Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway |
Na, Ann-Yae
(BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University)
Yang, Eun-Ju (BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University) Jeon, Ju Mi (College of Pharmacy, Chosun University) Ki, Sung Hwan (BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University) Song, Kyung-Sik (BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University) Lee, Sangkyu (BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University) |
1 | O'Shea, R.S., Dasarathy, S. and McCullough, A.J. (2010) Alcoholic liver disease. Am. J. Gastroenterol., 105, 14-32. DOI |
2 | Watanabe, Y., Nagai, Y., Honda, H., Okamoto, N., Yamamoto, S., Hamashima, T., Ishii, Y., Tanaka, M., Suganami, T., Sasahara, M., Miyake, K. and Takatsu, K. (2016) Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice. Sci. Rep., 6, 23097. DOI |
3 | Gao, B. and Bataller, R. (2011) Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology, 141, 1572-1585. DOI |
4 | Nagy, L.E., Ding, W.X., Cresci, G., Saikia, P. and Shah, V.H. (2016) Linking pathogenic mechanisms of alcoholic liver disease with clinical phenotypes. Gastroenterology, 150, 1756-1768. DOI |
5 | Lieber, C.S., Leo, M.A., Wang, X. and Decarli, L.M. (2008) Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1alpha in rats. Biochem. Biophys. Res. Commun., 370, 44-48. DOI |
6 | Lu, Y. and Cederbaum, A.I. (2008) CYP2E1 and oxidative liver injury by alcohol. Free. Radic. Biol. Med., 44, 723-738. |
7 | Purushotham, A., Xu, Q. and Li, X. (2012) Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding. FASEB J., 26, 656-667. DOI |
8 | Shen, Z., Ajmo, J.M., Rogers, C.Q., Liang, X., Le, L., Murr, M.M., Peng, Y. and You, M. (2009) Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines. Am. J. Physiol. Gastrointest. Liver Physiol., 296, G1047-G1053. DOI |
9 | Ajmo, J.M., Liang, X., Rogers, C.Q., Pennock, B. and You, M. (2008) Resveratrol alleviates alcoholic fatty liver in mice. Am. J. Physiol. Gastrointest. Liver Physiol., 295, G833-G842. DOI |
10 | Shen, Z., Liang, X., Rogers, C.Q., Rideout, D. and You, M. (2010) Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. Am. J. Physiol. Gastrointest. Liver Physiol., 298, G364-G374. DOI |
11 | Everitt, H., Hu, M., Ajmo, J.M., Rogers, C.Q., Liang, X., Zhang, R., Yin, H., Choi, A., Bennett, E.S. and You, M. (2013) Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice. Am. J. Physiol. Gastrointest. Liver Physiol., 304, G38-G47. DOI |
12 | Lan, F., Cacicedo, J.M., Ruderman, N. and Ido, Y. (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J. Biol. Chem., 283, 27628-27635. DOI |
13 | Lin, H., Liu, J. and Zhang, Y. (2011) Developments in cancer prevention and treatment using traditional Chinese medicine. Front. Med., 5, 127-133. DOI |
14 | Cao, Y., Wang, Y., Ji, C. and Ye, J. (2004) Determination of liquiritigenin and isoliquiritigenin in Glycyrrhiza uralensis and its medicinal preparations by capillary electrophoresis with electrochemical detection. J. Chromatogr. A, 9, 1-2. |
15 | Ii, T., Satomi, Y., Katoh, D., Shimada, J., Baba, M., Okuyama, T., Nishino, H. and Kitamura, N. (2004) Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin. Cancer Lett., 207, 27-35. DOI |
16 | Haraguchi, H., Ishikawa, H., Mizutani, K., Tamura, Y. and Kinoshita, T. (1998) Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata. Bioorg. Med. Chem., 6, 339-347. DOI |
17 | Tawata, M., Aida, K., Noguchi, T., Ozaki, Y., Kume, S., Sasaki, H., Chin, M. and Onaya, T. (1992) Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice. Eur. J. Pharmacol., 212, 87-92. DOI |
