Browse > Article
http://dx.doi.org/10.1007/s43188-020-00072-z

Fimbristylis ovata extract and its ability to encounter AGEs-induced neurotoxicity in SH-SY5Y  

Sirirattanakul, Suphasarang (Graduate Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University)
Santiyanont, Rachana (Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University)
Publication Information
Toxicological Research / v.37, no.3, 2021 , pp. 355-367 More about this Journal
Abstract
Advanced glycation end products (AGEs) upon binding to its receptor (receptor for AGEs, RAGE) trigger several pathological processes involving oxidative stress and inflammatory pathway which play a pivotal role in various degenerative diseases including Alzheimer's disease. Fimbristylis ovata (F. ovata) has long been reported to be used as a traditional herbal medicine; nonetheless, very few studies have been reported. In this study, the protective effects of F. ovata extract on neurotoxicity of hippocampal neuronal cells (SH-SY5Y) was investigated. When compared to normal control, AGEs treatment significantly induced oxidative stress level and enhanced NF-κB translocation to nucleus in the neuronal cells (p<0.05). The increase in NF-κB translocation leads to increase in transcription level of the target genes including RAGE and pro-inflammatory cytokines which include interleukin 1 beta (IL1B), tumor necrosis factor-alpha (TNFA) and interleukin 6 (IL6). Pre-treatment of SH-SY5Y with the extracts of F. ovata shows favorable results by significantly suppressing oxidative stress level (p<0.05) as well transcriptional level of RAGE (p<0.05) and pro-inflammatory cytokines (p<0.05). Chemical analysis of F. ovata extracts using High Resolution Liquid Chromatograph Mass Spectrometer (HR-LCMS) and Gas Chromatograph with high resolution Mass Spectrometer (GC-HRMS) suggested some potential active phytochemical compounds. The results from this study may provide possible alternative treatment for prevention and/or therapy of neurodegenerative disorders by targeting the above-mentioned pathways. The role of the phytochemical active ingredient (s) in inhibiting the AGEs-triggered signaling inflammatory pathway should be investigated in future study.
Keywords
Neurotoxicity; Oxidative stress; Pro-inflammatory cytokines; Fimbristylis ovata; SH-SY5Y;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Li J, Schmidt AM (1997) Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products. J Biol Chem 272:16498-16506. https://doi.org/10.1074/jbc.272.26.16498   DOI
2 Lanzillotta A, Porrini V, Bellucci A, Benarese M, Branca C, Parrella E, Spano PF, Pizzi M (2015) NF-κB in innate neuroprotection and age-related neurodegenerative diseases. Front Neurol 6:98. https://doi.org/10.3389/fneur.2015.00098   DOI
3 Fogal B, Hewett SJ (2008) Interleukin-1beta: a bridge between inflammation and excitotoxicity? J Neurochem 106:1-23. https://doi.org/10.1111/j.1471-4159.2008.05315.x   DOI
4 Abraham E (2000) NF-κB activation. Crit Care Med 28:N100-N104. https://doi.org/10.1097/00003246-200004001-00012   DOI
5 Tak PP, Firestein GS (2001) NF-κB: a key role in inflammatory diseases. J Clin Investig 107:7-11. https://doi.org/10.1172/JCI11830   DOI
6 Chen TT, Jiandong L, Wang G, Jiang SL, Li LB, Gao CQ (2013) Combined treatment of ulinastatin and tranexamic acid provides beneficial effects by inhibiting inflammatory and fibrinolytic response in patients undergoing heart valve replacement surgery. Heart Surg Forum 16:E38-E47. https://doi.org/10.1532/HSF98.20121072   DOI
7 Teng Y, Feng C, Liu Y, Jin H, Gao Y, Li T (2018) Anti-inflammatory effect of tranexamic acid against trauma-hemorrhagic shock-induced acute lung injury in rats. Exp Anim 67:313-320. https://doi.org/10.1538/expanim.17-0143   DOI
