shukla VJ, Chanda SV (2010) Acute oral toxicity study of Pluchea arguta boiss extract in mice. J Pharmacol Toxicol 6:113-123. https://doi.org/10.3923/jpt.2011.113.123 DOI |
39 | Sotillo WS, Villagomez R, Smiljanic S, Huang X, Malakpour A, Kempengren S et al (2017) Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative. PLoS ONE 12:e0184304. https://doi.org/10.1371/journal.pone.0184304 DOI |
40 | Das B, Dasi R (1995) Chemical investigation in Parthenium hysteruphorus-an allelopathic plant. Allelopathy J 2:99-104. https://www.allelopathyjournal.com/Journal_Articles/AJ%2%(1)%January,%1995%(99-104).pdf DOI |
41 | Teves MR, Matera S, Consolini AE, Wendel GH (2020) Effect of the leaves aqueous extract of Jodina rhombifolia (Hook. & Arn.) Reissek (Santalaceae) on intestinal function and its acute toxicity. J Ethnopharmacol 262:113205. https://doi.org/10.1016/j.jep.2020.113205 DOI |
42 | Sotiropoulou NS, Megremi SF, Tarantilis P (2020) Evaluation of antioxidant activity, toxicity, and phenolic profile of aqueous extracts of chamomile (Matricaria chamomilla L.) and sage (Salvia ocinalis L.) prepared at different temperatures. Appl Sci 10:2270. https://doi.org/10.3390/app10072270 DOI |
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