18 | Yu, S.M. and Kuo, S.C. (1995) Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta. Br. J. Pharmacol., 114, 1587-1594. DOI |
19 | Tamir, S., Eizenberg, M., Somjen, D., Izrael, S. and Vaya, J. (2001) Estrogen-like activity of glabrene and other constituents isolated from licorice root. J. Steroid. Biochem. Mol. Biol., 78, 291-298. DOI |
20 | Lee, Y.K., Chin, Y.W., Bae, J.K., Seo, J.S. and Choi, Y.H. (2013) Pharmacokinetics of isoliquiritigenin and its metabolites in rats: low bioavailability is primarily due to the hepatic and intestinal metabolism. Planta. Med., 79, 1656-1665. |
21 | Wang, Z., Wang, N., Liu, P., Chen, Q., Situ, H., Xie, T., Zhang, J., Peng, C., Lin, Y. and Chen, J. (2014) MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin. Oncotarget, 5, 7013-7026. |
22 | Lee, H.K., Yang, E.J., Kim, J.Y., Song, K.S. and Seong, Y.H. (2012) Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Abeta(25-35)-induced neurotoxicity in cultured rat cortical neurons. Arch. Pharm. Res., 35, 897-904. DOI |
23 | Ruderman, N.B., Xu, X.J., Nelson, L., Cacicedo, J.M., Saha, A.K., Lan, F. and Ido, Y. (2010) AMPK and SIRT1: a long-standing partnership? Am. J. Physiol. Endocrinol. Metab., 298, E751-E760. |
24 | Kim, S.J., Ki, S.H. and Lee, S. (2015) Protective effects of korean red ginseng against alcohol-induced hepatosteatosis. J. Life Sci., 25, 317-322. DOI |
25 | Luo, H., Cao, R., Wang, L. and Zhu, L. (2016) Protective effect of Cistanchis A on ethanol-induced damage in primary cultured mouse hepatocytes. Biomed. Pharmacother., 83, 1071-1079. |
26 | Kim, Y.G., Ramachandran, S., Kim, D.C., Hong, Y.B., Kim, E.H., Kwon, S.H., Shin, S.J., Cha, S.D., Bae, I. and Cho, C.H. (2010) Isoliquiritigenin inhibited cell proliferation and triggered apoptosis in human endometrial cancer cell Line. J. Womens Med., 3, 89-95. DOI |
27 |
Dagon, Y., Mantzoros, C.S. and Kim, Y.B. (2016) AMPK |
28 | Banerjee, J., Bruckbauer, A. and Zemel, M.B. (2016) Activation of the AMPK/Sirt1 pathway by a leucine-metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans. Metabolism, 65, 1679-1691. DOI |
29 | Hou, X., Xu, S., Maitland-Toolan, K.A., Sato, K., Jiang, B., Ido, Y., Lan, F., Walsh, K., Wierzbicki, M., Verbeuren, T.J., Cohen, R.A. and Zang, M. (2008) SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J. Biol. Chem., 283, 20015-20026. DOI |
30 | Kalaany, N.Y. and Mangelsdorf, D.J. (2006) LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu. Rev. Physiol., 68, 159-191. DOI |
31 | Yin, H.Q., Kim, M., Kim, J.H., Kong, G., Kang, K.S., Kim, H.L., Yoon, B.I., Lee, M.O. and Lee, B.H. (2007) Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice. Toxicol. Appl. Pharmacol., 223, 225-233. DOI |
32 | Han, J.Y., Lee, S., Yang, J.H., Kim, S., Sim, J., Kim, M.G., Jeong, T.C., Ku, S.K., Cho, I.J. and Ki, S.H. (2015) Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation. J. Ginseng Res., 39, 105-115. DOI |
33 | Donohue, T.M., Jr. (2007) Alcohol-induced steatosis in liver cells. World J. Gastroenterol., 13, 4974-4978. DOI |
34 | Canto, C. and Auwerx, J. (2009) PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr. Opin. Lipidol., 20, 98-105. DOI |
35 | Shen, Z., Liang, X., Rogers, C.Q., Rideout, D. and You, M. (2010) Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. Am. J. Physiol. Gastrointest. Liver Physiol., 298, G364-G374. DOI |
36 | Liu, J. (2014) Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver. World J. Gastroenterol., 20, 14672-14685. DOI |
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