8 Sun YP, Jin WF, Wang YY, Wang G, Morris-Natschke SL, Liu JS, Wang GK, Lee KH (2018) Chemical structures and biological activities of limonoids from the genus Swietenia (Meliaceae). Molecules 23. https://doi.org/10.3390/molecules23071588   DOI
9 Oliveira LT, Leon GVO, Provance DW Jr, de Mello FG, Sorenson MM, Salerno VP (2015) Exogenous beta-amyloid peptide interferes with GLUT4 localization in neurons. Brain Res 1615:42-50. https://doi.org/10.1016/j.brainres.2015.04.026   DOI
10 Schnaar RL, Gerardy-Schahn R, Hildebrandt H (2014) Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. Physiol Rev 94:461-518. https://doi.org/10.1152/physrev.00033.2013   DOI
11 de Nazareth AM (2017) Type 2 diabetes mellitus in the pathophysiology of Alzheimer's disease. Dement Neuropsychol 11:105-113. https://doi.org/10.1590/1980-57642016dn11-020002   DOI
12 Choi YH (2016) The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation. Gen Physiol Biophys 35:145-154. https://doi.org/10.4149/gpb_2015034   DOI
13 Netscher T (2007) Synthesis of vitamin E, vitamins & hormones. Academic Press, Cambridge, pp 155-202. https://doi.org/10.1016/S0083-6729(07)76007-739   DOI
14 Ishola IO, Osele MO, Chijioke MC, Adeyemi OO (2019) Isorhamnetin enhanced cortico-hippocampal learning and memory capability in mice with scopolamine-induced amnesia: role of antioxidant defense, cholinergic and BDNF signaling. Brain Res 1712:188-196. https://doi.org/10.1016/j.brainres.2019.02.017   DOI
15 Zhang J, Wang Y, Dong X, Liu J (2018) Crocetin attenuates inflammation and amyloid-beta accumulation in APPsw transgenic mice. Immun Ageing 15:24. https://doi.org/10.1186/s12979-018-0132-9   DOI
16 Zhu A, Lao C, Wang Z, Chen Y, Bai C (2019) Characterization of crocetin-monoglucuronide as a neuron-protective metabolite of crocin-1. Mol Nutr Food Res e1900024. https://doi.org/10.1002/mnfr.201900024   DOI
17 Barnham KJ, Masters CL, Bush AI (2004) Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov 3:205-214. https://doi.org/10.1038/nrd1330   DOI
18 Butterfield DA, Halliwell B (2019) Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci 20:148-160. https://doi.org/10.1038/s41583-019-0132-6   DOI
19 Mattson MP, Camandola S (2001) NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Investig 107:247-254. https://doi.org/10.1172/JCI11916   DOI
20 Soman S, Raju R, Sandhya VK, Advani J, Khan AA, Harsha HC, Prasad TS, Sudhakaran PR, Pandey A, Adishesha PK (2013) A multicellular signal transduction network of AGE/RAGE signaling. J Cell Commun Signal 7:19-23. https://doi.org/10.1007/s12079-012-0181-3   DOI
21 Galic MA, Riazi K, Pittman QJ (2012) Cytokines and brain excitability. Front Neuroendocrinol 33:116-125. https://doi.org/10.1016/j.yfrne.2011.12.002   DOI
22 Fuchs CS, Simon RC, Riethorst W, Zepeck F, Kroutil W (2014) Synthesis of (R)- or (S)-valinol using ω-transaminases in aqueous and organic media. Bioorg Med Chem 22:5558-5562. https://doi.org/10.1016/j.bmc.2014.05.055   DOI
23 Wang B (2009) Sialic acid is an essential nutrient for brain development and cognition. Annu Rev Nutr 29:177-222. https://doi.org/10.1146/annurev.nutr.28.061807.155515   DOI
24 Li Y, Chi G, Shen B, Tian Y, Feng H (2016) Isorhamnetin ameliorates LPS-induced inflammatory response through downregulation of NF-κB signaling. Inflammation 39:1291-1301. https://doi.org/10.1007/s10753-016-0361-z   DOI
25 Heppner FL, Ransohoff RM, Becher B (2015) Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci 16:358. https://doi.org/10.1038/nrn3880   DOI
26 Wang X, Jiao X, Liu Z, Li Y (2017) Crocetin potentiates neurite growth in hippocampal neurons and facilitates functional recovery in rats with spinal cord injury. Neurosci Bull 33:695-702. https://doi.org/10.1007/s12264-017-0157-7   DOI
27 Alison MD, Richard JP, Mark EH, Andrew DA (2003) The synthesis of naturally occurring vitamin K and vitamin K analogues. Curr Org Chem 7:1625-1634. https://doi.org/10.2174/1385272033486279   DOI
