Browse > Article
http://dx.doi.org/10.5487/TR.2018.34.2.097

Oral Wound Healing Effects of Acai Berry Water Extracts in Rat Oral Mucosa  

Kang, Mi Hyun (Major in Public Health, Faculty of Food and Health Sciences, Keimyung University)
Kim, Bae-Hwan (Major in Public Health, Faculty of Food and Health Sciences, Keimyung University)
Publication Information
Toxicological Research / v.34, no.2, 2018 , pp. 97-102 More about this Journal
Abstract
The objective of this study was to determine the oral wound healing effects of acai berry water extracts (ABWE) in rat oral mucosa. To estimate the anti-oxidative effects of ABWE, the contents of phenolic compounds, and DPPH (1,1-diphenyl-2-picryl hydrazyl) and ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) abilities were evaluated. Wound healing effects of ABWE were tested following 6-day exposure after induction of wound by applying 50% acetic acid to oral mucosa of Sprague-Dawley rats. Macroscopic and histopathological analyses were performed to determine wound healing effects of ABWE. Sodium fusidate (20 mg/g) was used as positive control. ABWE showed significantly high antioxidant effects in all assays, although its potency was weaker than the positive control. From day 3 after treatment, wound healing effects of ABWE were observed in oral mucosa. These wound healing effects were also consistent with histopathological evaluation results. Taken together, these results indicate that ABWE might have potential as an oral wound healing agent in the future.
Keywords
Oral wound healing; Acai berry water extracts; Anti-oxidant; Rat oral mucosa;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Sciubba, J.J., Waterhouse, J.P. and Meyer, J. (1978) A fine structural comparison of the healing of incisional wounds of mucosa and skin. J. Oral Pathol., 7, 214-227.   DOI
2 Kirsner, R.S. and Eaglstein, W.H. (1993) The wound healing process. Dermatol. Clin., 11, 629-640.
3 Park, J.E. and Barbul, A. (2004) Understanding the role of immune regulation in wound healing. Am. J. Surg., 187, 11S-16S.   DOI
4 Diegelmann, R.F. and Evans, M.C. (2004) Wound healing: an overview of acute, fibrotic and delayed healing. Front. Biosci., 9, 283-289.   DOI
5 Cleland, W.P., Jr. (2001) Opportunities and obstacles in veterinary dental drug delivery. Adv. Drug Deliv. Rev., 50, 261-275.   DOI
6 Han, D.O., Lee, H.J. and Hahm, D.H. (2009) Wound-healing activity of Astragali radix in rats. Methods Find. Exp. Clin. Pharmacol., 31, 95-100.   DOI
7 Schauss, A.G., Wu, X., Prior, R.L., Ou, B., Patel, D., Huang, D. and Kababick, J.P. (2006) Phytochemical and nutrient composition of the freeze-dried amazonian palm berry, Euterpe oleraceae mart. (acai). J. Agric. Food Chem., 54, 8598-8603.   DOI
8 Kim, S.Y., Park, K.H., Moon, H.D., Jung, S.H., Lee, S.E. and Kim, B.H. (2017) Anti-inflammatory effects of acai berry ethanol extracts. J. Kor. Soc. Cosm., 23, 669-676.
9 Kang, M.H., Choi, S.H. and Kim, B.H. (2017) Skin wound healing effects and action mechanism of acai berry water extracts. Toxicol. Res., 33, 149-156.   DOI
10 Folin, O. and Denis, W. (1912) On phosphotungstic-phosphomolybdic compounds as color regents. J. Biol. Chem., 12, 239-243.
11 Blois, M.S. (1958) Antioxidant determinations by the use of a stable free radical. Nature, 181, 1199-1200.   DOI
12 Buranasukhon, W., Athikomkulchai, S., Tadtong, S. and Chittasupho, C. (2017) Wound healing activity of Pluchea indica leaf extract in oral mucosal cell line and oral spray formulation containing nanoparticles of the extract. Pharm Biol., 55, 1767-1774.   DOI
13 Kim, J.Y., Hong, J.E., Jung, H.K., Jeong, Y.S. and Cho, K.H. (2012) Grape skin and loquat leaf extracts and acai puree have potent anti-atherosclerotic and anti-diabetic activity in vitro and in vivo in hypercholesterolemic zebrafish. Int. J. Mol. Med., 30, 606-614.   DOI
14 Lee, N.Y., Chung, K.S., Jin, J.S., Lee, Y.C. and An, H.J. (2017) The inhibitory effect of nodakenin on mast-cell-mediated allergic inflammation via downregulation of NF-${\kappa}B$ and caspase-1 activation. J. Cell Biochem., 118, 3993-4001.   DOI
15 Clark, R.A. (1993) Regulation of fibroplasia in cutaneous wound repair. Am. J. Med. Sci., 306, 42-48.   DOI
16 Fujisawa, K., Miyamoto, Y. and Nagayama, M. (2003) Basic fibroblast growth factor and epidermal growth factor reverse impaired ulcer healing of the rabbit oral mucosa. J. Oral Pathol. Med., 32, 358-366.   DOI
17 Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M. and Rice-Evans, C. (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic. Biol. Med., 26, 1231-1237.   DOI
18 Marklund, S. and Marklund, G. (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem., 47, 469-474.   DOI
19 Muralidhar, A., Babu, K.S., Sankar, T.R., Reddanna, P. and Latha, J. (2011) Evaluation of wound healing properties of bioactive fractions from the extract of Butea monosperma (lam) stem bark. Int. J. Phytomed., 3, 41-49.
20 Velnar, T., Bailey, T. and Smrkolj, V. (2009) The wound healing process: an overview of the cellular and molecular mechanisms. J. Int. Med. Res., 37, 1528-1542.   DOI
21 Shim, K.M., Kim, S.E., Choi, J.Y., Park, J.C., Jeong, S.J., Lee, J.Y., Bae, C.S., Park, D.H., Kim, D.M. and Jeong, M.J. (2006) Effects of Aucuba japonica extract on oral wound healing. J. Vet. Clin., 23, 55-60.
22 Nayak, B.S., Sandiford, S. and Maxwell, A. (2009) Evaluation of the wound healing activity of ethanolic extract of Morinda citrifolia L. leaf. Evid. Based Complement. Alternat. Med., 6, 351-356.   DOI
23 Duarte, C.M., Quirino, M.R., Patrocinio, M.C. and Anbinder, A.L. (2011) Effects of Chamomilla recutita (L.) on oral wound healing in rats. Med. Oral Patol. Oral Cir. Bucal, 16, 716-721.
24 Jung, H.K., Kim, K.S. and Jeong, Y.S. (2014) Wound healing effects of Lespedeza cuneate extract. J. Korea Soc. Food Sci. Nutr., 43, 374-380.   DOI
25 Sen, C.K., Khanna, S., Gordillo, G., Bagchi, D., Bagchi, M. and Roy, S. (2002) Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann. N. Y. Acad. Sci., 957, 239-249.   DOI
26 Kang, J., Li, Z., Wu, T., Jensen, G.S., Schauss, A.G. and Wu, X. (2010) Anti-oxidant capacities of flavonoid compounds isolated from acai pulp (Euterpe oleracea Mart.). Food Chem., 122, 610-617.   DOI