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http://dx.doi.org/10.1007/s43188-020-00061-2

β-caryophyllene improves sexual performance via modulation of crucial enzymes relevant to erectile dysfunction in rats  

Adefegha, Stephen A. (Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology)
Oboh, Ganiyu (Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology)
Olopade, Elijah O. (Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology)
Publication Information
Toxicological Research / v.37, no.2, 2021 , pp. 249-260 More about this Journal
Abstract
This study sought to investigate the effect of β-caryophyllene (BCP) on sexual performance, crucial enzymes linked to erectile function as well as lipid peroxidation in the penile tissue of paroxetine (PD)-induced rats. Animals were randomly divided into ten groups of five animals each: normal control (NC), BCP (10 mg/kg), BCP (20 mg/kg), sildenafil citrate (SD) (20 mg/kg), BCP+SD (20 mg/kg), PD (20 mg/kg), PD+BCP (10 mg/kg), PD+BCP (20 mg/kg), PD+SD (20 mg/kg) and PD+BCP (20 mg/kg)+SD (20 mg/kg). Oral administration of 20 mg/kg body weight of PD for the first 7 days was done while treatment with BCP and SD were performed between 8 and 14 days prior to euthanasia. The sexual performance study revealed that PD caused erectile dysfuction. Elevated activities of phosphodiesterase-5' (PDE-5'), arginase, adenosine deaminase (ADA), acetylcholinesterase (AChE) and angiotensin-I converting enzyme (ACE) as well as lipid peroxidation level were observed in PD-induced rats when compared to the NC group. However, treatment with sildenafil and/ or β-Caryophyllene significantly reduced the activities of AChE, PDE-5', arginase, ADA, and ACE in penile tissues of PD-induced rats. In addition, co-administration of β-caryophyllene and sildenafil citrate showed better modulatory effects. Thus, β-caryophyllene could represent a potential nutraceutical in the management of erectile dysfunction.
Keywords
${\beta}$-caryophyllene; Sildenafil citrate; Paroxetine; Enzymes; Erectile dysfunction;
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