28 Munch G, Mayer S, Michaelis J, Hipkiss AR, Riederer P, Muller R, Neumann A, Schinzel R, Cunningham AM (1997) Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide. Biochem Biophys Acta 1360:17-29. https://doi.org/10.1016/S0925-4439(96)00062-2   DOI
29 Arraki K, Totoson P, Decendit A, Badoc A, Zedet A, Jolibois J, Pudlo M, Demougeot C, Girard-Thernier C (2017) Cyperaceae species are potential sources of natural mammalian arginase inhibitors with positive effects on vascular function. J Nat Prod 80:2432-2438. https://doi.org/10.1021/acs.jnatprod.7b00197   DOI
30 Thomas S, Priya EJS (2015) Effect of Fimbristylis ovata (Burm. F) J. Kern on vero cell and MCF-7 cell morphology. J Chem Pharm Res 7:284-290. ISSN:0975-7384
31 Hemanth Kumar K, Tamatam A, Pal A, Khanum F (2013) Neuroprotective effects of Cyperus rotundus on SIN-1 induced nitric oxide generation and protein nitration: ameliorative effect against apoptosis mediated neuronal cell damage. NeuroToxicology 34:150-159. https://doi.org/10.1016/j.neuro.2012.11.002   DOI
32 Mahmoudi R, Ghareghani M, Zibara K, Tajali Ardakani M, Jand Y, Azari H, Nikbakht J, Ghanbari A (2019) Alyssum homolocarpum seed oil (AHSO), containing natural alpha linolenic acid, stearic acid, myristic acid and beta-sitosterol, increases proliferation and differentiation of neural stem cells in vitro. BMC Complement Altern Med 19:113. https://doi.org/10.1186/s12906-019-2518-4   DOI
33 Peerzada AM, Ali HH, Naeem M, Latif M, Bukhari AH, Tanveer A (2015) Cyperus rotundus L.: traditional uses, phytochemistry, and pharmacological activities. J Ethnopharmacol 174:540-560. https://doi.org/10.1016/j.jep.2015.08.012   DOI
34 Bourre JM (2004) Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing. J Nutr Health Aging 8:163-174
35 Sattler R, Tymianski M (2001) Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol Neurobiol 24:107-129. https://doi.org/10.1385/MN:24:1-3:107   DOI
36 Vitek MP, Bhattacharya K, Glendening JM, Stopa E, Vlassara H, Bucala R, Manogue K, Cerami A (1994) Advanced glycation end products contribute to amyloidosis in Alzheimer disease. Proc Natl Acad Sci USA 91:4766-4770. https://doi.org/10.1073/pnas.91.11.4766   DOI
37 Dewanjee S, Maiti A, Das AK, Mandal SC, Dey SP (2009) Swietenine: a potential oral hypoglycemic from Swietenia macrophylla seed. Fitoterapia 80:249-251. https://doi.org/10.1016/j.fitote.2009.02.004   DOI
38 Hastings TG (2009) The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease. J Bioenerg Biomembr 41:469-472. https://doi.org/10.1007/s10863-009-9257-z   DOI
39 Yamagishi S (2011) Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes. Exp Gerontol 46:217-224. https://doi.org/10.1016/j.exger.2010.11.007   DOI
40 Kamala A, Middha SK, Karigar CS (2018) Plants in traditional medicine with special reference to Cyperus rotundus L.: a review. 3 Biotech 8:309. https://doi.org/10.1007/s13205-018-1328-6   DOI
41 Sunil AG, Kesavanarayanan KS, Kalaivani P, Sathiya S, Ranju V, Priya RJ, Pramila B, Paul FDS, Venkhatesh J, Babu CS (2011) Total oligomeric flavonoids of Cyperus rotundus ameliorates neurological deficits, excitotoxicity and behavioral alterations induced by cerebral ischemic-reperfusion injury in rats. Brain Res Bull 84:394-405. https://doi.org/10.1016/j.brainresbull.2011.01.008   DOI
42 Sukjamnong S, Santiyanont R (2012) Antioxidant activity of Fimbristylis ovata and its effect on RAGE gene expression in human lung adenocarcinoma epithelial cell line. J Chem Pharm Res 4:2483-2489. ISSN: 0975-7384
43 Sukjamnong S, Santiyanont R (2015) Effect of Fimbristylis ovata on receptor for advanced glycation end-products, proinflammatory cytokines, and cell adhesion molecule level and gene expression in U937 and bEnd.3 cell lines. Genet Mol Res 14:3984-3994. https://doi.org/10.4238/2015.April.27.13   DOI